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DISTILLER: a data integration framework to reveal condition dependency of complex regulons in Escherichia coli

Karen Lemmens, Tijl De Bie (UGent) , Thomas Dhollander, Sigrid CJ De Keersmaecker, Inge M Thijs, Geert Schoofs, Ami De Weerdt, Bart De Moor, Jos Vanderleyden, Julio Collado-Vides, et al.
(2009) GENOME BIOLOGY. 10(3).
Author
Organization
Abstract
We present DISTILLER, a data integration framework for the inference of transcriptional module networks. Experimental validation of predicted targets for the well-studied fumarate nitrate reductase regulator showed the effectiveness of our approach in Escherichia coli. In addition, the condition dependency and modularity of the inferred transcriptional network was studied. Surprisingly, the level of regulatory complexity seemed lower than that which would be expected from RegulonDB, indicating that complex regulatory programs tend to decrease the degree of modularity.
Keywords
EXPRESSION PROFILES, DNA-BINDING, GLOBAL REGULATORS, TRANSCRIPTIONAL REGULATORY NETWORK, ART. NO. E15, GENE, LOW-PH, MICROARRAY DATA, FNR, PROTEIN

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MLA
Lemmens, Karen, et al. “DISTILLER: A Data Integration Framework to Reveal Condition Dependency of Complex Regulons in Escherichia Coli.” GENOME BIOLOGY, vol. 10, no. 3, 2009, doi:10.1186/gb-2009-10-3-r27.
APA
Lemmens, K., De Bie, T., Dhollander, T., De Keersmaecker, S. C., Thijs, I. M., Schoofs, G., … Marchal, K. (2009). DISTILLER: a data integration framework to reveal condition dependency of complex regulons in Escherichia coli. GENOME BIOLOGY, 10(3). https://doi.org/10.1186/gb-2009-10-3-r27
Chicago author-date
Lemmens, Karen, Tijl De Bie, Thomas Dhollander, Sigrid CJ De Keersmaecker, Inge M Thijs, Geert Schoofs, Ami De Weerdt, et al. 2009. “DISTILLER: A Data Integration Framework to Reveal Condition Dependency of Complex Regulons in Escherichia Coli.” GENOME BIOLOGY 10 (3). https://doi.org/10.1186/gb-2009-10-3-r27.
Chicago author-date (all authors)
Lemmens, Karen, Tijl De Bie, Thomas Dhollander, Sigrid CJ De Keersmaecker, Inge M Thijs, Geert Schoofs, Ami De Weerdt, Bart De Moor, Jos Vanderleyden, Julio Collado-Vides, Kristof Engelen, and Kathleen Marchal. 2009. “DISTILLER: A Data Integration Framework to Reveal Condition Dependency of Complex Regulons in Escherichia Coli.” GENOME BIOLOGY 10 (3). doi:10.1186/gb-2009-10-3-r27.
Vancouver
1.
Lemmens K, De Bie T, Dhollander T, De Keersmaecker SC, Thijs IM, Schoofs G, et al. DISTILLER: a data integration framework to reveal condition dependency of complex regulons in Escherichia coli. GENOME BIOLOGY. 2009;10(3).
IEEE
[1]
K. Lemmens et al., “DISTILLER: a data integration framework to reveal condition dependency of complex regulons in Escherichia coli,” GENOME BIOLOGY, vol. 10, no. 3, 2009.
@article{3186937,
  abstract     = {{We present DISTILLER, a data integration framework for the inference of transcriptional module networks. Experimental validation of predicted targets for the well-studied fumarate nitrate reductase regulator showed the effectiveness of our approach in Escherichia coli. In addition, the condition dependency and modularity of the inferred transcriptional network was studied. Surprisingly, the level of regulatory complexity seemed lower than that which would be expected from RegulonDB, indicating that complex regulatory programs tend to decrease the degree of modularity.}},
  articleno    = {{R27}},
  author       = {{Lemmens, Karen and De Bie, Tijl and Dhollander, Thomas and De Keersmaecker, Sigrid CJ and Thijs, Inge M and Schoofs, Geert and De Weerdt, Ami and De Moor, Bart and Vanderleyden, Jos and Collado-Vides, Julio and Engelen, Kristof and Marchal, Kathleen}},
  issn         = {{1474-760X}},
  journal      = {{GENOME BIOLOGY}},
  keywords     = {{EXPRESSION PROFILES,DNA-BINDING,GLOBAL REGULATORS,TRANSCRIPTIONAL REGULATORY NETWORK,ART. NO. E15,GENE,LOW-PH,MICROARRAY DATA,FNR,PROTEIN}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{13}},
  title        = {{DISTILLER: a data integration framework to reveal condition dependency of complex regulons in Escherichia coli}},
  url          = {{http://dx.doi.org/10.1186/gb-2009-10-3-r27}},
  volume       = {{10}},
  year         = {{2009}},
}
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