δ-Protocadherins: a gene family expressed differentially in the mouse brain
- Author
- Koen Vanhalst (UGent) , Patrick Kools, Katrien Staes (UGent) , Frans Van Roy (UGent) and C Redies
- Organization
- Abstract
- Phylogenetic analysis of protocadherin genes identified a new gene subfamily, the delta-protocadherins, containing several conserved motifs in their cytoplasmic domains. This subfamily can be further subdivided into two subgroups, named delta 1-protocadherins (comprising protocadherin-1, -7, -9, and -11 or X/Y) and delta 2-protocadherins (comprising protocadherin-8, -10, -17, -18, and -19). The members of the delta 1-protocadherin subgroup were analyzed in greater detail here. They share a similar gene structure that results in the expression of multiple alternative transcripts. All members of this subgroup have at least one transcript that contains a binding site for protein phosphatase-1 alpha. Like most classic cadherins, each of three delta 1-protocadherins analyzed in this study by in situ hybridization showed a unique expression pattern that differed from the patterns of the other delta 1-protocadherins. Together, these results suggest that the members of the M-protocadherin subgroup exercise tightly regulated functions in the development, regionalization, and functional differentiation of the mouse brain.
- Keywords
- cene structure, cell adhesion, alternative splicing, protein phosphatase-1 alpha, brain development, expression pattern, CENTRAL-NERVOUS-SYSTEM, CADHERIN SUPERFAMILY, PROTEIN PHOSPHATASE-1, MESSENGER-RNA, CHROMOSOMAL LOCALIZATION, OL-PROTOCADHERIN, CELL-ADHESION, IDENTIFICATION, INTERACTS, MEMBER
Downloads
-
(...).pdf
- full text
- |
- UGent only
- |
- |
- 3.55 MB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-322750
- MLA
- Vanhalst, Koen, et al. “δ-Protocadherins: A Gene Family Expressed Differentially in the Mouse Brain.” CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 62, no. 11, 2005, pp. 1247–59, doi:10.1007/s00018-005-5021-7.
- APA
- Vanhalst, K., Kools, P., Staes, K., Van Roy, F., & Redies, C. (2005). δ-Protocadherins: a gene family expressed differentially in the mouse brain. CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES, 62(11), 1247–1259. https://doi.org/10.1007/s00018-005-5021-7
- Chicago author-date
- Vanhalst, Koen, Patrick Kools, Katrien Staes, Frans Van Roy, and C Redies. 2005. “δ-Protocadherins: A Gene Family Expressed Differentially in the Mouse Brain.” CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES 62 (11): 1247–59. https://doi.org/10.1007/s00018-005-5021-7.
- Chicago author-date (all authors)
- Vanhalst, Koen, Patrick Kools, Katrien Staes, Frans Van Roy, and C Redies. 2005. “δ-Protocadherins: A Gene Family Expressed Differentially in the Mouse Brain.” CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES 62 (11): 1247–1259. doi:10.1007/s00018-005-5021-7.
- Vancouver
- 1.Vanhalst K, Kools P, Staes K, Van Roy F, Redies C. δ-Protocadherins: a gene family expressed differentially in the mouse brain. CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES. 2005;62(11):1247–59.
- IEEE
- [1]K. Vanhalst, P. Kools, K. Staes, F. Van Roy, and C. Redies, “δ-Protocadherins: a gene family expressed differentially in the mouse brain,” CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 62, no. 11, pp. 1247–1259, 2005.
@article{322750, abstract = {{Phylogenetic analysis of protocadherin genes identified a new gene subfamily, the delta-protocadherins, containing several conserved motifs in their cytoplasmic domains. This subfamily can be further subdivided into two subgroups, named delta 1-protocadherins (comprising protocadherin-1, -7, -9, and -11 or X/Y) and delta 2-protocadherins (comprising protocadherin-8, -10, -17, -18, and -19). The members of the delta 1-protocadherin subgroup were analyzed in greater detail here. They share a similar gene structure that results in the expression of multiple alternative transcripts. All members of this subgroup have at least one transcript that contains a binding site for protein phosphatase-1 alpha. Like most classic cadherins, each of three delta 1-protocadherins analyzed in this study by in situ hybridization showed a unique expression pattern that differed from the patterns of the other delta 1-protocadherins. Together, these results suggest that the members of the M-protocadherin subgroup exercise tightly regulated functions in the development, regionalization, and functional differentiation of the mouse brain.}}, author = {{Vanhalst, Koen and Kools, Patrick and Staes, Katrien and Van Roy, Frans and Redies, C}}, issn = {{1420-682X}}, journal = {{CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES}}, keywords = {{cene structure,cell adhesion,alternative splicing,protein phosphatase-1 alpha,brain development,expression pattern,CENTRAL-NERVOUS-SYSTEM,CADHERIN SUPERFAMILY,PROTEIN PHOSPHATASE-1,MESSENGER-RNA,CHROMOSOMAL LOCALIZATION,OL-PROTOCADHERIN,CELL-ADHESION,IDENTIFICATION,INTERACTS,MEMBER}}, language = {{eng}}, number = {{11}}, pages = {{1247--1259}}, title = {{δ-Protocadherins: a gene family expressed differentially in the mouse brain}}, url = {{http://doi.org/10.1007/s00018-005-5021-7}}, volume = {{62}}, year = {{2005}}, }
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: