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Hepatic progenitor cells in hepatocellular adenomas

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Abstract
Hepatocellular adenoma is a benign tumor of the liver that has a small but not negligible risk of malignant transformation into hepatocellular carcinoma. In analogy with the established role of oval cells in hepatocarcinogenesis in rodent models, human hepatic progenitor cells may have a function in the development of liver tumors. To investigate this issue, we performed immunohistochemistry on biopsies of 10 consecutively resected hepatocellular adenomas using mark ers for hepatic progenitor cells. Sections of paraffin-embedded and frozen biopsies were stained using antibodies against cytokeratins 7, 8, 18, and 19, chromogranin-A, OV-6, and neural cell adhesion molecule. Hepatic progenitor cells were observed in five of 10 hepatocellular adenomas. These five tumors also contained cells with an immunohistochemical phenotype intermediate be tween hepatic progenitor cells and hepatocytes. Hepatic progenitor cells and intermediate hepatocyte-like cells were scattered throughout the tumors with a density that varied from area to area. Ultrastructural examination confirmed the presence of hepatic progenitor cells. Our study shows that hepatic progenitor cells are present in a considerable proportion of hepatocellular adenomas, supporting the hypothesis that human hepatic progenitor cells can play a role in the development of heptocellular tumors.
Keywords
hepatic progenitor cell, hepatocellular adenoma, oval cell, liver tumor development, immunohistochemistry, FOCAL NODULAR HYPERPLASIA, STEM-CELLS, RAT-LIVER, OVAL CELL, ORAL-CONTRACEPTIVES, DUCTULAR REACTION, EPITHELIAL-CELLS, EXPRESSION, CARCINOMA, DIFFERENTIATION

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MLA
Libbrecht, Louis, Rita De Vos, David Cassiman, et al. “Hepatic Progenitor Cells in Hepatocellular Adenomas.” AMERICAN JOURNAL OF SURGICAL PATHOLOGY 25.11 (2001): 1388–1396. Print.
APA
Libbrecht, L., De Vos, R., Cassiman, D., Desmet, V., Aerts, R., & Roskams, T. (2001). Hepatic progenitor cells in hepatocellular adenomas. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 25(11), 1388–1396.
Chicago author-date
Libbrecht, Louis, Rita De Vos, David Cassiman, Valeer Desmet, Raymond Aerts, and Tania Roskams. 2001. “Hepatic Progenitor Cells in Hepatocellular Adenomas.” American Journal of Surgical Pathology 25 (11): 1388–1396.
Chicago author-date (all authors)
Libbrecht, Louis, Rita De Vos, David Cassiman, Valeer Desmet, Raymond Aerts, and Tania Roskams. 2001. “Hepatic Progenitor Cells in Hepatocellular Adenomas.” American Journal of Surgical Pathology 25 (11): 1388–1396.
Vancouver
1.
Libbrecht L, De Vos R, Cassiman D, Desmet V, Aerts R, Roskams T. Hepatic progenitor cells in hepatocellular adenomas. AMERICAN JOURNAL OF SURGICAL PATHOLOGY. 2001;25(11):1388–96.
IEEE
[1]
L. Libbrecht, R. De Vos, D. Cassiman, V. Desmet, R. Aerts, and T. Roskams, “Hepatic progenitor cells in hepatocellular adenomas,” AMERICAN JOURNAL OF SURGICAL PATHOLOGY, vol. 25, no. 11, pp. 1388–1396, 2001.
@article{3183186,
  abstract     = {Hepatocellular adenoma is a benign tumor of the liver that has a small but not negligible risk of malignant transformation into hepatocellular carcinoma. In analogy with the established role of oval cells in hepatocarcinogenesis in rodent models, human hepatic progenitor cells may have a function in the development of liver tumors. To investigate this issue, we performed immunohistochemistry on biopsies of 10 consecutively resected hepatocellular adenomas using mark ers for hepatic progenitor cells. Sections of paraffin-embedded and frozen biopsies were stained using antibodies against cytokeratins 7, 8, 18, and 19, chromogranin-A, OV-6, and neural cell adhesion molecule. Hepatic progenitor cells were observed in five of 10 hepatocellular adenomas. These five tumors also contained cells with an immunohistochemical phenotype intermediate be tween hepatic progenitor cells and hepatocytes. Hepatic progenitor cells and intermediate hepatocyte-like cells were scattered throughout the tumors with a density that varied from area to area. Ultrastructural examination confirmed the presence of hepatic progenitor cells. Our study shows that hepatic progenitor cells are present in a considerable proportion of hepatocellular adenomas, supporting the hypothesis that human hepatic progenitor cells can play a role in the development of heptocellular tumors.},
  author       = {Libbrecht, Louis and De Vos, Rita and Cassiman, David and Desmet, Valeer and Aerts, Raymond and Roskams, Tania},
  issn         = {0147-5185},
  journal      = {AMERICAN JOURNAL OF SURGICAL PATHOLOGY},
  keywords     = {hepatic progenitor cell,hepatocellular adenoma,oval cell,liver tumor development,immunohistochemistry,FOCAL NODULAR HYPERPLASIA,STEM-CELLS,RAT-LIVER,OVAL CELL,ORAL-CONTRACEPTIVES,DUCTULAR REACTION,EPITHELIAL-CELLS,EXPRESSION,CARCINOMA,DIFFERENTIATION},
  language     = {eng},
  number       = {11},
  pages        = {1388--1396},
  title        = {Hepatic progenitor cells in hepatocellular adenomas},
  url          = {http://dx.doi.org/10.1097/00000478-200111000-00006},
  volume       = {25},
  year         = {2001},
}

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