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Screening of ragdoll cats for kidney-disease: a retrospective evaluation

Dominique Paepe (UGent) , Jimmy Saunders (UGent) , Valérie Bavegems (UGent) , Geert Paes (UGent) , Luc Peelman (UGent) , Caroline Makay (UGent) and Sylvie Daminet (UGent)
(2012) JOURNAL OF SMALL ANIMAL PRACTICE. 53(10). p.572-577
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Abstract
Objectives To assess the prevalence of renal abnormalities in ragdoll cats. Ragdoll breeders often warn clients to watch for future renal problems, mainly due to chronic interstitial nephritis and polycystic kidney disease. Therefore, ragdoll screening by abdominal ultrasonography, measurement of serum creatinine and urea concentrations and genetic testing is often performed without documented scientific evidence of increased risk of renal disease. Methods Retrospective evaluation of ragdoll screening for renal disease at one institution over an eight-year period. Results Renal ultrasonography was performed in 244 healthy ragdoll cats. Seven cats were positive for polycystic kidney disease, 21 were suspected to have chronic kidney disease, 8 had abnormalities of unknown significance and 2 cats had only one visible kidney. Cats suspected to have chronic kidney disease were significantly older and had significantly higher serum urea and creatinine concentrations than cats with normal renal ultrasonography. All 125 genetically tested cats were negative for polycystic kidney disease. However, only one of the seven ultrasonographically positive cats underwent genetic testing for polycystic kidney disease. Clinical Significance Ultrasonographic findings compatible with chronic kidney disease were observed in almost 10% of cats, and polycystic kidney disease occurred at a low prevalence (<3%) in this ragdoll population. Further studies are required to elucidate if ragdoll cats are predisposed to chronic kidney disease.
Keywords
REFERENCE INTERVALS, MUTATION, DYSPLASIA, URINARY-TRACT, SMALL ANIMALS, PERSIAN CATS, PREVALENCE, ULTRASONOGRAPHY, UNILATERAL RENAL AGENESIS, ABNORMALITIES

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Chicago
Paepe, Dominique, Jimmy Saunders, Valérie Bavegems, Geert Paes, Luc Peelman, Caroline Makay, and Sylvie Daminet. 2012. “Screening of Ragdoll Cats for Kidney-disease: a Retrospective Evaluation.” Journal of Small Animal Practice 53 (10): 572–577.
APA
Paepe, Dominique, Saunders, J., Bavegems, V., Paes, G., Peelman, L., Makay, C., & Daminet, S. (2012). Screening of ragdoll cats for kidney-disease: a retrospective evaluation. JOURNAL OF SMALL ANIMAL PRACTICE, 53(10), 572–577.
Vancouver
1.
Paepe D, Saunders J, Bavegems V, Paes G, Peelman L, Makay C, et al. Screening of ragdoll cats for kidney-disease: a retrospective evaluation. JOURNAL OF SMALL ANIMAL PRACTICE. 2012;53(10):572–7.
MLA
Paepe, Dominique, Jimmy Saunders, Valérie Bavegems, et al. “Screening of Ragdoll Cats for Kidney-disease: a Retrospective Evaluation.” JOURNAL OF SMALL ANIMAL PRACTICE 53.10 (2012): 572–577. Print.
@article{3188042,
  abstract     = {Objectives To assess the prevalence of renal abnormalities in ragdoll cats. Ragdoll breeders often warn clients to watch for future renal problems, mainly due to chronic interstitial nephritis and polycystic kidney disease. Therefore, ragdoll screening by abdominal ultrasonography, measurement of serum creatinine and urea concentrations and genetic testing is often performed without documented scientific evidence of increased risk of renal disease. Methods Retrospective evaluation of ragdoll screening for renal disease at one institution over an eight-year period. Results Renal ultrasonography was performed in 244 healthy ragdoll cats. Seven cats were positive for polycystic kidney disease, 21 were suspected to have chronic kidney disease, 8 had abnormalities of unknown significance and 2 cats had only one visible kidney. Cats suspected to have chronic kidney disease were significantly older and had significantly higher serum urea and creatinine concentrations than cats with normal renal ultrasonography. All 125 genetically tested cats were negative for polycystic kidney disease. However, only one of the seven ultrasonographically positive cats underwent genetic testing for polycystic kidney disease. Clinical Significance Ultrasonographic findings compatible with chronic kidney disease were observed in almost 10% of cats, and polycystic kidney disease occurred at a low prevalence (<3%) in this ragdoll population. Further studies are required to elucidate if ragdoll cats are predisposed to chronic kidney disease.},
  author       = {Paepe, Dominique and Saunders, Jimmy and Bavegems, Valérie and Paes, Geert and Peelman, Luc and Makay, Caroline and Daminet, Sylvie},
  issn         = {0022-4510},
  journal      = {JOURNAL OF SMALL ANIMAL PRACTICE},
  keywords     = {REFERENCE INTERVALS,MUTATION,DYSPLASIA,URINARY-TRACT,SMALL ANIMALS,PERSIAN CATS,PREVALENCE,ULTRASONOGRAPHY,UNILATERAL RENAL AGENESIS,ABNORMALITIES},
  language     = {eng},
  number       = {10},
  pages        = {572--577},
  title        = {Screening of ragdoll cats for kidney-disease: a retrospective evaluation},
  url          = {http://dx.doi.org/10.1111/j.1748-5827.2012.01254.x},
  volume       = {53},
  year         = {2012},
}

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