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Chronic exposure to the mycotoxin T-2 promotes oral absorption of chlortetracycline in pigs

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Abstract
The aim of this study was to investigate whether T-2 toxin, a potent Fusarium mycotoxin, affects the oral absorption of the antibiotic chlortetracycline in pigs. Animals were allocated to blank feed without T-2 toxin (controls), feed containing 111 lg T-2/kg feed, T-2-contaminated feed supplemented with a yeast-derived feed additive, or blank feed supplemented solely with the feed additive, respectively. After 21 days, an intragastric bolus of chlortetracycline was given to assess potential alterations in the pharmacokinetics of this commonly used antibiotic. A significantly higher area under the plasma concentration–time curve and maximal plasma concentration of chlortetracycline was observed after intake of T-2-contaminated feed compared with control. Thus, exposure to T-2-contaminated feed can influence the oral bioavailability of chlortetracycline. This effect could have consequences for the withdrawal time of the drug and the occurrence of undesirable residues in edible tissues.
Keywords
BIOAVAILABILITY, TOXIN, BARRIER, DEOXYNIVALENOL, DOXYCYCLINE, ALTERS

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Chicago
Goossens, Joline, Mathias Devreese, Frank Pasmans, Ann Osselaere, Siegrid De Baere, Elin Verbrugghe, Freddy Haesebrouck, Patrick De Backer, and Siska Croubels. 2013. “Chronic Exposure to the Mycotoxin T-2 Promotes Oral Absorption of Chlortetracycline in Pigs.” Journal of Veterinary Pharmacology and Therapeutics 36 (6): 621–624.
APA
Goossens, Joline, Devreese, M., Pasmans, F., Osselaere, A., De Baere, S., Verbrugghe, E., Haesebrouck, F., et al. (2013). Chronic exposure to the mycotoxin T-2 promotes oral absorption of chlortetracycline in pigs. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(6), 621–624.
Vancouver
1.
Goossens J, Devreese M, Pasmans F, Osselaere A, De Baere S, Verbrugghe E, et al. Chronic exposure to the mycotoxin T-2 promotes oral absorption of chlortetracycline in pigs. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. 2013;36(6):621–4.
MLA
Goossens, Joline, Mathias Devreese, Frank Pasmans, et al. “Chronic Exposure to the Mycotoxin T-2 Promotes Oral Absorption of Chlortetracycline in Pigs.” JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 36.6 (2013): 621–624. Print.
@article{3220258,
  abstract     = {The aim of this study was to investigate whether T-2 toxin, a potent Fusarium mycotoxin, affects the oral absorption of the antibiotic chlortetracycline in pigs. Animals were allocated to blank feed without T-2 toxin (controls), feed containing 111 lg T-2/kg feed, T-2-contaminated feed supplemented with a yeast-derived feed additive, or blank feed supplemented solely with the feed additive, respectively. After 21 days, an intragastric bolus of chlortetracycline was given to assess potential alterations in the pharmacokinetics of this commonly used antibiotic. A significantly higher area under the plasma concentration--time curve and maximal plasma concentration of chlortetracycline was observed after intake of T-2-contaminated feed compared with control. Thus, exposure to T-2-contaminated feed can influence the oral bioavailability of chlortetracycline. This effect could have consequences for the withdrawal time of the drug and the occurrence of undesirable residues in edible tissues.},
  author       = {Goossens, Joline and Devreese, Mathias and Pasmans, Frank and Osselaere, Ann and De Baere, Siegrid and Verbrugghe, Elin and Haesebrouck, Freddy and De Backer, Patrick and Croubels, Siska},
  issn         = {0140-7783},
  journal      = {JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS},
  keyword      = {BIOAVAILABILITY,TOXIN,BARRIER,DEOXYNIVALENOL,DOXYCYCLINE,ALTERS},
  language     = {eng},
  number       = {6},
  pages        = {621--624},
  title        = {Chronic exposure to the mycotoxin T-2 promotes oral absorption of chlortetracycline in pigs},
  url          = {http://dx.doi.org/10.1111/jvp.12059},
  volume       = {36},
  year         = {2013},
}

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