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Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers : a double-blind, randomised, placebo-controlled, cross-over trial

(2012) BRITISH JOURNAL OF NUTRITION. 108(12). p.2229-2242
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Abstract
Wheat bran extract (WBE) is a food-grade soluble fibre preparation that is highly enriched in arabinoxylan oligosaccharides. In this placebo-controlled cross-over human intervention trial, tolerance and effects on colonic protein and carbohydrate fermentation were studied. After a 1-week run-in period, sixty-three healthy adult volunteers consumed 3, 10 and 0 g WBE/d for 3 weeks in a random order, with 2 weeks' washout between each treatment period. Fasting blood samples were collected at the end of the run-in period and at the end of each treatment period for analysis of haematological and clinical chemistry parameters. Additionally, subjects collected a stool sample for analysis of microbiota, SCFA and pH. A urine sample, collected over 48 h, was used for analysis of p-cresol and phenol content. Finally, the subjects completed questionnaires scoring occurrence frequency and distress severity of eighteen gastrointestinal symptoms. Urinary p-cresol excretion was significantly decreased after WBE consumption at 10 g/d. Faecal bifidobacteria levels were significantly increased after daily intake of 10 g WBE. Additionally, WBE intake at 10 g/d increased faecal SCFA concentrations and lowered faecal pH, indicating increased colonic fermentation of WBE into desired metabolites. At 10 g/d, WBE caused a mild increase in flatulence occurrence frequency and distress severity and a tendency for a mild decrease in constipation occurrence frequency. In conclusion, WBE is well tolerated at doses up to 10 g/d in healthy adults volunteers. Intake of 10 g WBE/d exerts beneficial effects on gut health parameters.
Keywords
Prebiotics, Wheat bran extract, Protein fermentation reduction, Colonic SCFA, p-Cresol, CHAIN FATTY-ACIDS, 16S RIBOSOMAL-RNA, IN-SITU HYBRIDIZATION, INTESTINAL MICROBIAL ECOSYSTEM, BUTYRATE-PRODUCING BACTERIA, RESISTANT STARCH, CHICORY INULIN, HUMAN GUT, FECAL BIFIDOBACTERIA, DIETARY INCLUSION

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Citation

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Chicago
Francois, Isabelle EJA, Olivier Lescroart, Wim S Veraverbeke, Massimo Marzorati, Sam Possemiers, Pieter Evenepoel, Henrike Hamer, et al. 2012. “Effects of a Wheat Bran Extract Containing Arabinoxylan Oligosaccharides on Gastrointestinal Health Parameters in Healthy Adult Human Volunteers : a Double-blind, Randomised, Placebo-controlled, Cross-over Trial.” British Journal of Nutrition 108 (12): 2229–2242.
APA
Francois, I. E., Lescroart, O., Veraverbeke, W. S., Marzorati, M., Possemiers, S., Evenepoel, P., Hamer, H., et al. (2012). Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers : a double-blind, randomised, placebo-controlled, cross-over trial. BRITISH JOURNAL OF NUTRITION, 108(12), 2229–2242.
Vancouver
1.
Francois IE, Lescroart O, Veraverbeke WS, Marzorati M, Possemiers S, Evenepoel P, et al. Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers : a double-blind, randomised, placebo-controlled, cross-over trial. BRITISH JOURNAL OF NUTRITION. 2012;108(12):2229–42.
MLA
Francois, Isabelle EJA, Olivier Lescroart, Wim S Veraverbeke, et al. “Effects of a Wheat Bran Extract Containing Arabinoxylan Oligosaccharides on Gastrointestinal Health Parameters in Healthy Adult Human Volunteers : a Double-blind, Randomised, Placebo-controlled, Cross-over Trial.” BRITISH JOURNAL OF NUTRITION 108.12 (2012): 2229–2242. Print.
@article{3140491,
  abstract     = {Wheat bran extract (WBE) is a food-grade soluble fibre preparation that is highly enriched in arabinoxylan oligosaccharides. In this placebo-controlled cross-over human intervention trial, tolerance and effects on colonic protein and carbohydrate fermentation were studied. After a 1-week run-in period, sixty-three healthy adult volunteers consumed 3, 10 and 0 g WBE/d for 3 weeks in a random order, with 2 weeks' washout between each treatment period. Fasting blood samples were collected at the end of the run-in period and at the end of each treatment period for analysis of haematological and clinical chemistry parameters. Additionally, subjects collected a stool sample for analysis of microbiota, SCFA and pH. A urine sample, collected over 48 h, was used for analysis of p-cresol and phenol content. Finally, the subjects completed questionnaires scoring occurrence frequency and distress severity of eighteen gastrointestinal symptoms. Urinary p-cresol excretion was significantly decreased after WBE consumption at 10 g/d. Faecal bifidobacteria levels were significantly increased after daily intake of 10 g WBE. Additionally, WBE intake at 10 g/d increased faecal SCFA concentrations and lowered faecal pH, indicating increased colonic fermentation of WBE into desired metabolites. At 10 g/d, WBE caused a mild increase in flatulence occurrence frequency and distress severity and a tendency for a mild decrease in constipation occurrence frequency. In conclusion, WBE is well tolerated at doses up to 10 g/d in healthy adults volunteers. Intake of 10 g WBE/d exerts beneficial effects on gut health parameters.},
  author       = {Francois, Isabelle EJA and Lescroart, Olivier and Veraverbeke, Wim S and Marzorati, Massimo and Possemiers, Sam and Evenepoel, Pieter and Hamer, Henrike and Houben, Els and Windey, Karen and Welling, Gjalt W and Delcour, Jan A and Courtin, Christophe M and Verbeke, Kristin and Broekaert, Willem F},
  issn         = {0007-1145},
  journal      = {BRITISH JOURNAL OF NUTRITION},
  language     = {eng},
  number       = {12},
  pages        = {2229--2242},
  title        = {Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers : a double-blind, randomised, placebo-controlled, cross-over trial},
  url          = {http://dx.doi.org/10.1017/S0007114512000372},
  volume       = {108},
  year         = {2012},
}

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