- Author
- Ivano Amelio (UGent) , Francesca Grespi (UGent) , Margherita Annicchiarico-Petruzzelli and Gennaro Melino (UGent)
- Organization
- Abstract
- p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isoform (Delta N isoform). Complete ablation of all p63 isoforms produced mice with fatal developmental abnormalities, including lack of epidermal barrier, limbs and other epidermal appendages. Specific TAp63-null mice, although they developed normally, failed to undergo in DNA damage-induced apoptosis during primordial follicle meiotic arrest, suggesting a p63 involvement in maternal reproduction. Recent findings have elucidated the role in DNA damage response of a novel Hominidae p63 isoform, GTAp63, specifically expressed in human spermatic precursors. Thus, these findings suggest a unique strategy of p63 gene, to evolve in order to preserve the species as a guardian of reproduction. Elucidation of the biological basis of p63 function in reproduction may provide novel approaches to the control of human fertility.
- Keywords
- oocytes, reproduction, p63, spermatozoa, DNA damage, p53, c-Abl, TUMOR-SUPPRESSOR P53, GERM-CELL APOPTOSIS, NF-KAPPA-B, DNA-DAMAGE, CANCER-CELLS, MUTANT P53, P53-DEPENDENT APOPTOSIS, EPITHELIAL DEVELOPMENT, CARCINOMA-CELLS, QUALITY-CONTROL
Downloads
-
(...).pdf
- full text
- |
- UGent only
- |
- |
- 582.54 KB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-3129228
- MLA
- Amelio, Ivano, et al. “P63 the Guardian of Human Reproduction.” CELL CYCLE, vol. 11, no. 24, 2012, pp. 4545–51, doi:10.4161/cc.22819.
- APA
- Amelio, I., Grespi, F., Annicchiarico-Petruzzelli, M., & Melino, G. (2012). p63 the guardian of human reproduction. CELL CYCLE, 11(24), 4545–4551. https://doi.org/10.4161/cc.22819
- Chicago author-date
- Amelio, Ivano, Francesca Grespi, Margherita Annicchiarico-Petruzzelli, and Gennaro Melino. 2012. “P63 the Guardian of Human Reproduction.” CELL CYCLE 11 (24): 4545–51. https://doi.org/10.4161/cc.22819.
- Chicago author-date (all authors)
- Amelio, Ivano, Francesca Grespi, Margherita Annicchiarico-Petruzzelli, and Gennaro Melino. 2012. “P63 the Guardian of Human Reproduction.” CELL CYCLE 11 (24): 4545–4551. doi:10.4161/cc.22819.
- Vancouver
- 1.Amelio I, Grespi F, Annicchiarico-Petruzzelli M, Melino G. p63 the guardian of human reproduction. CELL CYCLE. 2012;11(24):4545–51.
- IEEE
- [1]I. Amelio, F. Grespi, M. Annicchiarico-Petruzzelli, and G. Melino, “p63 the guardian of human reproduction,” CELL CYCLE, vol. 11, no. 24, pp. 4545–4551, 2012.
@article{3129228, abstract = {{p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isoform (Delta N isoform). Complete ablation of all p63 isoforms produced mice with fatal developmental abnormalities, including lack of epidermal barrier, limbs and other epidermal appendages. Specific TAp63-null mice, although they developed normally, failed to undergo in DNA damage-induced apoptosis during primordial follicle meiotic arrest, suggesting a p63 involvement in maternal reproduction. Recent findings have elucidated the role in DNA damage response of a novel Hominidae p63 isoform, GTAp63, specifically expressed in human spermatic precursors. Thus, these findings suggest a unique strategy of p63 gene, to evolve in order to preserve the species as a guardian of reproduction. Elucidation of the biological basis of p63 function in reproduction may provide novel approaches to the control of human fertility.}}, author = {{Amelio, Ivano and Grespi, Francesca and Annicchiarico-Petruzzelli, Margherita and Melino, Gennaro}}, issn = {{1538-4101}}, journal = {{CELL CYCLE}}, keywords = {{oocytes,reproduction,p63,spermatozoa,DNA damage,p53,c-Abl,TUMOR-SUPPRESSOR P53,GERM-CELL APOPTOSIS,NF-KAPPA-B,DNA-DAMAGE,CANCER-CELLS,MUTANT P53,P53-DEPENDENT APOPTOSIS,EPITHELIAL DEVELOPMENT,CARCINOMA-CELLS,QUALITY-CONTROL}}, language = {{eng}}, number = {{24}}, pages = {{4545--4551}}, title = {{p63 the guardian of human reproduction}}, url = {{http://doi.org/10.4161/cc.22819}}, volume = {{11}}, year = {{2012}}, }
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: