The effects of equine peripheral blood stem cells on cutaneous wound healing: a clinical evaluation in four horses
- Author
- Jan Spaas (UGent) , Sarah Broeckx, Gerlinde Van de Walle (UGent) and Marco Polettini
- Organization
- Abstract
- Stem-cell therapy represents a promising strategy for the treatment of challenging pathologies, such as large, infected wounds that are unresponsive to conventional therapies. The present study describes the clinical application of peripheral blood stem cells (PBSCs) for the treatment of four adult Warmblood horses with naturally occurring wounds, which were unresponsive to conventional therapies for at least 3months. A visual assessment was performed, and a number of wound-healing parameters (granulation tissue, crust formation and scar formation) were evaluated. In all cases, tissue overgrowth was visible within 4weeks after PBSC injection, followed by the formation of crusts and small scars in the centre of the wound, with hair regeneration at the edges. In conclusion, this is the first report of PBSC therapy of skin wounds in horses, and it produced a positive visual and clinical outcome.
- Keywords
- LIMBS, DISTAL ASPECT, SKIN-GRAFTS, PONIES, DRESSINGS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-3214197
- MLA
- Spaas, Jan, et al. “The Effects of Equine Peripheral Blood Stem Cells on Cutaneous Wound Healing: A Clinical Evaluation in Four Horses.” CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol. 38, no. 3, 2013, pp. 280–84, doi:10.1111/ced.12068.
- APA
- Spaas, J., Broeckx, S., Van de Walle, G., & Polettini, M. (2013). The effects of equine peripheral blood stem cells on cutaneous wound healing: a clinical evaluation in four horses. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 38(3), 280–284. https://doi.org/10.1111/ced.12068
- Chicago author-date
- Spaas, Jan, Sarah Broeckx, Gerlinde Van de Walle, and Marco Polettini. 2013. “The Effects of Equine Peripheral Blood Stem Cells on Cutaneous Wound Healing: A Clinical Evaluation in Four Horses.” CLINICAL AND EXPERIMENTAL DERMATOLOGY 38 (3): 280–84. https://doi.org/10.1111/ced.12068.
- Chicago author-date (all authors)
- Spaas, Jan, Sarah Broeckx, Gerlinde Van de Walle, and Marco Polettini. 2013. “The Effects of Equine Peripheral Blood Stem Cells on Cutaneous Wound Healing: A Clinical Evaluation in Four Horses.” CLINICAL AND EXPERIMENTAL DERMATOLOGY 38 (3): 280–284. doi:10.1111/ced.12068.
- Vancouver
- 1.Spaas J, Broeckx S, Van de Walle G, Polettini M. The effects of equine peripheral blood stem cells on cutaneous wound healing: a clinical evaluation in four horses. CLINICAL AND EXPERIMENTAL DERMATOLOGY. 2013;38(3):280–4.
- IEEE
- [1]J. Spaas, S. Broeckx, G. Van de Walle, and M. Polettini, “The effects of equine peripheral blood stem cells on cutaneous wound healing: a clinical evaluation in four horses,” CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol. 38, no. 3, pp. 280–284, 2013.
@article{3214197,
abstract = {{Stem-cell therapy represents a promising strategy for the treatment of challenging pathologies, such as large, infected wounds that are unresponsive to conventional therapies. The present study describes the clinical application of peripheral blood stem cells (PBSCs) for the treatment of four adult Warmblood horses with naturally occurring wounds, which were unresponsive to conventional therapies for at least 3months. A visual assessment was performed, and a number of wound-healing parameters (granulation tissue, crust formation and scar formation) were evaluated. In all cases, tissue overgrowth was visible within 4weeks after PBSC injection, followed by the formation of crusts and small scars in the centre of the wound, with hair regeneration at the edges. In conclusion, this is the first report of PBSC therapy of skin wounds in horses, and it produced a positive visual and clinical outcome.}},
author = {{Spaas, Jan and Broeckx, Sarah and Van de Walle, Gerlinde and Polettini, Marco}},
issn = {{0307-6938}},
journal = {{CLINICAL AND EXPERIMENTAL DERMATOLOGY}},
keywords = {{LIMBS,DISTAL ASPECT,SKIN-GRAFTS,PONIES,DRESSINGS}},
language = {{eng}},
number = {{3}},
pages = {{280--284}},
title = {{The effects of equine peripheral blood stem cells on cutaneous wound healing: a clinical evaluation in four horses}},
url = {{http://doi.org/10.1111/ced.12068}},
volume = {{38}},
year = {{2013}},
}
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