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New insights into the evolution of metazoan cadherins and catenins

Paco Hulpiau (UGent) , Ismail Sahin Gül (UGent) and Frans Van Roy (UGent)
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Abstract
E-Cadherin and b-catenin are the best studied representatives of the superfamilies of transmembrane cadherins and intracellular armadillo catenins, respectively. However, in over 600 million years of multicellular animal evolution, these two superfamilies have diversified remarkably both structurally and functionally. Although their basic building blocks, respectively, the cadherin repeat domain and the armadillo repeat domain, predate metazoans, the specific and complex domain compositions of the different family members and their functional roles in cell adhesion and signaling appear to be key features for the emergence of multicellular animal life. Basal animals such as placozoans and sponges have a limited number of distinct cadherins and catenins. The origin of vertebrates, in particular, coincided with a large increase in the number of cadherins and armadillo proteins, including modern “classical” cadherins, protocadherins, and plakophilins. Also, a-catenins increased. This chapter introduces the many different family members and describes the putative evolutionary relationships between them.
Keywords
CELL-CELL ADHESION, ARMADILLO-REPEAT PROTEINS, ALPHA-T-CATENIN, BETA-CATENIN, ADHERENS JUNCTIONS, SIGNALING PATHWAY, CLASSIC CADHERINS, CRYSTAL-STRUCTURE, GENE, FAMILY

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Citation

Please use this url to cite or link to this publication:

Chicago
Hulpiau, Paco, Ismail Sahin Gül, and Frans Van Roy. 2013. “New Insights into the Evolution of Metazoan Cadherins and Catenins.” Ed. Frans Van Roy. Progress in Molecular Biology and Translational Science 116: 71–94.
APA
Hulpiau, P., Gül, I. S., & Van Roy, F. (2013). New insights into the evolution of metazoan cadherins and catenins. (Frans Van Roy, Ed.)Progress in Molecular Biology and Translational Science, 116, 71–94.
Vancouver
1.
Hulpiau P, Gül IS, Van Roy F. New insights into the evolution of metazoan cadherins and catenins. Van Roy F, editor. Progress in Molecular Biology and Translational Science. Oxford, UK: Academic Press; 2013;116:71–94.
MLA
Hulpiau, Paco, Ismail Sahin Gül, and Frans Van Roy. “New Insights into the Evolution of Metazoan Cadherins and Catenins.” Ed. Frans Van Roy. Progress in Molecular Biology and Translational Science 116 (2013): 71–94. Print.
@article{3164279,
  abstract     = {E-Cadherin and b-catenin are the best studied representatives of the superfamilies of transmembrane cadherins and intracellular armadillo catenins, respectively. However, in over 600 million years of multicellular animal evolution, these two superfamilies have diversified remarkably both structurally and functionally. Although their basic building blocks, respectively, the cadherin repeat domain and the armadillo repeat domain, predate metazoans, the specific and complex domain compositions of the different family members and their functional roles in cell adhesion and signaling appear to be key features for the emergence of multicellular animal life. Basal animals such as placozoans and sponges have a limited number of distinct cadherins and catenins. The origin of vertebrates, in particular, coincided with a large increase in the number of cadherins and armadillo proteins, including modern “classical” cadherins, protocadherins, and plakophilins. Also, a-catenins increased. This chapter introduces the many different family members and describes the putative evolutionary relationships between them.},
  author       = {Hulpiau, Paco and Gül, Ismail Sahin and Van Roy, Frans},
  editor       = {Van Roy, Frans},
  isbn         = {9780123943118},
  issn         = {1877-1173},
  journal      = {Progress in Molecular Biology and Translational Science},
  keywords     = {CELL-CELL ADHESION,ARMADILLO-REPEAT PROTEINS,ALPHA-T-CATENIN,BETA-CATENIN,ADHERENS JUNCTIONS,SIGNALING PATHWAY,CLASSIC CADHERINS,CRYSTAL-STRUCTURE,GENE,FAMILY},
  language     = {eng},
  pages        = {71--94},
  publisher    = {Academic Press},
  title        = {New insights into the evolution of metazoan cadherins and catenins},
  url          = {http://dx.doi.org/10.1016/B978-0-12-394311-8.00004-2},
  volume       = {116},
  year         = {2013},
}

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