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PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction

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Abstract
Deterioration of left ventricular (LV) function after myocardial infarction (MI) is a major cause of heart failure. Myocardial perfusion performance may play an important role in deterioration or improvement in LV function after MI. The aim of this study was to evaluate the myocardial perfusion reserve (MPR) and stress perfusion in deteriorating and non-deteriorating LV segments in patients after MI by PET and MRI, respectively. Regional wall thickening of 352 segments in 22 patients was assessed at 4 and 24 months after MI by cardiac MRI. PET was performed to evaluate MPR and adenosine stress N-13-ammonia perfusion 24 months after MI. Segments were divided into four groups according to deterioration or improvement in wall thickening. Normal functional segments at 4 months after MI that remained stable had a significantly higher mean MPR and mean stress perfusion PET value than deteriorated segments (p < 0.001). Furthermore, dysfunctional segments that improved had a significantly higher mean stress perfusion PET value than dysfunctional segments that remained dysfunctional (p < 0.001). This study demonstrated the additional value of myocardial perfusion assessment in relation to the functional integrity of the injured myocardium. Segmental functional LV improvement after MI was associated with better regional myocardial perfusion characteristics. Furthermore, the amount of wall thickening reduction was associated with regional myocardial perfusion abnormalities in patients after MI.
Keywords
Cardiac MRI, CORONARY MICROVASCULAR DYSFUNCTION, Myocardial perfusion imaging, Left ventricular function, Myocardial infarction, IDIOPATHIC DILATED CARDIOMYOPATHY, GENE-THERAPY, BONE-MARROW, RESERVE, APOPTOSIS, DISEASE

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Chicago
Slart, Riemer HJA, Julius Glauche, Reza Golestani, Clark J Zeebregts, Jan W Jansen, Rudi Dierckx, Matthijs Oudkerk, et al. 2012. “PET and MRI for the Evaluation of Regional Myocardial Perfusion and Wall Thickening After Myocardial Infarction.” European Journal of Nuclear Medicine and Molecular Imaging 39 (6): 1065–1069.
APA
Slart, R. H., Glauche, J., Golestani, R., Zeebregts, C. J., Jansen, J. W., Dierckx, R., Oudkerk, M., et al. (2012). PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 39(6), 1065–1069.
Vancouver
1.
Slart RH, Glauche J, Golestani R, Zeebregts CJ, Jansen JW, Dierckx R, et al. PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2012;39(6):1065–9.
MLA
Slart, Riemer HJA, Julius Glauche, Reza Golestani, et al. “PET and MRI for the Evaluation of Regional Myocardial Perfusion and Wall Thickening After Myocardial Infarction.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 39.6 (2012): 1065–1069. Print.
@article{3151201,
  abstract     = {Deterioration of left ventricular (LV) function after myocardial infarction (MI) is a major cause of heart failure. Myocardial perfusion performance may play an important role in deterioration or improvement in LV function after MI. The aim of this study was to evaluate the myocardial perfusion reserve (MPR) and stress perfusion in deteriorating and non-deteriorating LV segments in patients after MI by PET and MRI, respectively.
Regional wall thickening of 352 segments in 22 patients was assessed at 4 and 24 months after MI by cardiac MRI. PET was performed to evaluate MPR and adenosine stress N-13-ammonia perfusion 24 months after MI. Segments were divided into four groups according to deterioration or improvement in wall thickening.
Normal functional segments at 4 months after MI that remained stable had a significantly higher mean MPR and mean stress perfusion PET value than deteriorated segments (p {\textlangle} 0.001). Furthermore, dysfunctional segments that improved had a significantly higher mean stress perfusion PET value than dysfunctional segments that remained dysfunctional (p {\textlangle} 0.001).
This study demonstrated the additional value of myocardial perfusion assessment in relation to the functional integrity of the injured myocardium. Segmental functional LV improvement after MI was associated with better regional myocardial perfusion characteristics. Furthermore, the amount of wall thickening reduction was associated with regional myocardial perfusion abnormalities in patients after MI.},
  author       = {Slart, Riemer HJA and Glauche, Julius and Golestani, Reza and Zeebregts, Clark J and Jansen, Jan W and Dierckx, Rudi and Oudkerk, Matthijs and Willems, Tineke P and Glaudemans, Andor WJM and Boersma, Hendrikus H and Tio, Ren{\'e} A},
  issn         = {1619-7070},
  journal      = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
  keyword      = {Cardiac MRI,CORONARY MICROVASCULAR DYSFUNCTION,Myocardial perfusion imaging,Left ventricular function,Myocardial infarction,IDIOPATHIC DILATED CARDIOMYOPATHY,GENE-THERAPY,BONE-MARROW,RESERVE,APOPTOSIS,DISEASE},
  language     = {eng},
  number       = {6},
  pages        = {1065--1069},
  title        = {PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction},
  url          = {http://dx.doi.org/10.1007/s00259-012-2085-0},
  volume       = {39},
  year         = {2012},
}

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