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SCFTIR1/AFB-auxin signalling regulates PIN vacuolar trafficking and auxin fluxes during root gravitropism

Pawel Radoslaw Baster, Stephanie Robert UGent, Jürgen Kleine-Vehn UGent, Steffen Vanneste UGent, Urszula Kania, Wim Grunewald UGent, Bert De Rybel UGent, Tom Beeckman UGent and Jiri Friml (2013) EMBO JOURNAL. 32(2). p.260-274
abstract
The distribution of the phytohormone auxin regulates many aspects of plant development including growth response to gravity. Gravitropic root curvature involves coordinated and asymmetric cell elongation between the lower and upper side of the root, mediated by differential cellular auxin levels. The asymmetry in the auxin distribution is established and maintained by a spatio-temporal regulation of the PIN-FORMED (PIN) auxin transporter activity. We provide novel insights into the complex regulation of PIN abundance and activity during root gravitropism. We show that PIN2 turnover is differentially regulated on the upper and lower side of gravistimulated roots by distinct but partially overlapping auxin feedback mechanisms. In addition to regulating transcription and clathrin-mediated internalization, auxin also controls PIN abundance at the plasma membrane by promoting their vacuolar targeting and degradation. This effect of elevated auxin levels requires the activity of SKP-Cullin-F-box(TIR1/AFB) (SCFTIR1/AFB)-dependent pathway. Importantly, also suboptimal auxin levels mediate PIN degradation utilizing the same signalling pathway. These feedback mechanisms are functionally important during gravitropic response and ensure fine-tuning of auxin fluxes for maintaining as well as terminating asymmetric growth.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
PLANT DEVELOPMENT, PLASMA-MEMBRANE, ARABIDOPSIS-THALIANA, BOX PROTEIN TIR1, FACTOR GENE FAMILY, YUCCA FLAVIN MONOOXYGENASES, EFFLUX CARRIER POLARITY, PIN, gravitropism, degradation, auxin, BINDING-PROTEIN, DEPENDENT ENDOCYTOSIS, UBIQUITIN LIGASE
journal title
EMBO JOURNAL
Embo J.
volume
32
issue
2
pages
260 - 274
Web of Science type
Review
Web of Science id
000316464500009
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
10.748 (2013)
JCR rank
15/291 (2013)
JCR quartile
1 (2013)
ISSN
0261-4189
DOI
10.1038/emboj.2012.310
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3202591
handle
http://hdl.handle.net/1854/LU-3202591
date created
2013-04-26 11:08:57
date last changed
2016-12-19 15:40:06
@article{3202591,
  abstract     = {The distribution of the phytohormone auxin regulates many aspects of plant development including growth response to gravity. Gravitropic root curvature involves coordinated and asymmetric cell elongation between the lower and upper side of the root, mediated by differential cellular auxin levels. The asymmetry in the auxin distribution is established and maintained by a spatio-temporal regulation of the PIN-FORMED (PIN) auxin transporter activity. We provide novel insights into the complex regulation of PIN abundance and activity during root gravitropism. We show that PIN2 turnover is differentially regulated on the upper and lower side of gravistimulated roots by distinct but partially overlapping auxin feedback mechanisms. In addition to regulating transcription and clathrin-mediated internalization, auxin also controls PIN abundance at the plasma membrane by promoting their vacuolar targeting and degradation. This effect of elevated auxin levels requires the activity of SKP-Cullin-F-box(TIR1/AFB) (SCFTIR1/AFB)-dependent pathway. Importantly, also suboptimal auxin levels mediate PIN degradation utilizing the same signalling pathway. These feedback mechanisms are functionally important during gravitropic response and ensure fine-tuning of auxin fluxes for maintaining as well as terminating asymmetric growth.},
  author       = {Baster, Pawel Radoslaw and Robert, Stephanie and Kleine-Vehn, J{\"u}rgen and Vanneste, Steffen and Kania, Urszula and Grunewald, Wim and De Rybel, Bert and Beeckman, Tom and Friml, Jiri},
  issn         = {0261-4189},
  journal      = {EMBO JOURNAL},
  keyword      = {PLANT DEVELOPMENT,PLASMA-MEMBRANE,ARABIDOPSIS-THALIANA,BOX PROTEIN TIR1,FACTOR GENE FAMILY,YUCCA FLAVIN MONOOXYGENASES,EFFLUX CARRIER POLARITY,PIN,gravitropism,degradation,auxin,BINDING-PROTEIN,DEPENDENT ENDOCYTOSIS,UBIQUITIN LIGASE},
  language     = {eng},
  number       = {2},
  pages        = {260--274},
  title        = {SCFTIR1/AFB-auxin signalling regulates PIN vacuolar trafficking and auxin fluxes during root gravitropism},
  url          = {http://dx.doi.org/10.1038/emboj.2012.310},
  volume       = {32},
  year         = {2013},
}

Chicago
Baster, Pawel Radoslaw, Stephanie Robert, Jürgen Kleine-Vehn, Steffen Vanneste, Urszula Kania, Wim Grunewald, Bert De Rybel, Tom Beeckman, and Jiri Friml. 2013. “SCFTIR1/AFB-auxin Signalling Regulates PIN Vacuolar Trafficking and Auxin Fluxes During Root Gravitropism.” Embo Journal 32 (2): 260–274.
APA
Baster, P. R., Robert, S., Kleine-Vehn, J., Vanneste, S., Kania, U., Grunewald, W., De Rybel, B., et al. (2013). SCFTIR1/AFB-auxin signalling regulates PIN vacuolar trafficking and auxin fluxes during root gravitropism. EMBO JOURNAL, 32(2), 260–274.
Vancouver
1.
Baster PR, Robert S, Kleine-Vehn J, Vanneste S, Kania U, Grunewald W, et al. SCFTIR1/AFB-auxin signalling regulates PIN vacuolar trafficking and auxin fluxes during root gravitropism. EMBO JOURNAL. 2013;32(2):260–74.
MLA
Baster, Pawel Radoslaw, Stephanie Robert, Jürgen Kleine-Vehn, et al. “SCFTIR1/AFB-auxin Signalling Regulates PIN Vacuolar Trafficking and Auxin Fluxes During Root Gravitropism.” EMBO JOURNAL 32.2 (2013): 260–274. Print.