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Noninvasive determination of local pulse wave velocity and wave intensity: changes with age and gender in the carotid and femoral arteries of healthy human

(2012) JOURNAL OF APPLIED PHYSIOLOGY. 113(5). p.727-735
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Abstract
We recently introduced noninvasive methods to assess local pulse wave velocity (PWV) and wave intensity ((n)dI) in arteries based on measurements of flow velocity (U) and diameter (D). Although the methods were validated in an experimental setting, clinical application remains lacking. The aim of this study was therefore to investigate the effect of age and gender on PWV and (n)dI in the carotid and femoral arteries of an existing population. We measured D and U in the carotid and femoral arteries of 1,774 healthy subjects aged 35-55 yr, a subgroup of the Asklepios population. With the use of the lnDU-loop method, we calculated local PWV, which was used to determine arterial distensibility (nDs). We then used the new algorithm to determine maximum forward and backward wave intensities ((n)dI(+max) and (n)dI(-min), respectively) and the reflection index (nRI). On average, PWV was higher, and nDs was lower in the femoral than at the carotid arteries. At the carotid artery, PWV increased with age, but nDs, (n)dI(+max), and (n)dI(-min) decreased; nRI did not change with age. At the femoral artery, PWV was higher, and nDs was lower in male, but all parameters did not change significantly with age in both women and men. We conclude that the carotid artery is more affected by the aging process than the femoral artery, even in healthy subjects. The new techniques provide mechanical and hemodynamic parameters, requiring only D and U measurements, both of which can be acquired using ultrasound equipment widely available today, hence their advantage for potential use in the clinical setting.
Keywords
distensibility, wave speed, wave separation, diameter, reflection index, BLOOD-PRESSURE, INDEPENDENT PREDICTOR, HYPERTENSIVE PATIENTS, CARDIOVASCULAR RISK, AORTIC STIFFNESS, SPEED, DIAMETER, REPRODUCIBILITY, SEPARATION, PULMONARY

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Citation

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MLA
Borlotti, Alessandra, Ashraf W Khir, Ernst Rietzschel, et al. “Noninvasive Determination of Local Pulse Wave Velocity and Wave Intensity: Changes with Age and Gender in the Carotid and Femoral Arteries of Healthy Human.” JOURNAL OF APPLIED PHYSIOLOGY 113.5 (2012): 727–735. Print.
APA
Borlotti, A., Khir, A. W., Rietzschel, E., De Buyzere, M., VERMEERSCH, S., & Segers, P. (2012). Noninvasive determination of local pulse wave velocity and wave intensity: changes with age and gender in the carotid and femoral arteries of healthy human. JOURNAL OF APPLIED PHYSIOLOGY, 113(5), 727–735.
Chicago author-date
Borlotti, Alessandra, Ashraf W Khir, Ernst Rietzschel, Marc De Buyzere, SEBASTIAN VERMEERSCH, and Patrick Segers. 2012. “Noninvasive Determination of Local Pulse Wave Velocity and Wave Intensity: Changes with Age and Gender in the Carotid and Femoral Arteries of Healthy Human.” Journal of Applied Physiology 113 (5): 727–735.
Chicago author-date (all authors)
Borlotti, Alessandra, Ashraf W Khir, Ernst Rietzschel, Marc De Buyzere, SEBASTIAN VERMEERSCH, and Patrick Segers. 2012. “Noninvasive Determination of Local Pulse Wave Velocity and Wave Intensity: Changes with Age and Gender in the Carotid and Femoral Arteries of Healthy Human.” Journal of Applied Physiology 113 (5): 727–735.
Vancouver
1.
Borlotti A, Khir AW, Rietzschel E, De Buyzere M, VERMEERSCH S, Segers P. Noninvasive determination of local pulse wave velocity and wave intensity: changes with age and gender in the carotid and femoral arteries of healthy human. JOURNAL OF APPLIED PHYSIOLOGY. 2012;113(5):727–35.
IEEE
[1]
A. Borlotti, A. W. Khir, E. Rietzschel, M. De Buyzere, S. VERMEERSCH, and P. Segers, “Noninvasive determination of local pulse wave velocity and wave intensity: changes with age and gender in the carotid and femoral arteries of healthy human,” JOURNAL OF APPLIED PHYSIOLOGY, vol. 113, no. 5, pp. 727–735, 2012.
@article{3180473,
  abstract     = {We recently introduced noninvasive methods to assess local pulse wave velocity (PWV) and wave intensity ((n)dI) in arteries based on measurements of flow velocity (U) and diameter (D). Although the methods were validated in an experimental setting, clinical application remains lacking. The aim of this study was therefore to investigate the effect of age and gender on PWV and (n)dI in the carotid and femoral arteries of an existing population. We measured D and U in the carotid and femoral arteries of 1,774 healthy subjects aged 35-55 yr, a subgroup of the Asklepios population. With the use of the lnDU-loop method, we calculated local PWV, which was used to determine arterial distensibility (nDs). We then used the new algorithm to determine maximum forward and backward wave intensities ((n)dI(+max) and (n)dI(-min), respectively) and the reflection index (nRI). On average, PWV was higher, and nDs was lower in the femoral than at the carotid arteries. At the carotid artery, PWV increased with age, but nDs, (n)dI(+max), and (n)dI(-min) decreased; nRI did not change with age. At the femoral artery, PWV was higher, and nDs was lower in male, but all parameters did not change significantly with age in both women and men. We conclude that the carotid artery is more affected by the aging process than the femoral artery, even in healthy subjects. The new techniques provide mechanical and hemodynamic parameters, requiring only D and U measurements, both of which can be acquired using ultrasound equipment widely available today, hence their advantage for potential use in the clinical setting.},
  author       = {Borlotti, Alessandra and Khir, Ashraf W and Rietzschel, Ernst and De Buyzere, Marc and VERMEERSCH, SEBASTIAN and Segers, Patrick},
  issn         = {8750-7587},
  journal      = {JOURNAL OF APPLIED PHYSIOLOGY},
  keywords     = {distensibility,wave speed,wave separation,diameter,reflection index,BLOOD-PRESSURE,INDEPENDENT PREDICTOR,HYPERTENSIVE PATIENTS,CARDIOVASCULAR RISK,AORTIC STIFFNESS,SPEED,DIAMETER,REPRODUCIBILITY,SEPARATION,PULMONARY},
  language     = {eng},
  number       = {5},
  pages        = {727--735},
  title        = {Noninvasive determination of local pulse wave velocity and wave intensity: changes with age and gender in the carotid and femoral arteries of healthy human},
  url          = {http://dx.doi.org/10.1152/japplphysiol.00164.2012},
  volume       = {113},
  year         = {2012},
}

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