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Gradient stationary phase optimized selectivity liquid chromatography with conventional columns

Kai Chen (UGent) , Frederic Lynen (UGent) , Roman Szucs (UGent) , Melissa Hanna-Brown and Patrick Sandra (UGent)
(2013) ANALYST. 138(10). p.2914-2923
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Abstract
Stationary phase optimized selectivity liquid chromatography (SOSLC) is a promising technique to optimize the selectivity of a given separation. By combination of different stationary phases, SOSLC offers excellent possibilities for method development under both isocratic and gradient conditions. The so far available commercial SOSLC protocol utilizes dedicated column cartridges and corresponding cartridge holders to build up the combined column of different stationary phases. The present work is aimed at developing and extending the gradient SOSLC approach towards coupling conventional columns. Generic tubing was used to connect short commercially available LC columns. Fast and base-line separation of a mixture of 12 compounds containing phenones, benzoic acids and hydroxybenzoates under both isocratic and linear gradient conditions was selected to demonstrate the potential of SOSLC. The influence of the connecting tubing on the deviation of predictions is also discussed.
Keywords
gradient SOSLC, HPLC

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Please use this url to cite or link to this publication:

MLA
Chen, Kai, Frederic Lynen, Roman Szucs, et al. “Gradient Stationary Phase Optimized Selectivity Liquid Chromatography with Conventional Columns.” ANALYST 138.10 (2013): 2914–2923. Print.
APA
Chen, Kai, Lynen, F., Szucs, R., Hanna-Brown, M., & Sandra, P. (2013). Gradient stationary phase optimized selectivity liquid chromatography with conventional columns. ANALYST, 138(10), 2914–2923.
Chicago author-date
Chen, Kai, Frederic Lynen, Roman Szucs, Melissa Hanna-Brown, and Patrick Sandra. 2013. “Gradient Stationary Phase Optimized Selectivity Liquid Chromatography with Conventional Columns.” Analyst 138 (10): 2914–2923.
Chicago author-date (all authors)
Chen, Kai, Frederic Lynen, Roman Szucs, Melissa Hanna-Brown, and Patrick Sandra. 2013. “Gradient Stationary Phase Optimized Selectivity Liquid Chromatography with Conventional Columns.” Analyst 138 (10): 2914–2923.
Vancouver
1.
Chen K, Lynen F, Szucs R, Hanna-Brown M, Sandra P. Gradient stationary phase optimized selectivity liquid chromatography with conventional columns. ANALYST. 2013;138(10):2914–23.
IEEE
[1]
K. Chen, F. Lynen, R. Szucs, M. Hanna-Brown, and P. Sandra, “Gradient stationary phase optimized selectivity liquid chromatography with conventional columns,” ANALYST, vol. 138, no. 10, pp. 2914–2923, 2013.
@article{3231823,
  abstract     = {Stationary phase optimized selectivity liquid chromatography (SOSLC) is a promising technique to optimize the selectivity of a given separation. By combination of different stationary phases, SOSLC offers excellent possibilities for method development under both isocratic and gradient conditions. The so far available commercial SOSLC protocol utilizes dedicated column cartridges and corresponding cartridge holders to build up the combined column of different stationary phases. The present work is aimed at developing and extending the gradient SOSLC approach towards coupling conventional columns. Generic tubing was used to connect short commercially available LC columns. Fast and base-line separation of a mixture of 12 compounds containing phenones, benzoic acids and hydroxybenzoates under both isocratic and linear gradient conditions was selected to demonstrate the potential of SOSLC. The influence of the connecting tubing on the deviation of predictions is also discussed.},
  author       = {Chen, Kai and Lynen, Frederic and Szucs, Roman and Hanna-Brown, Melissa and Sandra, Patrick},
  issn         = {0003-2654},
  journal      = {ANALYST},
  keywords     = {gradient SOSLC,HPLC},
  language     = {eng},
  number       = {10},
  pages        = {2914--2923},
  title        = {Gradient stationary phase optimized selectivity liquid chromatography with conventional columns},
  url          = {http://dx.doi.org/10.1039/c3an36797e},
  volume       = {138},
  year         = {2013},
}

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