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Development of mechanically tailored gelatin-chondroitin sulphate hydrogel films

(2011) Macromolecular Symposia. 309-310. p.173-181
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Abstract
The aim of the present work was to develop and characterize biohybrid hydrogels containing combinations of gelatin and chondroitin sulphate. Two approaches have been compared. First, physisorption of chondroitin sulphate to gelatin hydrogels was investigated using surface plasmon resonance measurements. Due to the limited interaction between both biopolymers, we developed in a second approach methacrylate-modified chondroitin sulphate hydrogels as such or in combination with methacrylamide-modified gelatin. Rheology measurements indicated that following this approach, mechanically stable hydrogel films could be obtained after UV irradiation in the presence of Irgacure 2959 as UV photo-initiator. When keeping the gelatin concentration and the modification degree constant, an increase in derivatization of the chondroitin sulphate component resulted in a high increase of the storage modulus.
Keywords
CONTRACTION, EXTRACELLULAR-MATRIX, SCAFFOLDS, MEMBRANE, BINDING, SPONGE, characterization, chondroitin sulphate, hydrogel, gelatin, modification, COLLAGEN-GLYCOSAMINOGLYCAN MATRICES, CROSS-LINKING, IN-VITRO, RHEOLOGICAL PROPERTIES

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Citation

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Chicago
Van Vlierberghe, Sandra, Sangram Keshari Samal, and Peter Dubruel. 2011. “Development of Mechanically Tailored Gelatin-chondroitin Sulphate Hydrogel Films.” In Macromolecular Symposia, ed. A Lendlein and DW Grijpma, 309-310:173–181. Weinheim, Germany: Wiley-VCH.
APA
Van Vlierberghe, Sandra, Samal, S. K., & Dubruel, P. (2011). Development of mechanically tailored gelatin-chondroitin sulphate hydrogel films. In A Lendlein & D. Grijpma (Eds.), Macromolecular Symposia (Vol. 309–310, pp. 173–181). Presented at the 2011 Conference on Advanced Functional Polymers for Medicine (AFPM 2011), Weinheim, Germany: Wiley-VCH.
Vancouver
1.
Van Vlierberghe S, Samal SK, Dubruel P. Development of mechanically tailored gelatin-chondroitin sulphate hydrogel films. In: Lendlein A, Grijpma D, editors. Macromolecular Symposia. Weinheim, Germany: Wiley-VCH; 2011. p. 173–81.
MLA
Van Vlierberghe, Sandra, Sangram Keshari Samal, and Peter Dubruel. “Development of Mechanically Tailored Gelatin-chondroitin Sulphate Hydrogel Films.” Macromolecular Symposia. Ed. A Lendlein & DW Grijpma. Vol. 309–310. Weinheim, Germany: Wiley-VCH, 2011. 173–181. Print.
@inproceedings{3224385,
  abstract     = {The aim of the present work was to develop and characterize biohybrid hydrogels containing combinations of gelatin and chondroitin sulphate. Two approaches have been compared. First, physisorption of chondroitin sulphate to gelatin hydrogels was investigated using surface plasmon resonance measurements. Due to the limited interaction between both biopolymers, we developed in a second approach methacrylate-modified chondroitin sulphate hydrogels as such or in combination with methacrylamide-modified gelatin. Rheology measurements indicated that following this approach, mechanically stable hydrogel films could be obtained after UV irradiation in the presence of Irgacure 2959 as UV photo-initiator. When keeping the gelatin concentration and the modification degree constant, an increase in derivatization of the chondroitin sulphate component resulted in a high increase of the storage modulus.},
  author       = {Van Vlierberghe, Sandra and Samal, Sangram Keshari and Dubruel, Peter},
  booktitle    = {Macromolecular Symposia},
  editor       = {Lendlein, A and Grijpma, DW},
  issn         = {1022-1360},
  keyword      = {CONTRACTION,EXTRACELLULAR-MATRIX,SCAFFOLDS,MEMBRANE,BINDING,SPONGE,characterization,chondroitin sulphate,hydrogel,gelatin,modification,COLLAGEN-GLYCOSAMINOGLYCAN MATRICES,CROSS-LINKING,IN-VITRO,RHEOLOGICAL PROPERTIES},
  language     = {eng},
  location     = {Enschede, The Netherlands},
  pages        = {173--181},
  publisher    = {Wiley-VCH},
  title        = {Development of mechanically tailored gelatin-chondroitin sulphate hydrogel films},
  url          = {http://dx.doi.org/10.1002/masy.201100030},
  volume       = {309-310},
  year         = {2011},
}

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