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Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases

(2001) HISTOCHEMISTRY AND CELL BIOLOGY. 116(3). p.233-239
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Abstract
In the liver, neural cell adhesion molecule (NCAM) is a marker of immature cells committed to the biliary lineage and is expressed by reactive bile ductules in human liver diseases. We investigated the possible role of NCAM in the development of intrahepatic bile ducts and aimed at determining whether immature biliary cells can contribute to the repair of damaged bile ducts in chronic liver diseases. Therefore, we performed immunohistochemistry for NCAM and bile duct cell markers cytokeratin 7 and cytokeratin 19 on frozen sections of 85 liver specimens taken from 14 fetuses, 10 donor livers, 18 patients with congenital liver diseases characterized by ductal plate malformations (DPMs), and 43 cirrhotic explant livers. Duplicated ductal plates and incorporating, bile ducts during development showed a patchy immunoreactivity for NCAM, while DPMs were continuously positive for NCAM. Bile ducts showing complete or patchy immunoreactivity for NCA M were found in cirrhotic livers, with higher frequency in biliary than in posthepatitic cirrhosis. Our results suggest that NCAM may have a function in the development of the intrahepatic bile ducts and that NCAM-positive immature biliary cells can contribute to the repair of damaged bile ducts in chronic liver diseases.
Keywords
liver cirrhosis, liver development, neural cell adhesion molecule, bile duct, ductal plate malformation, INTRAHEPATIC BILE-DUCTS, HEPATIC STELLATE CELLS, RAT-LIVER, N-CAM, PROGENITOR CELLS, BILIARY ATRESIA, NCAM, CHOLANGIOCYTES, INNERVATION, PLASTICITY

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MLA
Libbrecht, Louis, David Cassiman, Valeer Desmet, et al. “Expression of Neural Cell Adhesion Molecule in Human Liver Development and in Congenital and Acquired Liver Diseases.” HISTOCHEMISTRY AND CELL BIOLOGY 116.3 (2001): 233–239. Print.
APA
Libbrecht, L., Cassiman, D., Desmet, V., & Roskams, T. (2001). Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases. HISTOCHEMISTRY AND CELL BIOLOGY, 116(3), 233–239.
Chicago author-date
Libbrecht, Louis, David Cassiman, Valeer Desmet, and Tania Roskams. 2001. “Expression of Neural Cell Adhesion Molecule in Human Liver Development and in Congenital and Acquired Liver Diseases.” Histochemistry and Cell Biology 116 (3): 233–239.
Chicago author-date (all authors)
Libbrecht, Louis, David Cassiman, Valeer Desmet, and Tania Roskams. 2001. “Expression of Neural Cell Adhesion Molecule in Human Liver Development and in Congenital and Acquired Liver Diseases.” Histochemistry and Cell Biology 116 (3): 233–239.
Vancouver
1.
Libbrecht L, Cassiman D, Desmet V, Roskams T. Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases. HISTOCHEMISTRY AND CELL BIOLOGY. 2001;116(3):233–9.
IEEE
[1]
L. Libbrecht, D. Cassiman, V. Desmet, and T. Roskams, “Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases,” HISTOCHEMISTRY AND CELL BIOLOGY, vol. 116, no. 3, pp. 233–239, 2001.
@article{3183181,
  abstract     = {In the liver, neural cell adhesion molecule (NCAM) is a marker of immature cells committed to the biliary lineage and is expressed by reactive bile ductules in human liver diseases. We investigated the possible role of NCAM in the development of intrahepatic bile ducts and aimed at determining whether immature biliary cells can contribute to the repair of damaged bile ducts in chronic liver diseases. Therefore, we performed immunohistochemistry for NCAM and bile duct cell markers cytokeratin 7 and cytokeratin 19 on frozen sections of 85 liver specimens taken from 14 fetuses, 10 donor livers, 18 patients with congenital liver diseases characterized by ductal plate malformations (DPMs), and 43 cirrhotic explant livers. Duplicated ductal plates and incorporating, bile ducts during development showed a patchy immunoreactivity for NCAM, while DPMs were continuously positive for NCAM. Bile ducts showing complete or patchy immunoreactivity for NCA M were found in cirrhotic livers, with higher frequency in biliary than in posthepatitic cirrhosis. Our results suggest that NCAM may have a function in the development of the intrahepatic bile ducts and that NCAM-positive immature biliary cells can contribute to the repair of damaged bile ducts in chronic liver diseases.},
  author       = {Libbrecht, Louis and Cassiman, David and Desmet, Valeer and Roskams, Tania},
  issn         = {0948-6143},
  journal      = {HISTOCHEMISTRY AND CELL BIOLOGY},
  keywords     = {liver cirrhosis,liver development,neural cell adhesion molecule,bile duct,ductal plate malformation,INTRAHEPATIC BILE-DUCTS,HEPATIC STELLATE CELLS,RAT-LIVER,N-CAM,PROGENITOR CELLS,BILIARY ATRESIA,NCAM,CHOLANGIOCYTES,INNERVATION,PLASTICITY},
  language     = {eng},
  number       = {3},
  pages        = {233--239},
  title        = {Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases},
  url          = {http://dx.doi.org/10.1007/s004180100310},
  volume       = {116},
  year         = {2001},
}

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