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Normal spirometry values in healthy elderly: the Rotterdam Study

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Abstract
Although many different reference values for spirometry are available from various studies, the elderly are usually underrepresented. Therefore, our objective was to assess reference values in a sample of healthy participants from a prospective population-based cohort study, including a large proportion of elderly. We included spirometry measurements of healthy, never smokers, from the Rotterdam Study and excluded participants with respiratory symptoms or prescriptions for respiratory medication. Age- and height-specific curves for the 5th (lower limit of normal) and the 50th (median) percentile of Forced Expiratory Volume in 1 s (FEV1), Forced Vital Capacity (FVC), and the ratio (FEV1/FVC) were calculated by quantile regression models. The group of healthy elderly study subjects consisted of 1,125 individuals, with a mean age of 68 years, ranging from 47 to 96 years of age. Sex stratified equations for the median and the lower limit of normal were calculated adjusted for age and height. In this study, we report age- and height-dependent reference limits for FEV1, FVC, and FEV1/FVC in a large population, and prediction equations for the lower limit of normal and median values for a sample containing a large proportion of healthy elderly.
Keywords
FVC, FEV1, FEV1/FVC, Spirometry, Elderly, Reference equations, Population studies, IMPAIRED LUNG-FUNCTION, INTERPRETATIVE STRATEGIES, PULMONARY-FUNCTION, POPULATION, MORTALITY, EQUATIONS, DISEASE, RISK, COPD

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MLA
Loth, Daan Willem, Till Ittermann, Lies Lahousse, et al. “Normal Spirometry Values in Healthy Elderly: The Rotterdam Study.” EUROPEAN JOURNAL OF EPIDEMIOLOGY 28.4 (2013): 329–334. Print.
APA
Loth, Daan Willem, Ittermann, T., Lahousse, L., Hofman, A., Leufkens, H. G. M., Brusselle, G., & Stricker, B. H. (2013). Normal spirometry values in healthy elderly: the Rotterdam Study. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 28(4), 329–334.
Chicago author-date
Loth, Daan Willem, Till Ittermann, Lies Lahousse, Albert Hofman, Hubert Gerardus Maria Leufkens, Guy Brusselle, and Bruno Hugo Stricker. 2013. “Normal Spirometry Values in Healthy Elderly: The Rotterdam Study.” European Journal of Epidemiology 28 (4): 329–334.
Chicago author-date (all authors)
Loth, Daan Willem, Till Ittermann, Lies Lahousse, Albert Hofman, Hubert Gerardus Maria Leufkens, Guy Brusselle, and Bruno Hugo Stricker. 2013. “Normal Spirometry Values in Healthy Elderly: The Rotterdam Study.” European Journal of Epidemiology 28 (4): 329–334.
Vancouver
1.
Loth DW, Ittermann T, Lahousse L, Hofman A, Leufkens HGM, Brusselle G, et al. Normal spirometry values in healthy elderly: the Rotterdam Study. EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2013;28(4):329–34.
IEEE
[1]
D. W. Loth et al., “Normal spirometry values in healthy elderly: the Rotterdam Study,” EUROPEAN JOURNAL OF EPIDEMIOLOGY, vol. 28, no. 4, pp. 329–334, 2013.
@article{3195886,
  abstract     = {Although many different reference values for spirometry are available from various studies, the elderly are usually underrepresented. Therefore, our objective was to assess reference values in a sample of healthy participants from a prospective population-based cohort study, including a large proportion of elderly. We included spirometry measurements of healthy, never smokers, from the Rotterdam Study and excluded participants with respiratory symptoms or prescriptions for respiratory medication. Age- and height-specific curves for the 5th (lower limit of normal) and the 50th (median) percentile of Forced Expiratory Volume in 1 s (FEV1), Forced Vital Capacity (FVC), and the ratio (FEV1/FVC) were calculated by quantile regression models. The group of healthy elderly study subjects consisted of 1,125 individuals, with a mean age of 68 years, ranging from 47 to 96 years of age. Sex stratified equations for the median and the lower limit of normal were calculated adjusted for age and height. In this study, we report age- and height-dependent reference limits for FEV1, FVC, and FEV1/FVC in a large population, and prediction equations for the lower limit of normal and median values for a sample containing a large proportion of healthy elderly.},
  author       = {Loth, Daan Willem and Ittermann, Till and Lahousse, Lies and Hofman, Albert and Leufkens, Hubert Gerardus Maria and Brusselle, Guy and Stricker, Bruno Hugo},
  issn         = {0393-2990},
  journal      = {EUROPEAN JOURNAL OF EPIDEMIOLOGY},
  keywords     = {FVC,FEV1,FEV1/FVC,Spirometry,Elderly,Reference equations,Population studies,IMPAIRED LUNG-FUNCTION,INTERPRETATIVE STRATEGIES,PULMONARY-FUNCTION,POPULATION,MORTALITY,EQUATIONS,DISEASE,RISK,COPD},
  language     = {eng},
  number       = {4},
  pages        = {329--334},
  title        = {Normal spirometry values in healthy elderly: the Rotterdam Study},
  url          = {http://dx.doi.org/10.1007/s10654-013-9800-4},
  volume       = {28},
  year         = {2013},
}

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