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p63 the guardian of human reproduction

(2012) CELL CYCLE. 11(24). p.4545-4551
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Abstract
p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isoform (Delta N isoform). Complete ablation of all p63 isoforms produced mice with fatal developmental abnormalities, including lack of epidermal barrier, limbs and other epidermal appendages. Specific TAp63-null mice, although they developed normally, failed to undergo in DNA damage-induced apoptosis during primordial follicle meiotic arrest, suggesting a p63 involvement in maternal reproduction. Recent findings have elucidated the role in DNA damage response of a novel Hominidae p63 isoform, GTAp63, specifically expressed in human spermatic precursors. Thus, these findings suggest a unique strategy of p63 gene, to evolve in order to preserve the species as a guardian of reproduction. Elucidation of the biological basis of p63 function in reproduction may provide novel approaches to the control of human fertility.
Keywords
oocytes, reproduction, p63, spermatozoa, DNA damage, p53, c-Abl, TUMOR-SUPPRESSOR P53, GERM-CELL APOPTOSIS, NF-KAPPA-B, DNA-DAMAGE, CANCER-CELLS, MUTANT P53, P53-DEPENDENT APOPTOSIS, EPITHELIAL DEVELOPMENT, CARCINOMA-CELLS, QUALITY-CONTROL

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Citation

Please use this url to cite or link to this publication:

MLA
Amelio, Ivano, et al. “P63 the Guardian of Human Reproduction.” CELL CYCLE, vol. 11, no. 24, 2012, pp. 4545–51, doi:10.4161/cc.22819.
APA
Amelio, I., Grespi, F., Annicchiarico-Petruzzelli, M., & Melino, G. (2012). p63 the guardian of human reproduction. CELL CYCLE, 11(24), 4545–4551. https://doi.org/10.4161/cc.22819
Chicago author-date
Amelio, Ivano, Francesca Grespi, Margherita Annicchiarico-Petruzzelli, and Gennaro Melino. 2012. “P63 the Guardian of Human Reproduction.” CELL CYCLE 11 (24): 4545–51. https://doi.org/10.4161/cc.22819.
Chicago author-date (all authors)
Amelio, Ivano, Francesca Grespi, Margherita Annicchiarico-Petruzzelli, and Gennaro Melino. 2012. “P63 the Guardian of Human Reproduction.” CELL CYCLE 11 (24): 4545–4551. doi:10.4161/cc.22819.
Vancouver
1.
Amelio I, Grespi F, Annicchiarico-Petruzzelli M, Melino G. p63 the guardian of human reproduction. CELL CYCLE. 2012;11(24):4545–51.
IEEE
[1]
I. Amelio, F. Grespi, M. Annicchiarico-Petruzzelli, and G. Melino, “p63 the guardian of human reproduction,” CELL CYCLE, vol. 11, no. 24, pp. 4545–4551, 2012.
@article{3129228,
  abstract     = {{p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isoform (Delta N isoform). Complete ablation of all p63 isoforms produced mice with fatal developmental abnormalities, including lack of epidermal barrier, limbs and other epidermal appendages. Specific TAp63-null mice, although they developed normally, failed to undergo in DNA damage-induced apoptosis during primordial follicle meiotic arrest, suggesting a p63 involvement in maternal reproduction. Recent findings have elucidated the role in DNA damage response of a novel Hominidae p63 isoform, GTAp63, specifically expressed in human spermatic precursors. Thus, these findings suggest a unique strategy of p63 gene, to evolve in order to preserve the species as a guardian of reproduction. Elucidation of the biological basis of p63 function in reproduction may provide novel approaches to the control of human fertility.}},
  author       = {{Amelio, Ivano and Grespi, Francesca and Annicchiarico-Petruzzelli, Margherita and Melino, Gennaro}},
  issn         = {{1538-4101}},
  journal      = {{CELL CYCLE}},
  keywords     = {{oocytes,reproduction,p63,spermatozoa,DNA damage,p53,c-Abl,TUMOR-SUPPRESSOR P53,GERM-CELL APOPTOSIS,NF-KAPPA-B,DNA-DAMAGE,CANCER-CELLS,MUTANT P53,P53-DEPENDENT APOPTOSIS,EPITHELIAL DEVELOPMENT,CARCINOMA-CELLS,QUALITY-CONTROL}},
  language     = {{eng}},
  number       = {{24}},
  pages        = {{4545--4551}},
  title        = {{p63 the guardian of human reproduction}},
  url          = {{http://doi.org/10.4161/cc.22819}},
  volume       = {{11}},
  year         = {{2012}},
}

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