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Small molecules for dissecting endomembrane trafficking: a cross-systems view

Kiril Mishev (UGent) , Wim Dejonghe (UGent) and Eugenia Russinova (UGent)
(2013) CHEMISTRY & BIOLOGY. 20(4). p.475-486
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Abstract
Endomembrane trafficking has a key role for ensuring homeostasis, growth and development, hormonal signaling, and adaptation of eukaryotes to the constantly changing environmental conditions. The complex organization of the endomembrane system implies the need for searching novel tools to specifically probe the regulatory components and dissect the tightly interconnected vesicle transport pathways. Here, we review the large-scale chemical genetic screens, which led to the identification of small molecules with an impact on various parts of the vesicle trafficking network. We discuss the similarities and differences in the organization of the endomembrane systems in yeasts, mammals, and plants based on studies of small molecules and their effects on trafficking hubs, routes, and conserved protein targets.
Keywords
SECRETORY PATHWAY, ACTIN CYTOSKELETON, TRANSFERRIN RECEPTOR, MEMBRANE TRAFFICKING, BREFELDIN-A, PLANT-CELLS, CHEMICAL GENETICS, HIGH-THROUGHPUT SCREEN, CLATHRIN-MEDIATED ENDOCYTOSIS, GOLGI NETWORK/EARLY ENDOSOME

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Citation

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Chicago
Mishev, Kiril, Wim Dejonghe, and Eugenia Russinova. 2013. “Small Molecules for Dissecting Endomembrane Trafficking: a Cross-systems View.” Chemistry & Biology 20 (4): 475–486.
APA
Mishev, K., Dejonghe, W., & Russinova, E. (2013). Small molecules for dissecting endomembrane trafficking: a cross-systems view. CHEMISTRY & BIOLOGY, 20(4), 475–486.
Vancouver
1.
Mishev K, Dejonghe W, Russinova E. Small molecules for dissecting endomembrane trafficking: a cross-systems view. CHEMISTRY & BIOLOGY. 2013;20(4):475–86.
MLA
Mishev, Kiril, Wim Dejonghe, and Eugenia Russinova. “Small Molecules for Dissecting Endomembrane Trafficking: a Cross-systems View.” CHEMISTRY & BIOLOGY 20.4 (2013): 475–486. Print.
@article{3233415,
  abstract     = {Endomembrane trafficking has a key role for ensuring homeostasis, growth and development, hormonal signaling, and adaptation of eukaryotes to the constantly changing environmental conditions. The complex organization of the endomembrane system implies the need for searching novel tools to specifically probe the regulatory components and dissect the tightly interconnected vesicle transport pathways. Here, we review the large-scale chemical genetic screens, which led to the identification of small molecules with an impact on various parts of the vesicle trafficking network. We discuss the similarities and differences in the organization of the endomembrane systems in yeasts, mammals, and plants based on studies of small molecules and their effects on trafficking hubs, routes, and conserved protein targets.},
  author       = {Mishev, Kiril and Dejonghe, Wim and Russinova, Eugenia},
  issn         = {1074-5521},
  journal      = {CHEMISTRY \& BIOLOGY},
  keyword      = {SECRETORY PATHWAY,ACTIN CYTOSKELETON,TRANSFERRIN RECEPTOR,MEMBRANE TRAFFICKING,BREFELDIN-A,PLANT-CELLS,CHEMICAL GENETICS,HIGH-THROUGHPUT SCREEN,CLATHRIN-MEDIATED ENDOCYTOSIS,GOLGI NETWORK/EARLY ENDOSOME},
  language     = {eng},
  number       = {4},
  pages        = {475--486},
  title        = {Small molecules for dissecting endomembrane trafficking: a cross-systems view},
  url          = {http://dx.doi.org/10.1016/j.chembiol.2013.03.009},
  volume       = {20},
  year         = {2013},
}

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