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Biocompatibility properties of surface-modified poly(dimethylsiloxane) for urinary applications

Evi Lippens (UGent) , Nele De Smet, Stijn Schauvliege (UGent) , Ann Martens (UGent) , Frank Gasthuys (UGent) , Etienne Schacht (UGent) and Maria Cornelissen (UGent)
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Abstract
An electronic sensor system for urinary bladder pressure monitoring requires an imbedding into a biocompatible, flexible, and liquid-impermeable material. Poly(dimethylsiloxane) (PDMS) was selected in the present set-up as packaging material because it fulfills the abovementioned requirements. However, the surface of PDMS is hydrophobic and causes undesired interactions with salts, proteins, and cells present in urine. To reduce possible interactions of urine salts in the urinary bladder, monomers, [2-(methacryloyloxy)ethyl]-dimethyl-3-sulfopropyl-ammonium hydroxide (sulfobetaine) and 2-acrylamido-2-methylpropyl sulfonic acid, were grafted onto the surface through oxygen plasma treatment. A reduction in salt deposition between the pure PDMS and the modified PDMS was observed both in vitro (artificial urine flow over the surface) and in vivo (implants into the urinary bladder of experimental pigs). Additionally, a 10-fold reduction in salt deposition was observed in vitro due to grafting of the monomers onto the surface. These modified PDMS materials proved also to be biocompatible in cell cultures, which was further confirmed by histological screening of the bladder tissue after implantation in an in vivo pig model.
Keywords
AMPS, sulfobetaine, salt deposition, urinary bladder implant, plasma treatment, Surface modification, BIOMATERIAL ENCRUSTATION, POLYDIMETHYLSILOXANE, SULFOBETAINE, PLASMA, PRESSURE, POLYMERS, IMPROVE, TRACT, MODEL

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MLA
Lippens, Evi, Nele De Smet, Stijn Schauvliege, et al. “Biocompatibility Properties of Surface-modified Poly(dimethylsiloxane) for Urinary Applications.” JOURNAL OF BIOMATERIALS APPLICATIONS 27.6 (2013): 651–660. Print.
APA
Lippens, E., De Smet, N., Schauvliege, S., Martens, A., Gasthuys, F., Schacht, E., & Cornelissen, M. (2013). Biocompatibility properties of surface-modified poly(dimethylsiloxane) for urinary applications. JOURNAL OF BIOMATERIALS APPLICATIONS, 27(6), 651–660.
Chicago author-date
Lippens, Evi, Nele De Smet, Stijn Schauvliege, Ann Martens, Frank Gasthuys, Etienne Schacht, and Maria Cornelissen. 2013. “Biocompatibility Properties of Surface-modified Poly(dimethylsiloxane) for Urinary Applications.” Journal of Biomaterials Applications 27 (6): 651–660.
Chicago author-date (all authors)
Lippens, Evi, Nele De Smet, Stijn Schauvliege, Ann Martens, Frank Gasthuys, Etienne Schacht, and Maria Cornelissen. 2013. “Biocompatibility Properties of Surface-modified Poly(dimethylsiloxane) for Urinary Applications.” Journal of Biomaterials Applications 27 (6): 651–660.
Vancouver
1.
Lippens E, De Smet N, Schauvliege S, Martens A, Gasthuys F, Schacht E, et al. Biocompatibility properties of surface-modified poly(dimethylsiloxane) for urinary applications. JOURNAL OF BIOMATERIALS APPLICATIONS. 2013;27(6):651–60.
IEEE
[1]
E. Lippens et al., “Biocompatibility properties of surface-modified poly(dimethylsiloxane) for urinary applications,” JOURNAL OF BIOMATERIALS APPLICATIONS, vol. 27, no. 6, pp. 651–660, 2013.
@article{3133118,
  abstract     = {An electronic sensor system for urinary bladder pressure monitoring requires an imbedding into a biocompatible, flexible, and liquid-impermeable material. Poly(dimethylsiloxane) (PDMS) was selected in the present set-up as packaging material because it fulfills the abovementioned requirements. However, the surface of PDMS is hydrophobic and causes undesired interactions with salts, proteins, and cells present in urine. To reduce possible interactions of urine salts in the urinary bladder, monomers, [2-(methacryloyloxy)ethyl]-dimethyl-3-sulfopropyl-ammonium hydroxide (sulfobetaine) and 2-acrylamido-2-methylpropyl sulfonic acid, were grafted onto the surface through oxygen plasma treatment. A reduction in salt deposition between the pure PDMS and the modified PDMS was observed both in vitro (artificial urine flow over the surface) and in vivo (implants into the urinary bladder of experimental pigs). Additionally, a 10-fold reduction in salt deposition was observed in vitro due to grafting of the monomers onto the surface. These modified PDMS materials proved also to be biocompatible in cell cultures, which was further confirmed by histological screening of the bladder tissue after implantation in an in vivo pig model.},
  author       = {Lippens, Evi and De Smet, Nele and Schauvliege, Stijn and Martens, Ann and Gasthuys, Frank and Schacht, Etienne and Cornelissen, Maria},
  issn         = {0885-3282},
  journal      = {JOURNAL OF BIOMATERIALS APPLICATIONS},
  keywords     = {AMPS,sulfobetaine,salt deposition,urinary bladder implant,plasma treatment,Surface modification,BIOMATERIAL ENCRUSTATION,POLYDIMETHYLSILOXANE,SULFOBETAINE,PLASMA,PRESSURE,POLYMERS,IMPROVE,TRACT,MODEL},
  language     = {eng},
  number       = {6},
  pages        = {651--660},
  title        = {Biocompatibility properties of surface-modified poly(dimethylsiloxane) for urinary applications},
  url          = {http://dx.doi.org/10.1177/0885328211422119},
  volume       = {27},
  year         = {2013},
}

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