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δ-Protocadherins: a gene family expressed differentially in the mouse brain

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Abstract
Phylogenetic analysis of protocadherin genes identified a new gene subfamily, the delta-protocadherins, containing several conserved motifs in their cytoplasmic domains. This subfamily can be further subdivided into two subgroups, named delta 1-protocadherins (comprising protocadherin-1, -7, -9, and -11 or X/Y) and delta 2-protocadherins (comprising protocadherin-8, -10, -17, -18, and -19). The members of the delta 1-protocadherin subgroup were analyzed in greater detail here. They share a similar gene structure that results in the expression of multiple alternative transcripts. All members of this subgroup have at least one transcript that contains a binding site for protein phosphatase-1 alpha. Like most classic cadherins, each of three delta 1-protocadherins analyzed in this study by in situ hybridization showed a unique expression pattern that differed from the patterns of the other delta 1-protocadherins. Together, these results suggest that the members of the M-protocadherin subgroup exercise tightly regulated functions in the development, regionalization, and functional differentiation of the mouse brain.
Keywords
cene structure, cell adhesion, alternative splicing, protein phosphatase-1 alpha, brain development, expression pattern, CENTRAL-NERVOUS-SYSTEM, CADHERIN SUPERFAMILY, PROTEIN PHOSPHATASE-1, MESSENGER-RNA, CHROMOSOMAL LOCALIZATION, OL-PROTOCADHERIN, CELL-ADHESION, IDENTIFICATION, INTERACTS, MEMBER

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MLA
Vanhalst, Koen, Patrick Kools, Katrien Staes, et al. “δ-Protocadherins: a Gene Family Expressed Differentially in the Mouse Brain.” CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES 62.11 (2005): 1247–1259. Print.
APA
Vanhalst, K., Kools, P., Staes, K., Van Roy, F., & Redies, C. (2005). δ-Protocadherins: a gene family expressed differentially in the mouse brain. CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES, 62(11), 1247–1259.
Chicago author-date
Vanhalst, Koen, Patrick Kools, Katrien Staes, Frans Van Roy, and C Redies. 2005. “δ-Protocadherins: a Gene Family Expressed Differentially in the Mouse Brain.” Cmls-cellular and Molecular Life Sciences 62 (11): 1247–1259.
Chicago author-date (all authors)
Vanhalst, Koen, Patrick Kools, Katrien Staes, Frans Van Roy, and C Redies. 2005. “δ-Protocadherins: a Gene Family Expressed Differentially in the Mouse Brain.” Cmls-cellular and Molecular Life Sciences 62 (11): 1247–1259.
Vancouver
1.
Vanhalst K, Kools P, Staes K, Van Roy F, Redies C. δ-Protocadherins: a gene family expressed differentially in the mouse brain. CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES. 2005;62(11):1247–59.
IEEE
[1]
K. Vanhalst, P. Kools, K. Staes, F. Van Roy, and C. Redies, “δ-Protocadherins: a gene family expressed differentially in the mouse brain,” CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 62, no. 11, pp. 1247–1259, 2005.
@article{322750,
  abstract     = {Phylogenetic analysis of protocadherin genes identified a new gene subfamily, the delta-protocadherins, containing several conserved motifs in their cytoplasmic domains. This subfamily can be further subdivided into two subgroups, named delta 1-protocadherins (comprising protocadherin-1, -7, -9, and -11 or X/Y) and delta 2-protocadherins (comprising protocadherin-8, -10, -17, -18, and -19). The members of the delta 1-protocadherin subgroup were analyzed in greater detail here. They share a similar gene structure that results in the expression of multiple alternative transcripts. All members of this subgroup have at least one transcript that contains a binding site for protein phosphatase-1 alpha. Like most classic cadherins, each of three delta 1-protocadherins analyzed in this study by in situ hybridization showed a unique expression pattern that differed from the patterns of the other delta 1-protocadherins. Together, these results suggest that the members of the M-protocadherin subgroup exercise tightly regulated functions in the development, regionalization, and functional differentiation of the mouse brain.},
  author       = {Vanhalst, Koen and Kools, Patrick and Staes, Katrien and Van Roy, Frans and Redies, C},
  issn         = {1420-682X},
  journal      = {CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES},
  keywords     = {cene structure,cell adhesion,alternative splicing,protein phosphatase-1 alpha,brain development,expression pattern,CENTRAL-NERVOUS-SYSTEM,CADHERIN SUPERFAMILY,PROTEIN PHOSPHATASE-1,MESSENGER-RNA,CHROMOSOMAL LOCALIZATION,OL-PROTOCADHERIN,CELL-ADHESION,IDENTIFICATION,INTERACTS,MEMBER},
  language     = {eng},
  number       = {11},
  pages        = {1247--1259},
  title        = {δ-Protocadherins: a gene family expressed differentially in the mouse brain},
  url          = {http://dx.doi.org/10.1007/s00018-005-5021-7},
  volume       = {62},
  year         = {2005},
}

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