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Genome-wide analysis of the globin gene family of C. elegans

(2004) IUBMB LIFE. 56(11-12). p.697-702
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Abstract
The aim of our study was to annotate sequences for 35 putative globins from the nematode Caenorhabditis elegans. All these proteins are expressed, but seven of these differ from the gene predictions in Wormbase. The entire polypeptide sequences for 31 genes and the core globin domain of four proteins were confirmed or corrected. All core globin domains were aligned manually following a procedure that was designed to fit the putative sequences to the crystal structure based alignment of 56 known globin crystal structures. Neighbor-joining analysis of the resulting alignment showed that the majority of these globins are very divergent from each other, possibly suggesting a long evolutionary divergence. The surprisingly high number and low sequence conservation of putative globins in this small organism urges a detailed functional analysis.
Keywords
CAENORHABDITIS-ELEGANS, globins, AMINO-ACID-SEQUENCES, oxygen affinity, Caenorhabditis elegans, RESPIRATORY PROTEIN, LIGAND-BINDING, NEUROGLOBIN, HEMOGLOBIN, EXPRESSION, NEURONS, ORIGIN, VOLUME

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Citation

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Chicago
Hoogewijs, David, Eva Geuens, Sylvia Dewilde, Luc Moens, Andy Vierstraete, Serge N Vinogradov, and Jacques Vanfleteren. 2004. “Genome-wide Analysis of the Globin Gene Family of C. Elegans.” Iubmb Life 56 (11-12): 697–702.
APA
Hoogewijs, D., Geuens, E., Dewilde, S., Moens, L., Vierstraete, A., Vinogradov, S. N., & Vanfleteren, J. (2004). Genome-wide analysis of the globin gene family of C. elegans. IUBMB LIFE, 56(11-12), 697–702. Presented at the Annual meeting of the European FP5 Network.
Vancouver
1.
Hoogewijs D, Geuens E, Dewilde S, Moens L, Vierstraete A, Vinogradov SN, et al. Genome-wide analysis of the globin gene family of C. elegans. IUBMB LIFE. 2004;56(11-12):697–702.
MLA
Hoogewijs, David, Eva Geuens, Sylvia Dewilde, et al. “Genome-wide Analysis of the Globin Gene Family of C. Elegans.” IUBMB LIFE 56.11-12 (2004): 697–702. Print.
@article{312962,
  abstract     = {The aim of our study was to annotate sequences for 35 putative globins from the nematode Caenorhabditis elegans. All these proteins are expressed, but seven of these differ from the gene predictions in Wormbase. The entire polypeptide sequences for 31 genes and the core globin domain of four proteins were confirmed or corrected. All core globin domains were aligned manually following a procedure that was designed to fit the putative sequences to the crystal structure based alignment of 56 known globin crystal structures. Neighbor-joining analysis of the resulting alignment showed that the majority of these globins are very divergent from each other, possibly suggesting a long evolutionary divergence. The surprisingly high number and low sequence conservation of putative globins in this small organism urges a detailed functional analysis.},
  author       = {Hoogewijs, David and Geuens, Eva and Dewilde, Sylvia and Moens, Luc and Vierstraete, Andy and Vinogradov, Serge N and Vanfleteren, Jacques},
  issn         = {1521-6543},
  journal      = {IUBMB LIFE},
  language     = {eng},
  location     = {Genoa, Italy},
  number       = {11-12},
  pages        = {697--702},
  title        = {Genome-wide analysis of the globin gene family of C. elegans},
  url          = {http://dx.doi.org/10.1080/15216540500037562},
  volume       = {56},
  year         = {2004},
}

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