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Delta-protocadherins in health and disease

Irene Kahr UGent, Karl Vandepoele and Frans Van Roy UGent (2013) Progress in Molecular Biology and Translational Science. 116. p.169-192
abstract
The protocadherin family comprises clustered and nonclustered protocadherin genes. The nonclustered genes encode mainly d-protocadherins, which deviate markedly from classical cadherins. They can be subdivided phylogenetically into d0-protocadherins (protocadherin-20), d1-protocadherins (protocadherin-1, -7, -9, and -11X/Y), and d2-protocadherins (protocadherin-8, -10, -17, -18, and -19). d-Protocadherins share a similar gene structure and are expressed as multiple alternative splice forms differing mostly in their cytoplasmic domains (CDs). Some d-protocadherins reportedly show cell–cell adhesion properties. Individual d-protocadherins appear to be involved in specific signaling pathways, as they interact with proteins such as TAF1/Set, TAO2b, Nap1, and the Frizzled-7 receptor. The spatiotemporally restricted expression of d-protocadherins in various tissues and species and their functional analysis suggest that they play multiple, tightly regulated roles in vertebrate development. Furthermore, several d-protocadherins have been implicated in neurological disorders and in cancers, highlighting the importance of scrutinizing their properties and their dysregulation in various pathologies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
XENOPUS PARAXIAL PROTOCADHERIN, GENOME-WIDE ANALYSIS, CANDIDATE TUMOR-SUPPRESSOR, ONSET ALZHEIMERS-DISEASE, SQUAMOUS-CELL CARCINOMA, PROSTATE-CANCER CELLS, NF-PROTOCADHERIN, GENE-EXPRESSION, PROMOTER METHYLATION, CADHERIN SUPERFAMILY
journal title
Progress in Molecular Biology and Translational Science
Prog. Molec. Biol. Transl. Sci.
editor
Frans Van Roy UGent
volume
116
issue title
The molecular biology of cadherins
pages
169 - 192
publisher
Academic Press
place of publication
Oxford, UK
Web of Science type
Review; Book Chapter
Web of Science id
000318528500009
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
3.111 (2013)
JCR rank
123/291 (2013)
JCR quartile
2 (2013)
ISSN
1877-1173
ISBN
9780123943118
DOI
10.1016/B978-0-12-394311-8.00008-X
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3164287
handle
http://hdl.handle.net/1854/LU-3164287
date created
2013-03-13 15:05:07
date last changed
2017-01-02 09:53:35
@article{3164287,
  abstract     = {The protocadherin family comprises clustered and nonclustered protocadherin genes. The nonclustered genes encode mainly d-protocadherins, which deviate markedly from classical cadherins. They can be subdivided phylogenetically into d0-protocadherins (protocadherin-20), d1-protocadherins (protocadherin-1, -7, -9, and -11X/Y), and d2-protocadherins (protocadherin-8, -10, -17, -18, and -19). d-Protocadherins share a similar gene structure and are expressed as multiple alternative splice forms differing mostly in their cytoplasmic domains (CDs). Some d-protocadherins reportedly show cell--cell adhesion properties. Individual d-protocadherins appear to be involved in specific signaling pathways, as they interact with proteins such as TAF1/Set, TAO2b, Nap1, and the Frizzled-7 receptor. The spatiotemporally restricted expression of d-protocadherins in various tissues and species and their functional analysis suggest that they play multiple, tightly regulated roles in vertebrate development. Furthermore, several d-protocadherins have been implicated in neurological disorders and in cancers, highlighting the importance of scrutinizing their properties and their dysregulation in various pathologies.},
  author       = {Kahr, Irene and Vandepoele, Karl and Van Roy, Frans},
  editor       = {Van Roy, Frans},
  isbn         = {9780123943118},
  issn         = {1877-1173},
  journal      = {Progress in Molecular Biology and Translational Science},
  keyword      = {XENOPUS PARAXIAL PROTOCADHERIN,GENOME-WIDE ANALYSIS,CANDIDATE TUMOR-SUPPRESSOR,ONSET ALZHEIMERS-DISEASE,SQUAMOUS-CELL CARCINOMA,PROSTATE-CANCER CELLS,NF-PROTOCADHERIN,GENE-EXPRESSION,PROMOTER METHYLATION,CADHERIN SUPERFAMILY},
  language     = {eng},
  pages        = {169--192},
  publisher    = {Academic Press},
  title        = {Delta-protocadherins in health and disease},
  url          = {http://dx.doi.org/10.1016/B978-0-12-394311-8.00008-X},
  volume       = {116},
  year         = {2013},
}

Chicago
Kahr, Irene, KARL VANDEPOELE, and Frans Van Roy. 2013. “Delta-protocadherins in Health and Disease.” Ed. Frans Van Roy. Progress in Molecular Biology and Translational Science 116: 169–192.
APA
Kahr, I., VANDEPOELE, K., & Van Roy, F. (2013). Delta-protocadherins in health and disease. (Frans Van Roy, Ed.)Progress in Molecular Biology and Translational Science, 116, 169–192.
Vancouver
1.
Kahr I, VANDEPOELE K, Van Roy F. Delta-protocadherins in health and disease. Van Roy F, editor. Progress in Molecular Biology and Translational Science. Oxford, UK: Academic Press; 2013;116:169–92.
MLA
Kahr, Irene, KARL VANDEPOELE, and Frans Van Roy. “Delta-protocadherins in Health and Disease.” Ed. Frans Van Roy. Progress in Molecular Biology and Translational Science 116 (2013): 169–192. Print.