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Nerve globins in invertebrates

(2004) IUBMB LIFE. 56(11-12). p.653-656
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Abstract
The expression of nerve hemoglobins in invertebrates is a well-established fact, but this occurrence is uncommon. In the species where nerve globins occur, they probably function as an oxygen store for sustaining activity of the nerves during anoxic conditions. Although invertebrate nerve globins are functionally similar with respect to O-2 a finity, they are by no means uniform in structure and can differ in size, cellular localization and heme-coordination. The best-studied nerve globin is the mini-globin of Cerebratulus lacteus, which belongs to a class of globins containing the polar TyrB10/GlnE7 pair in the distal pocket. The amide and phenol side chains normally cause low rates of O-2 dissociation and ultra-high O-2 affinity by forming strong hydrogen bonds with bound ligands. Cerebratulus hemoglobin, however, has a moderate O-2 affinity, due to the presence of a third polar amino-acid in its active site, ThrE11, which inhibits hydrogen bonding to bound oxygen by the B10 tyrosine side chain.
Keywords
invertebrates, nerve globins, oxygen affinity, CEREBRATULUS-LACTEUS, LIGAND-BINDING, HEMOGLOBIN, MYOGLOBIN, AFFINITY, PROTEIN, APLYSIA, TISSUE, FOLD

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Citation

Please use this url to cite or link to this publication:

MLA
Geuens, Eva, Sylvia Dewilde, David Hoogewijs, et al. “Nerve Globins in Invertebrates.” IUBMB LIFE 56.11-12 (2004): 653–656. Print.
APA
Geuens, E., Dewilde, S., Hoogewijs, D., Pesce, A., Nienhaus, K., Nienhaus, G., Olson, J., et al. (2004). Nerve globins in invertebrates. IUBMB LIFE, 56(11-12), 653–656. Presented at the Annual meeting of the European FP5 Network.
Chicago author-date
Geuens, Eva, Sylvia Dewilde, David Hoogewijs, Alessandra Pesce, K Nienhaus, GU Nienhaus, J Olson, Jacques Vanfleteren, Martino Bolognesi, and Luc Moens. 2004. “Nerve Globins in Invertebrates.” Iubmb Life 56 (11-12): 653–656.
Chicago author-date (all authors)
Geuens, Eva, Sylvia Dewilde, David Hoogewijs, Alessandra Pesce, K Nienhaus, GU Nienhaus, J Olson, Jacques Vanfleteren, Martino Bolognesi, and Luc Moens. 2004. “Nerve Globins in Invertebrates.” Iubmb Life 56 (11-12): 653–656.
Vancouver
1.
Geuens E, Dewilde S, Hoogewijs D, Pesce A, Nienhaus K, Nienhaus G, et al. Nerve globins in invertebrates. IUBMB LIFE. 2004;56(11-12):653–6.
IEEE
[1]
E. Geuens et al., “Nerve globins in invertebrates,” IUBMB LIFE, vol. 56, no. 11–12, pp. 653–656, 2004.
@article{312954,
  abstract     = {The expression of nerve hemoglobins in invertebrates is a well-established fact, but this occurrence is uncommon. In the species where nerve globins occur, they probably function as an oxygen store for sustaining activity of the nerves during anoxic conditions. Although invertebrate nerve globins are functionally similar with respect to O-2 a finity, they are by no means uniform in structure and can differ in size, cellular localization and heme-coordination. The best-studied nerve globin is the mini-globin of Cerebratulus lacteus, which belongs to a class of globins containing the polar TyrB10/GlnE7 pair in the distal pocket. The amide and phenol side chains normally cause low rates of O-2 dissociation and ultra-high O-2 affinity by forming strong hydrogen bonds with bound ligands. Cerebratulus hemoglobin, however, has a moderate O-2 affinity, due to the presence of a third polar amino-acid in its active site, ThrE11, which inhibits hydrogen bonding to bound oxygen by the B10 tyrosine side chain.},
  author       = {Geuens, Eva and Dewilde, Sylvia and Hoogewijs, David and Pesce, Alessandra and Nienhaus, K and Nienhaus, GU and Olson, J and Vanfleteren, Jacques and Bolognesi, Martino and Moens, Luc},
  issn         = {1521-6543},
  journal      = {IUBMB LIFE},
  keywords     = {invertebrates,nerve globins,oxygen affinity,CEREBRATULUS-LACTEUS,LIGAND-BINDING,HEMOGLOBIN,MYOGLOBIN,AFFINITY,PROTEIN,APLYSIA,TISSUE,FOLD},
  language     = {eng},
  location     = {Genoa, Italy},
  number       = {11-12},
  pages        = {653--656},
  title        = {Nerve globins in invertebrates},
  url          = {http://dx.doi.org/10.1080/15216540500037471},
  volume       = {56},
  year         = {2004},
}

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