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The condition-dependent transcriptional network in Escherichia coli

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Abstract
Thanks to the availability of high-throughput omics data, bioinformatics approaches are able to hypothesize thus-far undocumented genetic interactions. However, due to the amount of noise in these data, inferences based on a single data source are often unreliable. A popular approach to overcome this problem is to integrate different data sources. In this study, we describe DISTILLER, a novel frame work for data integration that simultaneously analyzes microarray and motif information to find modules that: consist. of genes that are co-expressed in a subset of conditions, and their corresponding regulators. By applying our method on publicly available data, we evaluated the condition-specific transcriptional network of Escherichia coli. DISTILLER confirmed 62% of 736 interactions described in RegulonDB, and 278 novel interactions v,,ere predicted.
Keywords
REGULATORY NETWORK, EXPRESSION PROFILES, frequent itemset mining, DISTILLER, transcriptional modules, DATABASE, TOOLS

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MLA
Lemmens, Karen, et al. “The Condition-Dependent Transcriptional Network in Escherichia Coli.” Annals of the New York Academy of Sciences, edited by G Stolovitzky et al., vol. 1158, Wiley-Blackwell, 2009, pp. 29–35, doi:10.1111/j.1749-6632.2008.03746.x.
APA
Lemmens, K., De Bie, T., Dhollander, T., Monsieurs, P., De Moor, B., Collado-Vides, J., … Marchal, K. (2009). The condition-dependent transcriptional network in Escherichia coli. Annals of the New York Academy of Sciences, 1158, 29–35. https://doi.org/10.1111/j.1749-6632.2008.03746.x
Chicago author-date
Lemmens, Karen, Tijl De Bie, Thomas Dhollander, Pieter Monsieurs, Bart De Moor, Julio Collado-Vides, Kristof Engelen, and Kathleen Marchal. 2009. “The Condition-Dependent Transcriptional Network in Escherichia Coli.” Edited by G Stolovitzky, P Kahlem, and A Califano. Annals of the New York Academy of Sciences 1158: 29–35. https://doi.org/10.1111/j.1749-6632.2008.03746.x.
Chicago author-date (all authors)
Lemmens, Karen, Tijl De Bie, Thomas Dhollander, Pieter Monsieurs, Bart De Moor, Julio Collado-Vides, Kristof Engelen, and Kathleen Marchal. 2009. “The Condition-Dependent Transcriptional Network in Escherichia Coli.” Ed by. G Stolovitzky, P Kahlem, and A Califano. Annals of the New York Academy of Sciences 1158: 29–35. doi:10.1111/j.1749-6632.2008.03746.x.
Vancouver
1.
Lemmens K, De Bie T, Dhollander T, Monsieurs P, De Moor B, Collado-Vides J, et al. The condition-dependent transcriptional network in Escherichia coli. Stolovitzky G, Kahlem P, Califano A, editors. Annals of the New York Academy of Sciences. 2009;1158:29–35.
IEEE
[1]
K. Lemmens et al., “The condition-dependent transcriptional network in Escherichia coli,” Annals of the New York Academy of Sciences, vol. 1158, pp. 29–35, 2009.
@article{3186950,
  abstract     = {{Thanks to the availability of high-throughput omics data, bioinformatics approaches are able to hypothesize thus-far undocumented genetic interactions. However, due to the amount of noise in these data, inferences based on a single data source are often unreliable. A popular approach to overcome this problem is to integrate different data sources. In this study, we describe DISTILLER, a novel frame work for data integration that simultaneously analyzes microarray and motif information to find modules that: consist. of genes that are co-expressed in a subset of conditions, and their corresponding regulators. By applying our method on publicly available data, we evaluated the condition-specific transcriptional network of Escherichia coli. DISTILLER confirmed 62% of 736 interactions described in RegulonDB, and 278 novel interactions v,,ere predicted.}},
  author       = {{Lemmens, Karen and De Bie, Tijl and Dhollander, Thomas and Monsieurs, Pieter and De Moor, Bart and Collado-Vides, Julio and Engelen, Kristof and Marchal, Kathleen}},
  editor       = {{Stolovitzky, G and Kahlem, P and Califano, A}},
  isbn         = {{9781573317511}},
  issn         = {{0077-8923}},
  journal      = {{Annals of the New York Academy of Sciences}},
  keywords     = {{REGULATORY NETWORK,EXPRESSION PROFILES,frequent itemset mining,DISTILLER,transcriptional modules,DATABASE,TOOLS}},
  language     = {{eng}},
  location     = {{Madrid, Spain}},
  pages        = {{29--35}},
  publisher    = {{Wiley-Blackwell}},
  title        = {{The condition-dependent transcriptional network in Escherichia coli}},
  url          = {{http://doi.org/10.1111/j.1749-6632.2008.03746.x}},
  volume       = {{1158}},
  year         = {{2009}},
}

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