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Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1

Veronique van den Berghe, Elke Stappers, Bram Vandesande, Jordane Dimidschstein, Roel Kroes, Annick Francis, Andrea Conidi, Flore Lesage, Ruben Dries, Silvia Cazzola, et al. (2013) NEURON. 77(1). p.70-82
abstract
GABAergic interneurons mainly originate in the medial ganglionic eminence (MGE) of the embryonic ventral telencephalon (VT) and migrate tangentially to the cortex, guided by membrane-bound and secreted factors. We found that Sip1 (Zfhx1b, Zeb2), a transcription factor enriched in migrating cortical interneurons, is required for their proper differentiation and correct guidance. The majority of Sip1 knockout interneurons fail to migrate to the neocortex and stall in the VT. RNA sequencing reveals that Sip1 knockout interneurons do not acquire a fully mature cortical interneuron identity and contain increased levels of the repulsive receptor Unc5b. Focal electroporation of Unc5b-encoding vectors in the MGE of wild-type brain slices disturbs migration to the neocortex, whereas reducing Unc5b levels in Sip1 knockout slices and brains rescues the migration defect. Our results reveal that Sip1, through tuning of Unc5b levels, is essential for cortical interneuron guidance.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GABAERGIC INTERNEURONS, TELENCEPHALIC INTERNEURONS, MOWAT-WILSON-SYNDROME, SMAD-INTERACTING PROTEIN-1, GANGLIONIC EMINENCE, GENE-EXPRESSION, NERVOUS-SYSTEM, E-CADHERIN, MOUSE, FOREBRAIN
journal title
NEURON
Neuron
volume
77
issue
1
pages
70 - 82
Web of Science type
Article
Web of Science id
000313404600009
JCR category
NEUROSCIENCES
JCR impact factor
15.982 (2013)
JCR rank
4/252 (2013)
JCR quartile
1 (2013)
ISSN
0896-6273
DOI
10.1016/j.neuron.2012.11.009
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3127253
handle
http://hdl.handle.net/1854/LU-3127253
date created
2013-02-11 13:39:06
date last changed
2016-12-19 15:43:26
@article{3127253,
  abstract     = {GABAergic interneurons mainly originate in the medial ganglionic eminence (MGE) of the embryonic ventral telencephalon (VT) and migrate tangentially to the cortex, guided by membrane-bound and secreted factors. We found that Sip1 (Zfhx1b, Zeb2), a transcription factor enriched in migrating cortical interneurons, is required for their proper differentiation and correct guidance. The majority of Sip1 knockout interneurons fail to migrate to the neocortex and stall in the VT. RNA sequencing reveals that Sip1 knockout interneurons do not acquire a fully mature cortical interneuron identity and contain increased levels of the repulsive receptor Unc5b. Focal electroporation of Unc5b-encoding vectors in the MGE of wild-type brain slices disturbs migration to the neocortex, whereas reducing Unc5b levels in Sip1 knockout slices and brains rescues the migration defect. Our results reveal that Sip1, through tuning of Unc5b levels, is essential for cortical interneuron guidance.},
  author       = {van den Berghe, Veronique and Stappers, Elke and Vandesande, Bram and Dimidschstein, Jordane and Kroes, Roel and Francis, Annick and Conidi, Andrea and Lesage, Flore and Dries, Ruben and Cazzola, Silvia and Berx, Geert and Kessaris, Nicoletta and Vanderhaeghen, Pierre and van IJcken, Wilfred and Grosveld, Frank G and Goossens, Steven and Haigh, Jody and Fishell, Gord and Goffinet, Andr{\'e} and Aerts, Stein and Huylebroeck, Danny and Seuntjens, Eve},
  issn         = {0896-6273},
  journal      = {NEURON},
  keyword      = {GABAERGIC INTERNEURONS,TELENCEPHALIC INTERNEURONS,MOWAT-WILSON-SYNDROME,SMAD-INTERACTING PROTEIN-1,GANGLIONIC EMINENCE,GENE-EXPRESSION,NERVOUS-SYSTEM,E-CADHERIN,MOUSE,FOREBRAIN},
  language     = {eng},
  number       = {1},
  pages        = {70--82},
  title        = {Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1},
  url          = {http://dx.doi.org/10.1016/j.neuron.2012.11.009},
  volume       = {77},
  year         = {2013},
}

Chicago
van den Berghe, Veronique, Elke Stappers, Bram Vandesande, Jordane Dimidschstein, Roel Kroes, Annick Francis, Andrea Conidi, et al. 2013. “Directed Migration of Cortical Interneurons Depends on the Cell-autonomous Action of Sip1.” Neuron 77 (1): 70–82.
APA
van den Berghe, V., Stappers, E., Vandesande, B., Dimidschstein, J., Kroes, R., Francis, A., Conidi, A., et al. (2013). Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1. NEURON, 77(1), 70–82.
Vancouver
1.
van den Berghe V, Stappers E, Vandesande B, Dimidschstein J, Kroes R, Francis A, et al. Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1. NEURON. 2013;77(1):70–82.
MLA
van den Berghe, Veronique, Elke Stappers, Bram Vandesande, et al. “Directed Migration of Cortical Interneurons Depends on the Cell-autonomous Action of Sip1.” NEURON 77.1 (2013): 70–82. Print.