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Efficient and catalyst-free condensation of acid chlorides and alcohols using continuous flow

(2012) GREEN CHEMISTRY. 14(10). p.2776-2779
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Abstract
An efficient, catalyst-free continuous flow procedure for the condensation of acid chlorides and alcohols was developed. Different esters could be obtained using this protocol with excellent conversions starting from the corresponding acid chlorides and alcohols in very short reaction times (5-7 min). The reaction was performed solventless for liquid reagents but requires a solvent for solid reagents in order to prevent clogging of the microreactor. Since no catalyst is needed, the purification of the reaction mixture is very straightforward. Scale-up of the reaction to a microreactor with an internal volume of 13.8 ml makes it possible to produce 2.2 g min(-1) of ester with an isolated yield of 98% and recuperation of the formed HCl.
Keywords
ACYLATION, BENZOYLATION, ESTERIFICATION REACTION, MICROREACTOR CONDITIONS, ZINC-OXIDE, SOLVENT-FREE CONDITIONS, ACETYL-CHLORIDE, HIGHLY EFFICIENT, PHENOLS, AMINES

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Citation

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Chicago
Van Waes, Frederik, J Drabowicz, Ana Cukalovic, and Christian Stevens. 2012. “Efficient and Catalyst-free Condensation of Acid Chlorides and Alcohols Using Continuous Flow.” Green Chemistry 14 (10): 2776–2779.
APA
Van Waes, F., Drabowicz, J., Cukalovic, A., & Stevens, C. (2012). Efficient and catalyst-free condensation of acid chlorides and alcohols using continuous flow. GREEN CHEMISTRY, 14(10), 2776–2779.
Vancouver
1.
Van Waes F, Drabowicz J, Cukalovic A, Stevens C. Efficient and catalyst-free condensation of acid chlorides and alcohols using continuous flow. GREEN CHEMISTRY. 2012;14(10):2776–9.
MLA
Van Waes, Frederik, J Drabowicz, Ana Cukalovic, et al. “Efficient and Catalyst-free Condensation of Acid Chlorides and Alcohols Using Continuous Flow.” GREEN CHEMISTRY 14.10 (2012): 2776–2779. Print.
@article{3183995,
  abstract     = {An efficient, catalyst-free continuous flow procedure for the condensation of acid chlorides and alcohols was developed. Different esters could be obtained using this protocol with excellent conversions starting from the corresponding acid chlorides and alcohols in very short reaction times (5-7 min). The reaction was performed solventless for liquid reagents but requires a solvent for solid reagents in order to prevent clogging of the microreactor. Since no catalyst is needed, the purification of the reaction mixture is very straightforward. Scale-up of the reaction to a microreactor with an internal volume of 13.8 ml makes it possible to produce 2.2 g min(-1) of ester with an isolated yield of 98\% and recuperation of the formed HCl.},
  author       = {Van Waes, Frederik and Drabowicz, J and Cukalovic, Ana and Stevens, Christian},
  issn         = {1463-9262},
  journal      = {GREEN CHEMISTRY},
  keyword      = {ACYLATION,BENZOYLATION,ESTERIFICATION REACTION,MICROREACTOR CONDITIONS,ZINC-OXIDE,SOLVENT-FREE CONDITIONS,ACETYL-CHLORIDE,HIGHLY EFFICIENT,PHENOLS,AMINES},
  language     = {eng},
  number       = {10},
  pages        = {2776--2779},
  title        = {Efficient and catalyst-free condensation of acid chlorides and alcohols using continuous flow},
  url          = {http://dx.doi.org/10.1039/c2gc35555h},
  volume       = {14},
  year         = {2012},
}

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