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Neurobehavioral function and low-level exposure to brominated flame retardants in adolescents: a cross-sectional study

Michał Kiciński, Mineke K Viaene, Elly Den Hond, Greet Schoeters, Adrian Covaci, Alin C Dirtu, Vera Nelen, Liesbeth Bruckers, Kim Croes, Isabelle Sioen UGent, et al. (2012) ENVIRONMENTAL HEALTH. 11.
abstract
Background: Animal and in vitro studies demonstrated a neurotoxic potential of brominated flame retardants, a group of chemicals used in many household and commercial products to prevent fire. Although the first reports of detrimental neurobehavioral effects in rodents appeared more than ten years ago, human data are sparse. Methods: As a part of a biomonitoring program for environmental health surveillance in Flanders, Belgium, we assessed the neurobehavioral function with the Neurobehavioral Evaluation System (NES-3), and collected blood samples in a group of high school students. Cross-sectional data on 515 adolescents (13.6-17 years of age) was available for the analysis. Multiple regression models accounting for potential confounders were used to investigate the associations between biomarkers of internal exposure to brominated flame retardants [serum levels of polybrominated diphenyl ether (PBDE) congeners 47, 99, 100, 153, 209, hexabromocyclododecane (HBCD), and tetrabromobisphenol A (TBBPA)] and cognitive performance. In addition, we investigated the association between brominated flame retardants and serum levels of FT3, FT4, and TSH. Results: A two-fold increase of the sum of serum PBDE's was associated with a decrease of the number of taps with the preferred-hand in the Finger Tapping test by 5.31 (95% CI: 0.56 to 10.05, p = 0.029). The effects of the individual PBDE congeners on the motor speed were consistent. Serum levels above the level of quantification were associated with an average decrease of FT3 level by 0.18 pg/mL (95% CI: 0.03 to 0.34, p = 0.020) for PBDE-99 and by 0.15 pg/mL (95% CI: 0.004 to 0.29, p = 0.045) for PBDE-100, compared with concentrations below the level of quantification. PBDE-47 level above the level of quantification was associated with an average increase of TSH levels by 10.1% (95% CI: 0.8% to 20.2%, p = 0.033), compared with concentrations below the level of quantification. We did not observe effects of PBDE's on neurobehavioral domains other than the motor function. HBCD and TBBPA did not show consistent associations with performance in the neurobehavioral tests. Conclusions: This study is one of few studies and so far the largest one investigating the neurobehavioral effects of brominated flame retardants in humans. Consistently with experimental animal data, PBDE exposure was associated with changes in the motor function and the serum levels of the thyroid hormones.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ADULT MICE, SPONTANEOUS BEHAVIOR, LOW-DOSE BDE-47, NEONATAL BRAIN-DEVELOPMENT, THYROID-HORMONE DISRUPTION, POLYBROMINATED DIPHENYL ETHERS, Adolescents, Cognition, Cognitive function, Neurobehavioral function, Neurotoxicity, HBCD, TBBPA, PBDE, Brominated flame retardants, DEVELOPMENTAL EXPOSURE, 2, 2', 4, 4', 5-PENTABROMODIPHENYL ETHER, POLYCHLORINATED-BIPHENYLS, PERINATAL EXPOSURE
journal title
ENVIRONMENTAL HEALTH
Environ. Health
volume
11
article number
86
pages
12 pages
Web of Science type
Article
Web of Science id
000312646000001
JCR category
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
JCR impact factor
2.714 (2012)
JCR rank
34/157 (2012)
JCR quartile
1 (2012)
ISSN
1476-069X
DOI
10.1186/1476-069X-11-86
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
3133015
handle
http://hdl.handle.net/1854/LU-3133015
date created
2013-02-15 15:17:51
date last changed
2016-12-21 15:42:09
@article{3133015,
  abstract     = {Background: Animal and in vitro studies demonstrated a neurotoxic potential of brominated flame retardants, a group of chemicals used in many household and commercial products to prevent fire. Although the first reports of detrimental neurobehavioral effects in rodents appeared more than ten years ago, human data are sparse. 
Methods: As a part of a biomonitoring program for environmental health surveillance in Flanders, Belgium, we assessed the neurobehavioral function with the Neurobehavioral Evaluation System (NES-3), and collected blood samples in a group of high school students. Cross-sectional data on 515 adolescents (13.6-17 years of age) was available for the analysis. Multiple regression models accounting for potential confounders were used to investigate the associations between biomarkers of internal exposure to brominated flame retardants [serum levels of polybrominated diphenyl ether (PBDE) congeners 47, 99, 100, 153, 209, hexabromocyclododecane (HBCD), and tetrabromobisphenol A (TBBPA)] and cognitive performance. In addition, we investigated the association between brominated flame retardants and serum levels of FT3, FT4, and TSH. 
Results: A two-fold increase of the sum of serum PBDE's was associated with a decrease of the number of taps with the preferred-hand in the Finger Tapping test by 5.31 (95\% CI: 0.56 to 10.05, p = 0.029). The effects of the individual PBDE congeners on the motor speed were consistent. Serum levels above the level of quantification were associated with an average decrease of FT3 level by 0.18 pg/mL (95\% CI: 0.03 to 0.34, p = 0.020) for PBDE-99 and by 0.15 pg/mL (95\% CI: 0.004 to 0.29, p = 0.045) for PBDE-100, compared with concentrations below the level of quantification. PBDE-47 level above the level of quantification was associated with an average increase of TSH levels by 10.1\% (95\% CI: 0.8\% to 20.2\%, p = 0.033), compared with concentrations below the level of quantification. We did not observe effects of PBDE's on neurobehavioral domains other than the motor function. HBCD and TBBPA did not show consistent associations with performance in the neurobehavioral tests. 
Conclusions: This study is one of few studies and so far the largest one investigating the neurobehavioral effects of brominated flame retardants in humans. Consistently with experimental animal data, PBDE exposure was associated with changes in the motor function and the serum levels of the thyroid hormones.},
  articleno    = {86},
  author       = {Kici\'{n}ski, Micha\unmatched{0142} and Viaene, Mineke K and Den Hond, Elly and Schoeters, Greet and Covaci, Adrian and Dirtu, Alin C and Nelen, Vera and Bruckers, Liesbeth and Croes, Kim and Sioen, Isabelle and Baeyens, Willy and Van Larebeke, Nicolas and Nawrot, Tim S},
  issn         = {1476-069X},
  journal      = {ENVIRONMENTAL HEALTH},
  keyword      = {ADULT MICE,SPONTANEOUS BEHAVIOR,LOW-DOSE BDE-47,NEONATAL BRAIN-DEVELOPMENT,THYROID-HORMONE DISRUPTION,POLYBROMINATED DIPHENYL ETHERS,Adolescents,Cognition,Cognitive function,Neurobehavioral function,Neurotoxicity,HBCD,TBBPA,PBDE,Brominated flame retardants,DEVELOPMENTAL EXPOSURE,2,2',4,4',5-PENTABROMODIPHENYL ETHER,POLYCHLORINATED-BIPHENYLS,PERINATAL EXPOSURE},
  language     = {eng},
  pages        = {12},
  title        = {Neurobehavioral function and low-level exposure to brominated flame retardants in adolescents: a cross-sectional study},
  url          = {http://dx.doi.org/10.1186/1476-069X-11-86},
  volume       = {11},
  year         = {2012},
}

Chicago
Kiciński, Michał, Mineke K Viaene, Elly Den Hond, Greet Schoeters, Adrian Covaci, Alin C Dirtu, Vera Nelen, et al. 2012. “Neurobehavioral Function and Low-level Exposure to Brominated Flame Retardants in Adolescents: a Cross-sectional Study.” Environmental Health 11.
APA
Kiciński, M., Viaene, M. K., Den Hond, E., Schoeters, G., Covaci, A., Dirtu, A. C., Nelen, V., et al. (2012). Neurobehavioral function and low-level exposure to brominated flame retardants in adolescents: a cross-sectional study. ENVIRONMENTAL HEALTH, 11.
Vancouver
1.
Kiciński M, Viaene MK, Den Hond E, Schoeters G, Covaci A, Dirtu AC, et al. Neurobehavioral function and low-level exposure to brominated flame retardants in adolescents: a cross-sectional study. ENVIRONMENTAL HEALTH. 2012;11.
MLA
Kiciński, Michał, Mineke K Viaene, Elly Den Hond, et al. “Neurobehavioral Function and Low-level Exposure to Brominated Flame Retardants in Adolescents: a Cross-sectional Study.” ENVIRONMENTAL HEALTH 11 (2012): n. pag. Print.