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Imaging of β-cell mass and insulitis in insulin-dependent (type 1) diabetes mellitus

(2012) ENDOCRINE REVIEWS. 33(6). p.892-919
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Abstract
Insulin-dependent (type 1) diabetes mellitus is a metabolic disease with a complex multifactorial etiology and a poorly understood pathogenesis. Genetic and environmental factors cause an autoimmune reaction against pancreatic beta-cells, called insulitis, confirmed in pancreatic samples obtained at autopsy. The possibility to noninvasively quantify beta-cell mass in vivo would provide important biological insights and facilitate aspects of diagnosis and therapy, including follow-up of islet cell transplantation. Moreover, the availability of a noninvasive tool to quantify the extent and severity of pancreatic insulitis could be useful for understanding the natural history of human insulin-dependent(type 1) diabetes mellitus, to early diagnose children at risk to develop overt diabetes, and to select patients to be treated with immunotherapies aimed at blocking the insulitis and monitoring the efficacy of these therapies. In this review, we outline the imaging techniques currently available for in vivo, noninvasive detection of beta-cell mass and insulitis. These imaging techniques include magnetic resonance imaging, ultrasound, computed tomography, bioluminescence and fluorescence imaging, and the nuclear medicine techniques positron emission tomography and single-photon emission computed tomography. Several approaches and radiopharmaceuticals for imaging beta-cells and lymphocytic insulitis are reviewed in detail.
Keywords
GLIBENCLAMIDE BINDING, REAL-TIME, NOD MOUSE, ISLET TRANSPLANTATION, PARKINSONS-DISEASE, IN-VIVO MEASUREMENT, GLUCAGON-LIKE PEPTIDES, PANCREATIC ENDOCRINE TUMORS, POSITRON-EMISSION-TOMOGRAPHY, VESICULAR MONOAMINE TRANSPORTER

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Chicago
Di Gialleonardo, Valentina, Erik FJ de Vries, Marco Di Girolamo, Ana M Quintero, Rudi Dierckx, and Alberto Signore. 2012. “Imaging of Β-cell Mass and Insulitis in Insulin-dependent (type 1) Diabetes Mellitus.” Endocrine Reviews 33 (6): 892–919.
APA
Di Gialleonardo, Valentina, de Vries, E. F., Di Girolamo, M., Quintero, A. M., Dierckx, R., & Signore, A. (2012). Imaging of β-cell mass and insulitis in insulin-dependent (type 1) diabetes mellitus. ENDOCRINE REVIEWS, 33(6), 892–919.
Vancouver
1.
Di Gialleonardo V, de Vries EF, Di Girolamo M, Quintero AM, Dierckx R, Signore A. Imaging of β-cell mass and insulitis in insulin-dependent (type 1) diabetes mellitus. ENDOCRINE REVIEWS. 2012;33(6):892–919.
MLA
Di Gialleonardo, Valentina, Erik FJ de Vries, Marco Di Girolamo, et al. “Imaging of Β-cell Mass and Insulitis in Insulin-dependent (type 1) Diabetes Mellitus.” ENDOCRINE REVIEWS 33.6 (2012): 892–919. Print.
@article{3150597,
  abstract     = {Insulin-dependent (type 1) diabetes mellitus is a metabolic disease with a complex multifactorial etiology and a poorly understood pathogenesis. Genetic and environmental factors cause an autoimmune reaction against pancreatic beta-cells, called insulitis, confirmed in pancreatic samples obtained at autopsy. The possibility to noninvasively quantify beta-cell mass in vivo would provide important biological insights and facilitate aspects of diagnosis and therapy, including follow-up of islet cell transplantation. Moreover, the availability of a noninvasive tool to quantify the extent and severity of pancreatic insulitis could be useful for understanding the natural history of human insulin-dependent(type 1) diabetes mellitus, to early diagnose children at risk to develop overt diabetes, and to select patients to be treated with immunotherapies aimed at blocking the insulitis and monitoring the efficacy of these therapies. In this review, we outline the imaging techniques currently available for in vivo, noninvasive detection of beta-cell mass and insulitis. These imaging techniques include magnetic resonance imaging, ultrasound, computed tomography, bioluminescence and fluorescence imaging, and the nuclear medicine techniques positron emission tomography and single-photon emission computed tomography. Several approaches and radiopharmaceuticals for imaging beta-cells and lymphocytic insulitis are reviewed in detail.},
  author       = {Di Gialleonardo, Valentina and de Vries, Erik FJ and Di Girolamo, Marco and Quintero, Ana M and Dierckx, Rudi and Signore, Alberto},
  issn         = {0163-769X},
  journal      = {ENDOCRINE REVIEWS},
  language     = {eng},
  number       = {6},
  pages        = {892--919},
  title        = {Imaging of \ensuremath{\beta}-cell mass and insulitis in insulin-dependent (type 1) diabetes mellitus},
  url          = {http://dx.doi.org/10.1210/er.2011-1041},
  volume       = {33},
  year         = {2012},
}

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