Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia
- Author
- Irene Homminga, Rob Pieters, Anton W Langerak, Johan J de Rooi, Andrew Stubbs, Monique Verstegen, Maartje Vuerhard, Jessica Buijs-Gladdines, Clarissa Kooi, Petra Klous, Pieter Van Vlierberghe (UGent) , Adolfo A Ferrando, Jean Michel Cayuela, Brenda Verhaaf, H Berna Beverloo, Martin Horstmann, Valerie de Haas, Anna-Sophia Wiekmeijer, Karin Pike-Overzet, Frank JT Staal, Wouter de Laat, Jean Soulier, François Sigaux and Jules PP Meijerink
- Organization
- Abstract
- To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed molecular-cytogenetic analyses including the Chromosome Conformation Capture on Chip (4C) method. Two T-ALL subtypes were identified that lacked rearrangements of known oncogenes. One subtype associated with cortical arrest, expression of cell cycle genes, and ectopic NKX2-1 or NKX2-2 expression for which rearrangements were identified. The second subtype associated with immature T cell development and high expression of the MEF2C transcription factor as consequence of rearrangements of MEF2C, transcription factors that target MEF2C, or MEF2C-associated cofactors. We propose NKX2-1, NKX2-2, and MEF2C as T-ALL oncogenes that are activated by various rearrangements.
- Keywords
- TARGET GENE, C-MYC, HOMEOBOX GENE, ACTIVATION MECHANISM, GENE-EXPRESSION, FUSION, CANCER, NOTCH1, IDENTIFICATION, TRANSFORMATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-3126508
- MLA
- Homminga, Irene, et al. “Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia.” CANCER CELL, vol. 19, no. 4, 2011, pp. 484–97, doi:10.1016/j.ccr.2011.02.008.
- APA
- Homminga, I., Pieters, R., Langerak, A. W., de Rooi, J. J., Stubbs, A., Verstegen, M., … Meijerink, J. P. (2011). Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. CANCER CELL, 19(4), 484–497. https://doi.org/10.1016/j.ccr.2011.02.008
- Chicago author-date
- Homminga, Irene, Rob Pieters, Anton W Langerak, Johan J de Rooi, Andrew Stubbs, Monique Verstegen, Maartje Vuerhard, et al. 2011. “Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia.” CANCER CELL 19 (4): 484–97. https://doi.org/10.1016/j.ccr.2011.02.008.
- Chicago author-date (all authors)
- Homminga, Irene, Rob Pieters, Anton W Langerak, Johan J de Rooi, Andrew Stubbs, Monique Verstegen, Maartje Vuerhard, Jessica Buijs-Gladdines, Clarissa Kooi, Petra Klous, Pieter Van Vlierberghe, Adolfo A Ferrando, Jean Michel Cayuela, Brenda Verhaaf, H Berna Beverloo, Martin Horstmann, Valerie de Haas, Anna-Sophia Wiekmeijer, Karin Pike-Overzet, Frank JT Staal, Wouter de Laat, Jean Soulier, François Sigaux, and Jules PP Meijerink. 2011. “Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia.” CANCER CELL 19 (4): 484–497. doi:10.1016/j.ccr.2011.02.008.
- Vancouver
- 1.Homminga I, Pieters R, Langerak AW, de Rooi JJ, Stubbs A, Verstegen M, et al. Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. CANCER CELL. 2011;19(4):484–97.
- IEEE
- [1]I. Homminga et al., “Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia,” CANCER CELL, vol. 19, no. 4, pp. 484–497, 2011.
@article{3126508, abstract = {{To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed molecular-cytogenetic analyses including the Chromosome Conformation Capture on Chip (4C) method. Two T-ALL subtypes were identified that lacked rearrangements of known oncogenes. One subtype associated with cortical arrest, expression of cell cycle genes, and ectopic NKX2-1 or NKX2-2 expression for which rearrangements were identified. The second subtype associated with immature T cell development and high expression of the MEF2C transcription factor as consequence of rearrangements of MEF2C, transcription factors that target MEF2C, or MEF2C-associated cofactors. We propose NKX2-1, NKX2-2, and MEF2C as T-ALL oncogenes that are activated by various rearrangements.}}, author = {{Homminga, Irene and Pieters, Rob and Langerak, Anton W and de Rooi, Johan J and Stubbs, Andrew and Verstegen, Monique and Vuerhard, Maartje and Buijs-Gladdines, Jessica and Kooi, Clarissa and Klous, Petra and Van Vlierberghe, Pieter and Ferrando, Adolfo A and Cayuela, Jean Michel and Verhaaf, Brenda and Beverloo, H Berna and Horstmann, Martin and de Haas, Valerie and Wiekmeijer, Anna-Sophia and Pike-Overzet, Karin and Staal, Frank JT and de Laat, Wouter and Soulier, Jean and Sigaux, François and Meijerink, Jules PP}}, issn = {{1535-6108}}, journal = {{CANCER CELL}}, keywords = {{TARGET GENE,C-MYC,HOMEOBOX GENE,ACTIVATION MECHANISM,GENE-EXPRESSION,FUSION,CANCER,NOTCH1,IDENTIFICATION,TRANSFORMATION}}, language = {{eng}}, number = {{4}}, pages = {{484--497}}, title = {{Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia}}, url = {{http://doi.org/10.1016/j.ccr.2011.02.008}}, volume = {{19}}, year = {{2011}}, }
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