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Comparison of cortical 5-HT2A receptor binding in bulimia nervosa patients and healthy volunteers

(2004) AMERICAN JOURNAL OF PSYCHIATRY. 161(10). p.1916-1918
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Abstract
Objective: Bulimia nervosa has been associated with alterations in central serotonergic (5-HT) function. This study investigated iodine-labeled 4-amino-N-[1-[3-(4-fluorophenoxy) propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide ((123)l-5-l-R91150) binding to the 5-HT2A receptor in the brain by usingsingle photon emission computed tomography in acutely ill bulimia nervosa patients. Method: Cortical (123)l-5-l-R91150 binding in 10 normal-weight patients with bulimia nervosa, purging type, was compared with that of 11 healthy volunteers. Results: The 5-HT2A binding index of the bulimia nervosa patients, with and without correction for age, was not significantly different from that of the comparison group. Conclusions: As a group, acutely ill bulimia nervosa patients cannot be discriminated from healthy subjects on the basis of cortical (123)l-5-l-R91150 binding to the 5-HT2A receptor.
Keywords
PHOTON-EMISSION-TOMOGRAPHY, LIGAND, BRAIN

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Chicago
Goethals, Ingeborg, Myriam Vervaet, Kurt Audenaert, Christophe Van De Wiele, Hamphrey Ham, Marleen Vandecapelle, Guido Slegers, Rudi Dierckx, and Cornelis Van Heeringen. 2004. “Comparison of Cortical 5-HT2A Receptor Binding in Bulimia Nervosa Patients and Healthy Volunteers.” American Journal of Psychiatry 161 (10): 1916–1918.
APA
Goethals, Ingeborg, Vervaet, M., Audenaert, K., Van De Wiele, C., Ham, H., Vandecapelle, M., Slegers, G., et al. (2004). Comparison of cortical 5-HT2A receptor binding in bulimia nervosa patients and healthy volunteers. AMERICAN JOURNAL OF PSYCHIATRY, 161(10), 1916–1918.
Vancouver
1.
Goethals I, Vervaet M, Audenaert K, Van De Wiele C, Ham H, Vandecapelle M, et al. Comparison of cortical 5-HT2A receptor binding in bulimia nervosa patients and healthy volunteers. AMERICAN JOURNAL OF PSYCHIATRY. 2004;161(10):1916–8.
MLA
Goethals, Ingeborg, Myriam Vervaet, Kurt Audenaert, et al. “Comparison of Cortical 5-HT2A Receptor Binding in Bulimia Nervosa Patients and Healthy Volunteers.” AMERICAN JOURNAL OF PSYCHIATRY 161.10 (2004): 1916–1918. Print.
@article{313095,
  abstract     = {Objective: Bulimia nervosa has been associated with alterations in central serotonergic (5-HT) function. This study investigated iodine-labeled 4-amino-N-[1-[3-(4-fluorophenoxy) propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide ((123)l-5-l-R91150) binding to the 5-HT2A receptor in the brain by usingsingle photon emission computed tomography in acutely ill bulimia nervosa patients.
Method: Cortical (123)l-5-l-R91150 binding in 10 normal-weight patients with bulimia nervosa, purging type, was compared with that of 11 healthy volunteers.
Results: The 5-HT2A binding index of the bulimia nervosa patients, with and without correction for age, was not significantly different from that of the comparison group.
Conclusions: As a group, acutely ill bulimia nervosa patients cannot be discriminated from healthy subjects on the basis of cortical (123)l-5-l-R91150 binding to the 5-HT2A receptor.},
  author       = {Goethals, Ingeborg and Vervaet, Myriam and Audenaert, Kurt and Van De Wiele, Christophe and Ham, Hamphrey and Vandecapelle, Marleen and Slegers, Guido and Dierckx, Rudi and Van Heeringen, Cornelis},
  issn         = {0002-953X},
  journal      = {AMERICAN JOURNAL OF PSYCHIATRY},
  language     = {eng},
  number       = {10},
  pages        = {1916--1918},
  title        = {Comparison of cortical 5-HT2A receptor binding in bulimia nervosa patients and healthy volunteers},
  url          = {http://dx.doi.org/10.1176/appi.ajp.161.10.1916},
  volume       = {161},
  year         = {2004},
}

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