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Plasma ACTH precursors in cats with pituitary-dependent hyperadrenocorticism

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Abstract
Background : Diagnosis of pituitary-dependent hyperadrenocorticism (PDH) in cats is challenging because there is no specific diagnostic test. Hypothesis/Objective : The determination of plasma ACTH precursor (POMC and pro-ACTH) concentration might facilitate the diagnosis of PDH in cats. The aim of the study was to evaluate prospectively the plasma concentrations of ACTH precursors in a small cohort of cats with PDH and to estimate the value of this approach for diagnosis. Animals Four groups of cats were included: group 1 (cats with PDH), group 2 (cats with diabetes mellitus but not hyperadrenocorticism (HAC)), group 3 (cats with diabetes mellitus and confirmed acromegaly but not HAC), and group 4 (healthy cats). Methods : PDH diagnosis was based on clinical data, low-dose dexamethasone suppression test (LDDST), and adrenal and pituitary gland computed tomography (CT) scan. For groups 2, 3, and 4, hyperadrenocorticism was excluded by LDDST or urine cortisol:creatinine ratio (UCCR). An immunoluminometric assay was used to determine plasma concentrations of ACTH precursors in the 4 groups of cats. Results : Group 1 contained 9 cats (enlarged pituitary gland in 7/9). Plasma ACTH precursor concentrations ranged from <53 to >1010 similar to pmol/L with 8/9 concentrations =229 similar to pmol/L. Groups 2, 3, and 4 included 13, 7, and 13 cats, respectively. Plasma ACTH precursor concentrations ranged from <53 to 96 similar to pmol/L in group 2, <53 to 72 similar to pmol/L in group 3, and <53 to 99 similar to pmol/L in group 4. Conclusion and Clinical Importance : High plasma concentration of ACTH precursors in cats (>100 similar to pmol/L) is highly suggestive of PDH.
Keywords
DIABETES-MELLITUS, PROOPIOMELANOCORTIN, SKIN FRAGILITY, HEALTHY CATS, Pro-opiomelanocortin, Pro-adrenocorticotropin, Feline, Cushing's disease, Corticotroph tumors, DEXAMETHASONE, HORMONE, TRILOSTANE, DOGS, ADRENALECTOMY, RESISTANCE

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Chicago
Benchekroun, G, P de Fornel-Thibaud, M Dubord, O Dossin, F Fracassi, B Rannou, F Garnier, C Maurey-Guenec, Sylvie Daminet, and D Rosenberg. 2012. “Plasma ACTH Precursors in Cats with Pituitary-dependent Hyperadrenocorticism.” Journal of Veterinary Internal Medicine 26 (3): 575–581.
APA
Benchekroun, G., de Fornel-Thibaud, P., Dubord, M., Dossin, O., Fracassi, F., Rannou, B., Garnier, F., et al. (2012). Plasma ACTH precursors in cats with pituitary-dependent hyperadrenocorticism. JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(3), 575–581.
Vancouver
1.
Benchekroun G, de Fornel-Thibaud P, Dubord M, Dossin O, Fracassi F, Rannou B, et al. Plasma ACTH precursors in cats with pituitary-dependent hyperadrenocorticism. JOURNAL OF VETERINARY INTERNAL MEDICINE. 2012;26(3):575–81.
MLA
Benchekroun, G, P de Fornel-Thibaud, M Dubord, et al. “Plasma ACTH Precursors in Cats with Pituitary-dependent Hyperadrenocorticism.” JOURNAL OF VETERINARY INTERNAL MEDICINE 26.3 (2012): 575–581. Print.
@article{3222399,
  abstract     = {Background : Diagnosis of pituitary-dependent hyperadrenocorticism (PDH) in cats is challenging because there is no specific diagnostic test.
Hypothesis/Objective : The determination of plasma ACTH precursor (POMC and pro-ACTH) concentration might facilitate the diagnosis of PDH in cats. The aim of the study was to evaluate prospectively the plasma concentrations of ACTH precursors in a small cohort of cats with PDH and to estimate the value of this approach for diagnosis. Animals Four groups of cats were included: group 1 (cats with PDH), group 2 (cats with diabetes mellitus but not hyperadrenocorticism (HAC)), group 3 (cats with diabetes mellitus and confirmed acromegaly but not HAC), and group 4 (healthy cats).
Methods : PDH diagnosis was based on clinical data, low-dose dexamethasone suppression test (LDDST), and adrenal and pituitary gland computed tomography (CT) scan. For groups 2, 3, and 4, hyperadrenocorticism was excluded by LDDST or urine cortisol:creatinine ratio (UCCR). An immunoluminometric assay was used to determine plasma concentrations of ACTH precursors in the 4 groups of cats.
Results : Group 1 contained 9 cats (enlarged pituitary gland in 7/9). Plasma ACTH precursor concentrations ranged from <53 to >1010 similar to pmol/L with 8/9 concentrations =229 similar to pmol/L. Groups 2, 3, and 4 included 13, 7, and 13 cats, respectively. Plasma ACTH precursor concentrations ranged from <53 to 96 similar to pmol/L in group 2, <53 to 72 similar to pmol/L in group 3, and <53 to 99 similar to pmol/L in group 4.
Conclusion and Clinical Importance : High plasma concentration of ACTH precursors in cats (>100 similar to pmol/L) is highly suggestive of PDH.},
  author       = {Benchekroun, G and de Fornel-Thibaud, P and Dubord, M and Dossin, O and Fracassi, F and Rannou, B and Garnier, F and Maurey-Guenec, C and Daminet, Sylvie and Rosenberg, D},
  issn         = {0891-6640},
  journal      = {JOURNAL OF VETERINARY INTERNAL MEDICINE},
  keywords     = {DIABETES-MELLITUS,PROOPIOMELANOCORTIN,SKIN FRAGILITY,HEALTHY CATS,Pro-opiomelanocortin,Pro-adrenocorticotropin,Feline,Cushing's disease,Corticotroph tumors,DEXAMETHASONE,HORMONE,TRILOSTANE,DOGS,ADRENALECTOMY,RESISTANCE},
  language     = {eng},
  number       = {3},
  pages        = {575--581},
  title        = {Plasma ACTH precursors in cats with pituitary-dependent hyperadrenocorticism},
  url          = {http://dx.doi.org/10.1111/j.1939-1676.2012.00924.x},
  volume       = {26},
  year         = {2012},
}

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