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Intensity-dependent modulatory effects of vagus nerve stimulation on cortical excitability

Lies Mollet, Annelies Grimonprez, Robrecht Raedt UGent, Jean Delbeke, RIEM EL TAHRY, Veerle De Herdt UGent, Alfred Meurs UGent, Wytse Wadman, Paul Boon UGent and Kristl Vonck UGent (2013) ACTA NEUROLOGICA SCANDINAVICA. 128(6). p.391-396
abstract
Vagus nerve stimulation (VNS) is an effective treatment for refractory epilepsy. It remains unknown whether VNS efficacy is dependent on output current intensity. The present study investigated the effect of various VNS output current intensities on cortical excitability in the motor cortex stimulation rat model. The hypothesis was that output current intensities in the lower range are sufficient to significantly affect cortical excitability. VNS at four output current intensities (0 mA, 0.25 mA, 0.5 mA and 1 mA) was randomly administered in rats (n = 15) on four consecutive days. Per output current intensity, the animals underwent five-one-hour periods: (i) baseline, (ii) VNS1, (iii) wash-out1, (iv) VNS2 and (v) wash-out2. After each one-hour period, the motor seizure threshold (MST) was measured and compared to baseline (i.e. ∆MSTbaseline , ∆MSTVNS 1 , ∆MSTwash-out1 , ∆MSTVNS 2 and ∆MSTwash-out2 ). Finally, the mean ∆MSTbaseline , mean ∆MSTwash-out1 , mean ∆MSTwash-out2 and mean ∆MSTVNS per VNS output current intensity were calculated. No differences were found between the mean ∆MSTbaseline , mean ∆MSTwash-out1 and mean ∆MSTwash-out2 within each VNS output current intensity. The mean ∆MSTVNS at 0 mA, 0.25 mA, 0.5 mA and 1 mA was 15.3 ± 14.6 μA, 101.8 ± 23.5 μA, 108.1 ± 24.4 μA and 85.7 ± 18.1 μA respectively. The mean ∆MSTVNS at 0.25 mA, 0.5 mA and 1 mA were significantly larger compared to the mean ∆MSTVNS at 0 mA (P = 0.002 for 0.25 mA; P = 0.001 for 0.5 mA; P = 0.011 for 1 mA). This study confirms efficacy of VNS in the motor cortex stimulation rat model and indicates that, of the output current intensities tested, 0.25 mA is sufficient to decrease cortical excitability and higher output current intensities may not be required.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
stimulation parameters, vagus nerve stimulation, motor cortex stimulation rat model, epilepsy, REFRACTORY EPILEPSY, SEIZURES, MODEL, RAT, THRESHOLD, MECHANISM, EFFICACY, THERAPY, BRAIN, SPECT
journal title
ACTA NEUROLOGICA SCANDINAVICA
Acta Neurol. Scand.
volume
128
issue
6
pages
391 - 396
Web of Science type
Article
Web of Science id
000326068600007
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.437 (2013)
JCR rank
87/194 (2013)
JCR quartile
2 (2013)
ISSN
0001-6314
DOI
10.1111/ane.12135
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3232189
handle
http://hdl.handle.net/1854/LU-3232189
date created
2013-06-03 08:28:54
date last changed
2016-12-19 15:47:19
@article{3232189,
  abstract     = {Vagus nerve stimulation (VNS) is an effective treatment for refractory epilepsy. It remains unknown whether VNS efficacy is dependent on output current intensity. The present study investigated the effect of various VNS output current intensities on cortical excitability in the motor cortex stimulation rat model. The hypothesis was that output current intensities in the lower range are sufficient to significantly affect cortical excitability.
VNS at four output current intensities (0 mA, 0.25 mA, 0.5 mA and 1 mA) was randomly administered in rats (n = 15) on four consecutive days. Per output current intensity, the animals underwent five-one-hour periods: (i) baseline, (ii) VNS1, (iii) wash-out1, (iv) VNS2 and (v) wash-out2. After each one-hour period, the motor seizure threshold (MST) was measured and compared to baseline (i.e. \unmatched{2206}MSTbaseline , \unmatched{2206}MSTVNS 1 , \unmatched{2206}MSTwash-out1 , \unmatched{2206}MSTVNS 2 and \unmatched{2206}MSTwash-out2 ). Finally, the mean \unmatched{2206}MSTbaseline , mean \unmatched{2206}MSTwash-out1 , mean \unmatched{2206}MSTwash-out2 and mean \unmatched{2206}MSTVNS per VNS output current intensity were calculated.
No differences were found between the mean \unmatched{2206}MSTbaseline , mean \unmatched{2206}MSTwash-out1 and mean \unmatched{2206}MSTwash-out2 within each VNS output current intensity. The mean \unmatched{2206}MSTVNS at 0 mA, 0.25 mA, 0.5 mA and 1 mA was 15.3 {\textpm} 14.6 \ensuremath{\mu}A, 101.8 {\textpm} 23.5 \ensuremath{\mu}A, 108.1 {\textpm} 24.4 \ensuremath{\mu}A and 85.7 {\textpm} 18.1 \ensuremath{\mu}A respectively. The mean \unmatched{2206}MSTVNS at 0.25 mA, 0.5 mA and 1 mA were significantly larger compared to the mean \unmatched{2206}MSTVNS at 0 mA (P = 0.002 for 0.25 mA; P = 0.001 for 0.5 mA; P = 0.011 for 1 mA).
This study confirms efficacy of VNS in the motor cortex stimulation rat model and indicates that, of the output current intensities tested, 0.25 mA is sufficient to decrease cortical excitability and higher output current intensities may not be required.},
  author       = {Mollet, Lies and Grimonprez, Annelies and Raedt, Robrecht and Delbeke, Jean and EL TAHRY, RIEM and De Herdt, Veerle and Meurs, Alfred and Wadman, Wytse and Boon, Paul and Vonck, Kristl},
  issn         = {0001-6314},
  journal      = {ACTA NEUROLOGICA SCANDINAVICA},
  keyword      = {stimulation parameters,vagus nerve stimulation,motor cortex stimulation rat model,epilepsy,REFRACTORY EPILEPSY,SEIZURES,MODEL,RAT,THRESHOLD,MECHANISM,EFFICACY,THERAPY,BRAIN,SPECT},
  language     = {eng},
  number       = {6},
  pages        = {391--396},
  title        = {Intensity-dependent modulatory effects of vagus nerve stimulation on cortical excitability},
  url          = {http://dx.doi.org/10.1111/ane.12135},
  volume       = {128},
  year         = {2013},
}

Chicago
Mollet, Lies, Annelies Grimonprez, Robrecht Raedt, Jean Delbeke, RIEM EL TAHRY, Veerle De Herdt, Alfred Meurs, Wytse Wadman, Paul Boon, and Kristl Vonck. 2013. “Intensity-dependent Modulatory Effects of Vagus Nerve Stimulation on Cortical Excitability.” Acta Neurologica Scandinavica 128 (6): 391–396.
APA
Mollet, L., Grimonprez, A., Raedt, R., Delbeke, J., EL TAHRY, R., De Herdt, V., Meurs, A., et al. (2013). Intensity-dependent modulatory effects of vagus nerve stimulation on cortical excitability. ACTA NEUROLOGICA SCANDINAVICA, 128(6), 391–396.
Vancouver
1.
Mollet L, Grimonprez A, Raedt R, Delbeke J, EL TAHRY R, De Herdt V, et al. Intensity-dependent modulatory effects of vagus nerve stimulation on cortical excitability. ACTA NEUROLOGICA SCANDINAVICA. 2013;128(6):391–6.
MLA
Mollet, Lies, Annelies Grimonprez, Robrecht Raedt, et al. “Intensity-dependent Modulatory Effects of Vagus Nerve Stimulation on Cortical Excitability.” ACTA NEUROLOGICA SCANDINAVICA 128.6 (2013): 391–396. Print.