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Small molecules for dissecting endomembrane trafficking: a cross-systems view

Kiril Mishev, Wim Dejonghe and Eugenia Russinova UGent (2013) CHEMISTRY & BIOLOGY. 20(4). p.475-486
abstract
Endomembrane trafficking has a key role for ensuring homeostasis, growth and development, hormonal signaling, and adaptation of eukaryotes to the constantly changing environmental conditions. The complex organization of the endomembrane system implies the need for searching novel tools to specifically probe the regulatory components and dissect the tightly interconnected vesicle transport pathways. Here, we review the large-scale chemical genetic screens, which led to the identification of small molecules with an impact on various parts of the vesicle trafficking network. We discuss the similarities and differences in the organization of the endomembrane systems in yeasts, mammals, and plants based on studies of small molecules and their effects on trafficking hubs, routes, and conserved protein targets.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
SECRETORY PATHWAY, ACTIN CYTOSKELETON, TRANSFERRIN RECEPTOR, MEMBRANE TRAFFICKING, BREFELDIN-A, PLANT-CELLS, CHEMICAL GENETICS, HIGH-THROUGHPUT SCREEN, CLATHRIN-MEDIATED ENDOCYTOSIS, GOLGI NETWORK/EARLY ENDOSOME
journal title
CHEMISTRY & BIOLOGY
Chem. Biol.
volume
20
issue
4
pages
475 - 486
Web of Science type
Review
Web of Science id
000318201700006
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
6.586 (2013)
JCR rank
34/291 (2013)
JCR quartile
1 (2013)
ISSN
1074-5521
DOI
10.1016/j.chembiol.2013.03.009
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3233415
handle
http://hdl.handle.net/1854/LU-3233415
date created
2013-06-03 14:00:01
date last changed
2016-12-19 15:45:43
@article{3233415,
  abstract     = {Endomembrane trafficking has a key role for ensuring homeostasis, growth and development, hormonal signaling, and adaptation of eukaryotes to the constantly changing environmental conditions. The complex organization of the endomembrane system implies the need for searching novel tools to specifically probe the regulatory components and dissect the tightly interconnected vesicle transport pathways. Here, we review the large-scale chemical genetic screens, which led to the identification of small molecules with an impact on various parts of the vesicle trafficking network. We discuss the similarities and differences in the organization of the endomembrane systems in yeasts, mammals, and plants based on studies of small molecules and their effects on trafficking hubs, routes, and conserved protein targets.},
  author       = {Mishev, Kiril and Dejonghe, Wim and Russinova, Eugenia},
  issn         = {1074-5521},
  journal      = {CHEMISTRY \& BIOLOGY},
  keyword      = {SECRETORY PATHWAY,ACTIN CYTOSKELETON,TRANSFERRIN RECEPTOR,MEMBRANE TRAFFICKING,BREFELDIN-A,PLANT-CELLS,CHEMICAL GENETICS,HIGH-THROUGHPUT SCREEN,CLATHRIN-MEDIATED ENDOCYTOSIS,GOLGI NETWORK/EARLY ENDOSOME},
  language     = {eng},
  number       = {4},
  pages        = {475--486},
  title        = {Small molecules for dissecting endomembrane trafficking: a cross-systems view},
  url          = {http://dx.doi.org/10.1016/j.chembiol.2013.03.009},
  volume       = {20},
  year         = {2013},
}

Chicago
Mishev, Kiril, Wim Dejonghe, and Eugenia Russinova. 2013. “Small Molecules for Dissecting Endomembrane Trafficking: a Cross-systems View.” Chemistry & Biology 20 (4): 475–486.
APA
Mishev, K., Dejonghe, W., & Russinova, E. (2013). Small molecules for dissecting endomembrane trafficking: a cross-systems view. CHEMISTRY & BIOLOGY, 20(4), 475–486.
Vancouver
1.
Mishev K, Dejonghe W, Russinova E. Small molecules for dissecting endomembrane trafficking: a cross-systems view. CHEMISTRY & BIOLOGY. 2013;20(4):475–86.
MLA
Mishev, Kiril, Wim Dejonghe, and Eugenia Russinova. “Small Molecules for Dissecting Endomembrane Trafficking: a Cross-systems View.” CHEMISTRY & BIOLOGY 20.4 (2013): 475–486. Print.