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Staphylococcus aureus enterotoxins in airway diseases

(2004) ALLERGOLOGIE. 27(8). p.323-332
Author
Organization
Abstract
Staphylococcus aureus is a frequent germ in the upper airways, and, under appropriate conditions, may produce enterotoxins with superantigenic activities. The classical enterotoxins SEA-E and TSST-l activate B- and T cells, eosinophils, epithelial and other cells, and are able to induce a polyclonal immune response including IgE synthesis and eosinophilic inflammation. We have shown that nasal polyps frequently are colonized with Staphylococcus aureus, inducing a local immune reaction, which aggravates the eosinophilic inflammatory response. IgE antibodies in nasal polyp tissue may be used as diagnostic means for this immune reaction. We consider it probable that enterotoxines from Staphylococcus aureus are crucially contributing to this often difficult to treat disease of the upper airways. Furthermore, recent studies in severe, steroid-dependent asthmatics have shown that IgE-antibodies to enterotoxins are also found in the sera of these patients and similar pathomechanisms as in polyps may apply for the lower airways. To summarize, enterotoxins from Staphylococcus aureus most probably play an at least modulating role in severe upper and lower airway disease.
Keywords
T-CELL-RECEPTOR, SHOCK SYNDROME TOXIN-1, ANTIGEN-PRESENTING CELLS, BLOOD MONONUCLEAR-CELLS, COMPLEX CLASS-I, ATOPIC-DERMATITIS, IMMUNE-RESPONSE, PROTEIN-A, MICROBIAL SUPERANTIGENS, EXFOLIATIVE TOXINS, Staphylococcus aureus, enterotoxins, nasal polyps, asthma, IgE, eosinophils

Citation

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Chicago
Van Zele, Thibaut, Rudy Gevaert, L De Schrijver, Paul Van Cauwenberge, and Claus Bachert. 2004. “Staphylococcus Aureus Enterotoxins in Airway Diseases.” Allergologie 27 (8): 323–332.
APA
Van Zele, T., Gevaert, R., De Schrijver, L., Van Cauwenberge, P., & Bachert, C. (2004). Staphylococcus aureus enterotoxins in airway diseases. ALLERGOLOGIE, 27(8), 323–332.
Vancouver
1.
Van Zele T, Gevaert R, De Schrijver L, Van Cauwenberge P, Bachert C. Staphylococcus aureus enterotoxins in airway diseases. ALLERGOLOGIE. 2004;27(8):323–32.
MLA
Van Zele, Thibaut, Rudy Gevaert, L De Schrijver, et al. “Staphylococcus Aureus Enterotoxins in Airway Diseases.” ALLERGOLOGIE 27.8 (2004): 323–332. Print.
@article{313683,
  abstract     = {Staphylococcus aureus is a frequent germ in the upper airways, and, under appropriate conditions, may produce enterotoxins with superantigenic activities. The classical enterotoxins SEA-E and TSST-l activate B- and T cells, eosinophils, epithelial and other cells, and are able to induce a polyclonal immune response including IgE synthesis and eosinophilic inflammation. We have shown that nasal polyps frequently are colonized with Staphylococcus aureus, inducing a local immune reaction, which aggravates the eosinophilic inflammatory response. IgE antibodies in nasal polyp tissue may be used as diagnostic means for this immune reaction. We consider it probable that enterotoxines from Staphylococcus aureus are crucially contributing to this often difficult to treat disease of the upper airways. Furthermore, recent studies in severe, steroid-dependent asthmatics have shown that IgE-antibodies to enterotoxins are also found in the sera of these patients and similar pathomechanisms as in polyps may apply for the lower airways. To summarize, enterotoxins from Staphylococcus aureus most probably play an at least modulating role in severe upper and lower airway disease.},
  author       = {Van Zele, Thibaut and Gevaert, Rudy and De Schrijver, L and Van Cauwenberge, Paul and Bachert, Claus},
  issn         = {0344-5062},
  journal      = {ALLERGOLOGIE},
  keywords     = {T-CELL-RECEPTOR,SHOCK SYNDROME TOXIN-1,ANTIGEN-PRESENTING CELLS,BLOOD MONONUCLEAR-CELLS,COMPLEX CLASS-I,ATOPIC-DERMATITIS,IMMUNE-RESPONSE,PROTEIN-A,MICROBIAL SUPERANTIGENS,EXFOLIATIVE TOXINS,Staphylococcus aureus,enterotoxins,nasal polyps,asthma,IgE,eosinophils},
  language     = {eng},
  number       = {8},
  pages        = {323--332},
  title        = {Staphylococcus aureus enterotoxins in airway diseases},
  volume       = {27},
  year         = {2004},
}

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