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Multiple functions of kip-related protein5 connect endoreduplication and cell elongation

(2013) PLANT PHYSIOLOGY. 161(4). p.1694-1705
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Abstract
Despite considerable progress in our knowledge regarding the cell cycle inhibitor of the Kip-related protein (KRP) family in plants, less is known about the coordination of endoreduplication and cell differentiation. In animals, the role of cyclin-dependent kinase (CDK) inhibitors as multifunctional factors coordinating cell cycle regulation and cell differentiation is well documented and involves not only the inhibition of CDK/cyclin complexes but also other mechanisms, among them the regulation of transcription. Interestingly, several plant KRPs have a punctuated distribution in the nucleus, suggesting that they are associated with heterochromatin. Here, one of these chromatin-bound KRPs, KRP5, has been studied in Arabidopsis (Arabidopsis thaliana). KRP5 is expressed in endoreduplicating cells, and loss of KRP5 function decreases endoreduplication, indicating that KRP5 is a positive regulator of endoreduplication. This regulation relies on several mechanisms: in addition to its role in cyclin/CDK kinase inhibition previously described, chromatin immunoprecipitation sequencing data combined with transcript quantification provide evidence that KRP5 regulates the transcription of genes involved in cell wall organization. Furthermore, KRP5 overexpression increases chromocenter decondensation and endoreduplication in the Arabidopsis trithorax-related protein5 (atxr5) atxr6 double mutant, which is deficient for the deposition of heterochromatin marks. Hence, KRP5 could bind chromatin to coordinately control endoreduplication and chromatin structure and allow the expression of genes required for cell elongation.
Keywords
CYCLE, PLANT DEVELOPMENT, ARABIDOPSIS-THALIANA, DEPENDENT KINASE INHIBITOR, DIFFERENTIATION, P21(WAF1/CIP1), GROWTH, EXPRESSION, SIZE, ICK1

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MLA
Jégu, Teddy, David Latrasse, Marianne Delarue, et al. “Multiple Functions of Kip-related Protein5 Connect Endoreduplication and Cell Elongation.” PLANT PHYSIOLOGY 161.4 (2013): 1694–1705. Print.
APA
Jégu, T., Latrasse, D., Delarue, M., Mazubert, C., Bourge, M., Hudik, E., Blanchet, S., et al. (2013). Multiple functions of kip-related protein5 connect endoreduplication and cell elongation. PLANT PHYSIOLOGY, 161(4), 1694–1705.
Chicago author-date
Jégu, Teddy, David Latrasse, Marianne Delarue, Christelle Mazubert, Mickaël Bourge, Elodie Hudik, Sophie Blanchet, et al. 2013. “Multiple Functions of Kip-related Protein5 Connect Endoreduplication and Cell Elongation.” Plant Physiology 161 (4): 1694–1705.
Chicago author-date (all authors)
Jégu, Teddy, David Latrasse, Marianne Delarue, Christelle Mazubert, Mickaël Bourge, Elodie Hudik, Sophie Blanchet, Marie-Noëlle Soler, Céline Charon, Lieven De Veylder, Cécile Raynaud, Catherine Bergounioux, and Moussa Benhamed. 2013. “Multiple Functions of Kip-related Protein5 Connect Endoreduplication and Cell Elongation.” Plant Physiology 161 (4): 1694–1705.
Vancouver
1.
Jégu T, Latrasse D, Delarue M, Mazubert C, Bourge M, Hudik E, et al. Multiple functions of kip-related protein5 connect endoreduplication and cell elongation. PLANT PHYSIOLOGY. 2013;161(4):1694–705.
IEEE
[1]
T. Jégu et al., “Multiple functions of kip-related protein5 connect endoreduplication and cell elongation,” PLANT PHYSIOLOGY, vol. 161, no. 4, pp. 1694–1705, 2013.
@article{3211280,
  abstract     = {Despite considerable progress in our knowledge regarding the cell cycle inhibitor of the Kip-related protein (KRP) family in plants, less is known about the coordination of endoreduplication and cell differentiation. In animals, the role of cyclin-dependent kinase (CDK) inhibitors as multifunctional factors coordinating cell cycle regulation and cell differentiation is well documented and involves not only the inhibition of CDK/cyclin complexes but also other mechanisms, among them the regulation of transcription. Interestingly, several plant KRPs have a punctuated distribution in the nucleus, suggesting that they are associated with heterochromatin. Here, one of these chromatin-bound KRPs, KRP5, has been studied in Arabidopsis (Arabidopsis thaliana). KRP5 is expressed in endoreduplicating cells, and loss of KRP5 function decreases endoreduplication, indicating that KRP5 is a positive regulator of endoreduplication. This regulation relies on several mechanisms: in addition to its role in cyclin/CDK kinase inhibition previously described, chromatin immunoprecipitation sequencing data combined with transcript quantification provide evidence that KRP5 regulates the transcription of genes involved in cell wall organization. Furthermore, KRP5 overexpression increases chromocenter decondensation and endoreduplication in the Arabidopsis trithorax-related protein5 (atxr5) atxr6 double mutant, which is deficient for the deposition of heterochromatin marks. Hence, KRP5 could bind chromatin to coordinately control endoreduplication and chromatin structure and allow the expression of genes required for cell elongation.},
  author       = {Jégu, Teddy and Latrasse, David and Delarue, Marianne and Mazubert, Christelle and Bourge, Mickaël and Hudik, Elodie and Blanchet, Sophie and Soler, Marie-Noëlle and Charon, Céline and De Veylder, Lieven and Raynaud, Cécile and Bergounioux, Catherine and Benhamed, Moussa},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  keywords     = {CYCLE,PLANT DEVELOPMENT,ARABIDOPSIS-THALIANA,DEPENDENT KINASE INHIBITOR,DIFFERENTIATION,P21(WAF1/CIP1),GROWTH,EXPRESSION,SIZE,ICK1},
  language     = {eng},
  number       = {4},
  pages        = {1694--1705},
  title        = {Multiple functions of kip-related protein5 connect endoreduplication and cell elongation},
  url          = {http://dx.doi.org/10.1104/pp.112.212357},
  volume       = {161},
  year         = {2013},
}

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