Advanced search
1 file | 1.12 MB

Delta-protocadherins in health and disease

Irene Kahr (UGent) , Karl Vandepoele (UGent) and Frans Van Roy (UGent)
Author
Organization
Abstract
The protocadherin family comprises clustered and nonclustered protocadherin genes. The nonclustered genes encode mainly d-protocadherins, which deviate markedly from classical cadherins. They can be subdivided phylogenetically into d0-protocadherins (protocadherin-20), d1-protocadherins (protocadherin-1, -7, -9, and -11X/Y), and d2-protocadherins (protocadherin-8, -10, -17, -18, and -19). d-Protocadherins share a similar gene structure and are expressed as multiple alternative splice forms differing mostly in their cytoplasmic domains (CDs). Some d-protocadherins reportedly show cell–cell adhesion properties. Individual d-protocadherins appear to be involved in specific signaling pathways, as they interact with proteins such as TAF1/Set, TAO2b, Nap1, and the Frizzled-7 receptor. The spatiotemporally restricted expression of d-protocadherins in various tissues and species and their functional analysis suggest that they play multiple, tightly regulated roles in vertebrate development. Furthermore, several d-protocadherins have been implicated in neurological disorders and in cancers, highlighting the importance of scrutinizing their properties and their dysregulation in various pathologies.
Keywords
XENOPUS PARAXIAL PROTOCADHERIN, GENOME-WIDE ANALYSIS, CANDIDATE TUMOR-SUPPRESSOR, ONSET ALZHEIMERS-DISEASE, SQUAMOUS-CELL CARCINOMA, PROSTATE-CANCER CELLS, NF-PROTOCADHERIN, GENE-EXPRESSION, PROMOTER METHYLATION, CADHERIN SUPERFAMILY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.12 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Kahr, Irene, Karl Vandepoele, and Frans Van Roy. 2013. “Delta-protocadherins in Health and Disease.” Ed. Frans Van Roy. Progress in Molecular Biology and Translational Science 116: 169–192.
APA
Kahr, I., Vandepoele, K., & Van Roy, F. (2013). Delta-protocadherins in health and disease. (Frans Van Roy, Ed.)Progress in Molecular Biology and Translational Science, 116, 169–192.
Vancouver
1.
Kahr I, Vandepoele K, Van Roy F. Delta-protocadherins in health and disease. Van Roy F, editor. Progress in Molecular Biology and Translational Science. Oxford, UK: Academic Press; 2013;116:169–92.
MLA
Kahr, Irene, Karl Vandepoele, and Frans Van Roy. “Delta-protocadherins in Health and Disease.” Ed. Frans Van Roy. Progress in Molecular Biology and Translational Science 116 (2013): 169–192. Print.
@article{3164287,
  abstract     = {The protocadherin family comprises clustered and nonclustered protocadherin genes. The nonclustered genes encode mainly d-protocadherins, which deviate markedly from classical cadherins. They can be subdivided phylogenetically into d0-protocadherins (protocadherin-20), d1-protocadherins (protocadherin-1, -7, -9, and -11X/Y), and d2-protocadherins (protocadherin-8, -10, -17, -18, and -19). d-Protocadherins share a similar gene structure and are expressed as multiple alternative splice forms differing mostly in their cytoplasmic domains (CDs). Some d-protocadherins reportedly show cell--cell adhesion properties. Individual d-protocadherins appear to be involved in specific signaling pathways, as they interact with proteins such as TAF1/Set, TAO2b, Nap1, and the Frizzled-7 receptor. The spatiotemporally restricted expression of d-protocadherins in various tissues and species and their functional analysis suggest that they play multiple, tightly regulated roles in vertebrate development. Furthermore, several d-protocadherins have been implicated in neurological disorders and in cancers, highlighting the importance of scrutinizing their properties and their dysregulation in various pathologies.},
  author       = {Kahr, Irene and Vandepoele, Karl and Van Roy, Frans},
  editor       = {Van Roy, Frans},
  isbn         = {9780123943118},
  issn         = {1877-1173},
  journal      = {Progress in Molecular Biology and Translational Science},
  keyword      = {XENOPUS PARAXIAL PROTOCADHERIN,GENOME-WIDE ANALYSIS,CANDIDATE TUMOR-SUPPRESSOR,ONSET ALZHEIMERS-DISEASE,SQUAMOUS-CELL CARCINOMA,PROSTATE-CANCER CELLS,NF-PROTOCADHERIN,GENE-EXPRESSION,PROMOTER METHYLATION,CADHERIN SUPERFAMILY},
  language     = {eng},
  pages        = {169--192},
  publisher    = {Academic Press},
  title        = {Delta-protocadherins in health and disease},
  url          = {http://dx.doi.org/10.1016/B978-0-12-394311-8.00008-X},
  volume       = {116},
  year         = {2013},
}

Altmetric
View in Altmetric
Web of Science
Times cited: