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Neural correlates of motor dysfunction in children with traumatic brain injury: exploration of compensatory recruitment patterns

Karen Caeyenberghs, N Wenderoth, BC Smits-Engelsman, S Sunaert and SP Swinnen (2009) BRAIN. 132(3). p.684-694
abstract
Traumatic brain injury (TBI) is a common form of disability in children. Persistent deficits in motor control have been documented following TBI but there has been less emphasis on changes in functional cerebral activity. In the present study, children with moderate to severe TBI (n 9) and controls (n 17) were scanned while performing cyclical movements with their dominant and non-dominant hand and foot according to the easy isodirectional (same direction) and more difficult non-isodirectional (opposite direction) mode. Even though the children with TBI were shown to be less successful on various items of a clinical motor test battery than the control group, performance on the coordination task during scanning was similar between groups, allowing a meaningful interpretation of their brain activation differences. fMRI analysis revealed that the TBI children showed enhanced activity in medial and anterior parietal areas as well as posterior cerebellum as compared with the control group. Brain activation generally increased during the non-isodirectional as compared with the isodirectional mode and additional regions were involved, consistent with their differential degree of difficulty. However, this effect did not interact with group. Overall, the findings indicate that motor impairment in TBI children is associated with changes in functional cerebral activity, i.e. they exhibit compensatory activation reflecting increased recruitment of neural resources for attentional deployment and somatosensory processing.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
INTERLIMB COORDINATION, FUNCTIONAL REORGANIZATION, COMMON STEREOTACTIC SPACE, PURKINJE-CELL VULNERABILITY, POSITRON-EMISSION-TOMOGRAPHY, children, interlimb coordination, motor control, Traumatic brain injury, fMRI, BIMANUAL COORDINATION, RHYTHMIC COORDINATION, AUTOMATIC MOVEMENTS, PARKINSONS-DISEASE, PHASE-TRANSITIONS
journal title
BRAIN
Brain
volume
132
issue
3
pages
684 - 694
Web of Science type
Article
Web of Science id
000264889000013
JCR category
CLINICAL NEUROLOGY
JCR impact factor
9.49 (2009)
JCR rank
2/165 (2009)
JCR quartile
1 (2009)
ISSN
0006-8950
DOI
10.1093/brain/awn344
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3231510
handle
http://hdl.handle.net/1854/LU-3231510
date created
2013-05-31 15:51:17
date last changed
2016-12-19 15:45:44
@article{3231510,
  abstract     = {Traumatic brain injury (TBI) is a common form of disability in children. Persistent deficits in motor control have been documented following TBI but there has been less emphasis on changes in functional cerebral activity. In the present study, children with moderate to severe TBI (n 9) and controls (n 17) were scanned while performing cyclical movements with their dominant and non-dominant hand and foot according to the easy isodirectional (same direction) and more difficult non-isodirectional (opposite direction) mode. Even though the children with TBI were shown to be less successful on various items of a clinical motor test battery than the control group, performance on the coordination task during scanning was similar between groups, allowing a meaningful interpretation of their brain activation differences. fMRI analysis revealed that the TBI children showed enhanced activity in medial and anterior parietal areas as well as posterior cerebellum as compared with the control group. Brain activation generally increased during the non-isodirectional as compared with the isodirectional mode and additional regions were involved, consistent with their differential degree of difficulty. However, this effect did not interact with group. Overall, the findings indicate that motor impairment in TBI children is associated with changes in functional cerebral activity, i.e. they exhibit compensatory activation reflecting increased recruitment of neural resources for attentional deployment and somatosensory processing.},
  author       = {Caeyenberghs, Karen and Wenderoth, N and Smits-Engelsman, BC and Sunaert, S and Swinnen, SP},
  issn         = {0006-8950},
  journal      = {BRAIN},
  keyword      = {INTERLIMB COORDINATION,FUNCTIONAL REORGANIZATION,COMMON STEREOTACTIC SPACE,PURKINJE-CELL VULNERABILITY,POSITRON-EMISSION-TOMOGRAPHY,children,interlimb coordination,motor control,Traumatic brain injury,fMRI,BIMANUAL COORDINATION,RHYTHMIC COORDINATION,AUTOMATIC MOVEMENTS,PARKINSONS-DISEASE,PHASE-TRANSITIONS},
  language     = {eng},
  number       = {3},
  pages        = {684--694},
  title        = {Neural correlates of motor dysfunction in children with traumatic brain injury: exploration of compensatory recruitment patterns},
  url          = {http://dx.doi.org/10.1093/brain/awn344},
  volume       = {132},
  year         = {2009},
}

Chicago
Caeyenberghs, Karen, N Wenderoth, BC Smits-Engelsman, S Sunaert, and SP Swinnen. 2009. “Neural Correlates of Motor Dysfunction in Children with Traumatic Brain Injury: Exploration of Compensatory Recruitment Patterns.” Brain 132 (3): 684–694.
APA
Caeyenberghs, Karen, Wenderoth, N., Smits-Engelsman, B., Sunaert, S., & Swinnen, S. (2009). Neural correlates of motor dysfunction in children with traumatic brain injury: exploration of compensatory recruitment patterns. BRAIN, 132(3), 684–694.
Vancouver
1.
Caeyenberghs K, Wenderoth N, Smits-Engelsman B, Sunaert S, Swinnen S. Neural correlates of motor dysfunction in children with traumatic brain injury: exploration of compensatory recruitment patterns. BRAIN. 2009;132(3):684–94.
MLA
Caeyenberghs, Karen, N Wenderoth, BC Smits-Engelsman, et al. “Neural Correlates of Motor Dysfunction in Children with Traumatic Brain Injury: Exploration of Compensatory Recruitment Patterns.” BRAIN 132.3 (2009): 684–694. Print.