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The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression

Geert Berx (UGent) and Frans Van Roy (UGent)
(2001) BREAST CANCER RESEARCH. 3(5). p.289-293
Author
Organization
Abstract
E-cadherin is a cell-cell adhesion protein fulfilling a prominent role in epithelial differentiation. Data from model systems suggest that E-cadherin is a potent invasion/tumor suppressor of breast cancer. Consistent with this role in breast cancer progression, partial or complete loss of E-cadherin expression has been found to correlate with poor prognosis in breast cancer patients. The E-cadherin gene (CDH1) is located on human chromosome 16q22.1, a region frequently affected with loss of heterozygosity in sporadic breast cancer. Invasive lobular breast carcinomas, which are typically completely E-cadherin-negative, often show inactivating mutations in combination with loss of heterozygosity of the wild-type CDH1 allele. Mutations were found at early noninvasive stages, thus associating E-cadherin mutations with loss of cell growth control and defining CDH1 as the tumor suppressor for the lobular breast cancer subtype. Ductal breast cancers in general show heterogeneous loss of E-cadherin expression, associated with epigenetic transcriptional downregulation. It is proposed that the microenvironment at the invasive front is transiently downregulating E-cadherin transcription. This can be associated with induction of nonepithelial cadherins.
Keywords
CARCINOMA IN-SITU, TRANSCRIPTION FACTOR SNAIL, INVASION-SUPPRESSOR GENE, MAMMARY EPITHELIAL-CELLS, FAMILIAL GASTRIC-CANCER, LOBULAR CARCINOMA, P-CADHERIN, ALPHA-CATENIN, BETA-CATENIN, TUMOR-CELLS, E-cadherin, methylation, mutation, transcriptional repression, tumor suppression

Citation

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Chicago
Berx, Geert, and Frans Van Roy. 2001. “The E-cadherin/catenin Complex: An Important Gatekeeper in Breast Cancer Tumorigenesis and Malignant Progression.” Breast Cancer Research 3 (5): 289–293.
APA
Berx, G., & Van Roy, F. (2001). The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. BREAST CANCER RESEARCH, 3(5), 289–293.
Vancouver
1.
Berx G, Van Roy F. The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. BREAST CANCER RESEARCH. 2001;3(5):289–93.
MLA
Berx, Geert, and Frans Van Roy. “The E-cadherin/catenin Complex: An Important Gatekeeper in Breast Cancer Tumorigenesis and Malignant Progression.” BREAST CANCER RESEARCH 3.5 (2001): 289–293. Print.
@article{322586,
  abstract     = {E-cadherin is a cell-cell adhesion protein fulfilling a prominent role in epithelial differentiation. Data from model systems suggest that E-cadherin is a potent invasion/tumor suppressor of breast cancer. Consistent with this role in breast cancer progression, partial or complete loss of E-cadherin expression has been found to correlate with poor prognosis in breast cancer patients. The E-cadherin gene (CDH1) is located on human chromosome 16q22.1, a region frequently affected with loss of heterozygosity in sporadic breast cancer. Invasive lobular breast carcinomas, which are typically completely E-cadherin-negative, often show inactivating mutations in combination with loss of heterozygosity of the wild-type CDH1 allele. Mutations were found at early noninvasive stages, thus associating E-cadherin mutations with loss of cell growth control and defining CDH1 as the tumor suppressor for the lobular breast cancer subtype. Ductal breast cancers in general show heterogeneous loss of E-cadherin expression, associated with epigenetic transcriptional downregulation. It is proposed that the microenvironment at the invasive front is transiently downregulating E-cadherin transcription. This can be associated with induction of nonepithelial cadherins.},
  author       = {Berx, Geert and Van Roy, Frans},
  issn         = {1465-5411},
  journal      = {BREAST CANCER RESEARCH},
  keywords     = {CARCINOMA IN-SITU,TRANSCRIPTION FACTOR SNAIL,INVASION-SUPPRESSOR GENE,MAMMARY EPITHELIAL-CELLS,FAMILIAL GASTRIC-CANCER,LOBULAR CARCINOMA,P-CADHERIN,ALPHA-CATENIN,BETA-CATENIN,TUMOR-CELLS,E-cadherin,methylation,mutation,transcriptional repression,tumor suppression},
  language     = {eng},
  number       = {5},
  pages        = {289--293},
  title        = {The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression},
  url          = {http://dx.doi.org/10.1186/bcr309},
  volume       = {3},
  year         = {2001},
}

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