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Soluble guanylate cyclase α₁-deficient mice: a novel murine model for primary open angle glaucoma

(2013) PLOS ONE. 8(3).
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Organization
Abstract
Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the alpha(1) subunit of the nitric oxide receptor soluble guanylate cyclase represent a novel and translatable animal model of POAG, characterized by thinning of the retinal nerve fiber layer and loss of optic nerve axons in the context of an open iridocorneal angle. The optic neuropathy associated with soluble guanylate cyclase alpha(1)-deficiency was accompanied by modestly increased intraocular pressure and retinal vascular dysfunction. Moreover, data from a candidate gene association study suggests that a variant in the locus containing the genes encoding for the alpha(1) and beta(1) subunits of soluble guanylate cyclase is associated with POAG in patients presenting with initial paracentral vision loss, a disease subtype thought to be associated with vascular dysregulation. These findings provide new insights into the pathogenesis and genetics of POAG and suggest new therapeutic strategies for POAG.
Keywords
OPTIC-NERVE HEAD, BLOOD-FLOW, OCULAR PERFUSION-PRESSURE, I COLLAGEN MUTATION, HUMOR OUTFLOW FACILITY, NITRIC-OXIDE SYNTHASE, ENDOTHELIAL DYSFUNCTION, INTRAOCULAR-PRESSURE, TRABECULAR MESHWORK, CLINICAL-TRIAL

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Chicago
Buys, Emmanuel S, Yu-Chien Ko, Clemens Alt, Sarah R Hayton, Alexander Jones, Laurel T Tainsh, Ruiyi Ren, et al. 2013. “Soluble Guanylate Cyclase Α₁-deficient Mice: a Novel Murine Model for Primary Open Angle Glaucoma.” Plos One 8 (3).
APA
Buys, E. S., Ko, Y.-C., Alt, C., Hayton, S. R., Jones, A., Tainsh, L. T., Ren, R., et al. (2013). Soluble guanylate cyclase α₁-deficient mice: a novel murine model for primary open angle glaucoma. PLOS ONE, 8(3).
Vancouver
1.
Buys ES, Ko Y-C, Alt C, Hayton SR, Jones A, Tainsh LT, et al. Soluble guanylate cyclase α₁-deficient mice: a novel murine model for primary open angle glaucoma. PLOS ONE. 2013;8(3).
MLA
Buys, Emmanuel S, Yu-Chien Ko, Clemens Alt, et al. “Soluble Guanylate Cyclase Α₁-deficient Mice: a Novel Murine Model for Primary Open Angle Glaucoma.” PLOS ONE 8.3 (2013): n. pag. Print.
@article{3226647,
  abstract     = {Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the alpha(1) subunit of the nitric oxide receptor soluble guanylate cyclase represent a novel and translatable animal model of POAG, characterized by thinning of the retinal nerve fiber layer and loss of optic nerve axons in the context of an open iridocorneal angle. The optic neuropathy associated with soluble guanylate cyclase alpha(1)-deficiency was accompanied by modestly increased intraocular pressure and retinal vascular dysfunction. Moreover, data from a candidate gene association study suggests that a variant in the locus containing the genes encoding for the alpha(1) and beta(1) subunits of soluble guanylate cyclase is associated with POAG in patients presenting with initial paracentral vision loss, a disease subtype thought to be associated with vascular dysregulation. These findings provide new insights into the pathogenesis and genetics of POAG and suggest new therapeutic strategies for POAG.},
  articleno    = {e60156},
  author       = {Buys, Emmanuel S and Ko, Yu-Chien and Alt, Clemens and Hayton, Sarah R and Jones, Alexander and Tainsh, Laurel T and Ren, Ruiyi and Giani, Andrea and Clert{\'e}, Maeva and Abernathy, Emma and Tainsh, Robert ET and Oh, Dong-Jin and Malhotra, Rajeev and Arora, Pankaj and de Waard, Nadine and Yu, Binglan and Turcotte, Raphael and Nathan, Daniel and Scherrer-Crosbie, Marielle and Loomis, Stephanie J and Kang, Jae H and Lin, Charles P and Gong, Haiyan Y and Rhee, Douglas J and Brouckaert, Peter and Wiggs, Janey L and Gregory, Meredith S and Pasquale, Louis R and Bloch, Kenneth D and Ksander, Bruce R},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {OPTIC-NERVE HEAD,BLOOD-FLOW,OCULAR PERFUSION-PRESSURE,I COLLAGEN MUTATION,HUMOR OUTFLOW FACILITY,NITRIC-OXIDE SYNTHASE,ENDOTHELIAL DYSFUNCTION,INTRAOCULAR-PRESSURE,TRABECULAR MESHWORK,CLINICAL-TRIAL},
  language     = {eng},
  number       = {3},
  pages        = {13},
  title        = {Soluble guanylate cyclase \ensuremath{\alpha}\unmatched{2081}-deficient mice: a novel murine model for primary open angle glaucoma},
  url          = {http://dx.doi.org/10.1371/journal.pone.0060156},
  volume       = {8},
  year         = {2013},
}

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