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Effects of hunter-gatherer subsistence mode on arterial distensibility in Cameroonian pygmies

Daniel Lemogoum, William Ngatchou, Christophe Janssen, Marc Leeman, Lucas Van Bortel, Pierre Boutouyrie, Jean Paul Degaute and Philippe Van de Borne (2012) HYPERTENSION. 60(1). p.123-128
abstract
We aimed to assess whether arterial distensibility estimated by pulse wave velocity (PWV) and augmentation index (AI) differs between Cameroon traditional pygmies (TPs) on hunter-gather subsistence mode, contemporary pygmies who migrated to semiurban area, and the Bantou farmers (BFs) sharing the same environment. For that purpose, we recorded carotid-femoral PWV (ComplioR) in age and sex carefully matched 20 TPs, 20 contemporary pygmies, and 22 BFs. Aortic AI corrected for heart rate and blood pressures were generated from pressure wave analysis (SphygmoCor). Lipid profile was determined in TP and BF participants. TPs were shorter (P=0.02) with lower body weight (P<0.01) in comparison with contemporary pygmies and BFs. TPs had lower low-density lipoprotein cholesterol but higher high-density lipoprotein cholesterol than BFs (P<0.01). Their PWV (5.81 +/- 0.21 m/s) was slower (P=0.006) than that of contemporary pygmies (6.82 +/- 0.36 m/s) or BFs (6.93 +/- 0.29 m/s); however, after its adjustment for age, mean arterial pressure, and heart rate, the difference was slightly attenuated (P=0.051). PWV adjusted for weight did not differ between groups (P=0.10). In the whole study population but not in TPs taken separately, multivariate regression analysis revealed that PWV was independently associated with mean arterial pressure, age, and TP status (P<0.001), whereas age, mean arterial pressure, and height emerged as independent determinants of aortic AI corrected for heart rate (P<0.001). Aortic AI corrected for heart rate did not differ in the 3 groups. In conclusion, hunter-gather lifestyle is associated with low atherosclerosis risk translated by lower aortic stiffness attributed at least partly to low weight and blunted effects of aging and blood pressures on TP arterial structure and function.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
arterial stiffness, pulse wave velocity, augmentation index, atherosclerosis, lifestyle, pygmies, bantou, PULSE-WAVE VELOCITY, CENTRAL AORTIC PRESSURE, BLOOD-PRESSURE, AUGMENTATION INDEX, STIFFNESS, DISEASE, HYPERTENSION, AGE, HYPERCHOLESTEROLEMIA, REFLECTIONS
journal title
HYPERTENSION
Hypertension
volume
60
issue
1
pages
123 - 128
Web of Science type
Article
Web of Science id
000305574200029
JCR category
PERIPHERAL VASCULAR DISEASE
JCR impact factor
6.873 (2012)
JCR rank
3/66 (2012)
JCR quartile
1 (2012)
ISSN
0194-911X
DOI
10.1161/HYPERTENSIONAHA.111.187757
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3128969
handle
http://hdl.handle.net/1854/LU-3128969
date created
2013-02-13 11:23:10
date last changed
2016-12-19 15:46:52
@article{3128969,
  abstract     = {We aimed to assess whether arterial distensibility estimated by pulse wave velocity (PWV) and augmentation index (AI) differs between Cameroon traditional pygmies (TPs) on hunter-gather subsistence mode, contemporary pygmies who migrated to semiurban area, and the Bantou farmers (BFs) sharing the same environment. For that purpose, we recorded carotid-femoral PWV (ComplioR) in age and sex carefully matched 20 TPs, 20 contemporary pygmies, and 22 BFs. Aortic AI corrected for heart rate and blood pressures were generated from pressure wave analysis (SphygmoCor). Lipid profile was determined in TP and BF participants. TPs were shorter (P=0.02) with lower body weight (P{\textlangle}0.01) in comparison with contemporary pygmies and BFs. TPs had lower low-density lipoprotein cholesterol but higher high-density lipoprotein cholesterol than BFs (P{\textlangle}0.01). Their PWV (5.81 +/- 0.21 m/s) was slower (P=0.006) than that of contemporary pygmies (6.82 +/- 0.36 m/s) or BFs (6.93 +/- 0.29 m/s); however, after its adjustment for age, mean arterial pressure, and heart rate, the difference was slightly attenuated (P=0.051). PWV adjusted for weight did not differ between groups (P=0.10). In the whole study population but not in TPs taken separately, multivariate regression analysis revealed that PWV was independently associated with mean arterial pressure, age, and TP status (P{\textlangle}0.001), whereas age, mean arterial pressure, and height emerged as independent determinants of aortic AI corrected for heart rate (P{\textlangle}0.001). Aortic AI corrected for heart rate did not differ in the 3 groups. In conclusion, hunter-gather lifestyle is associated with low atherosclerosis risk translated by lower aortic stiffness attributed at least partly to low weight and blunted effects of aging and blood pressures on TP arterial structure and function.},
  author       = {Lemogoum, Daniel and Ngatchou, William and Janssen, Christophe and Leeman, Marc and Van Bortel, Lucas and Boutouyrie, Pierre and Degaute, Jean Paul and Van de Borne, Philippe},
  issn         = {0194-911X},
  journal      = {HYPERTENSION},
  keyword      = {arterial stiffness,pulse wave velocity,augmentation index,atherosclerosis,lifestyle,pygmies,bantou,PULSE-WAVE VELOCITY,CENTRAL AORTIC PRESSURE,BLOOD-PRESSURE,AUGMENTATION INDEX,STIFFNESS,DISEASE,HYPERTENSION,AGE,HYPERCHOLESTEROLEMIA,REFLECTIONS},
  language     = {eng},
  number       = {1},
  pages        = {123--128},
  title        = {Effects of hunter-gatherer subsistence mode on arterial distensibility in Cameroonian pygmies},
  url          = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.187757},
  volume       = {60},
  year         = {2012},
}

Chicago
Lemogoum, Daniel, William Ngatchou, Christophe Janssen, Marc Leeman, Lucas Van Bortel, Pierre Boutouyrie, Jean Paul Degaute, and Philippe Van de Borne. 2012. “Effects of Hunter-gatherer Subsistence Mode on Arterial Distensibility in Cameroonian Pygmies.” Hypertension 60 (1): 123–128.
APA
Lemogoum, Daniel, Ngatchou, W., Janssen, C., Leeman, M., Van Bortel, L., Boutouyrie, P., Degaute, J. P., et al. (2012). Effects of hunter-gatherer subsistence mode on arterial distensibility in Cameroonian pygmies. HYPERTENSION, 60(1), 123–128.
Vancouver
1.
Lemogoum D, Ngatchou W, Janssen C, Leeman M, Van Bortel L, Boutouyrie P, et al. Effects of hunter-gatherer subsistence mode on arterial distensibility in Cameroonian pygmies. HYPERTENSION. 2012;60(1):123–8.
MLA
Lemogoum, Daniel, William Ngatchou, Christophe Janssen, et al. “Effects of Hunter-gatherer Subsistence Mode on Arterial Distensibility in Cameroonian Pygmies.” HYPERTENSION 60.1 (2012): 123–128. Print.