Advanced search

β-chemokine receptor expression in idiopathic inflammatory myopathies

Boel De Paepe (UGent) and Jan De Bleecker (UGent)
(2005) MUSCLE & NERVE. 31(5). p.621-627
Author
Organization
Abstract
beta-chemokines attract and activate T cells and monocytes and have a key role in chronic inflammation. Certain beta-chemokines, such as monocyte chemoattractant protein-1 (MCP-1), have been reported to be upregulated in the idiopathic inflammatory myopathies (IIM). We studied the distribution of beta-chemokine receptors in polymyositis (PM), sporadic inclusion-body myositis (sIBM), dermatomyositis (DIM), and control samples. CCR1-5 were localized to blood vessels in all samples. In addition, increased endothelial expression of CCR2A was observed in IIM. Subsets of inflammatory cells, identified as macrophages and T cells, in all three types of IN expressed CCR2A, CCR2B, CCR3, CCR4, and CCR5. In contrast to an earlier report, we found CCR2B to be the most prominent MCP-1 receptor on inflammatory cells in IIM, especially in PM and sIBM. Strong CCR4 expression was present on myonuclei of regenerating muscle fibers. The prominence of the CCR2 receptors further underlines the importance of the interaction with their ligand MCP-1 in the immunopathogenesis of IIM and puts CCR2B forward as a potential target for future therapeutic intervention.
Keywords
chemokines, idiopathic inflammatory myopathy, immunoblotting, immunofluorescence, inflammation, CHEMOATTRACTANT PROTEIN-1 RECEPTOR, CENTRAL-NERVOUS-SYSTEM, DIFFERENTIAL EXPRESSION, ARTHRITIS, ISOFORMS, MCP-1, CCR2, ANTAGONIST, REJECTION, RESPONSES

Citation

Please use this url to cite or link to this publication:

Chicago
De Paepe, Boel, and Jan De Bleecker. 2005. “Β-chemokine Receptor Expression in Idiopathic Inflammatory Myopathies.” Muscle & Nerve 31 (5): 621–627.
APA
De Paepe, Boel, & De Bleecker, J. (2005). β-chemokine receptor expression in idiopathic inflammatory myopathies. MUSCLE & NERVE, 31(5), 621–627. Presented at the 7th International congress of the World Muscle Society.
Vancouver
1.
De Paepe B, De Bleecker J. β-chemokine receptor expression in idiopathic inflammatory myopathies. MUSCLE & NERVE. 2005;31(5):621–7.
MLA
De Paepe, Boel, and Jan De Bleecker. “Β-chemokine Receptor Expression in Idiopathic Inflammatory Myopathies.” MUSCLE & NERVE 31.5 (2005): 621–627. Print.
@article{311610,
  abstract     = {beta-chemokines attract and activate T cells and monocytes and have a key role in chronic inflammation. Certain beta-chemokines, such as monocyte chemoattractant protein-1 (MCP-1), have been reported to be upregulated in the idiopathic inflammatory myopathies (IIM). We studied the distribution of beta-chemokine receptors in polymyositis (PM), sporadic inclusion-body myositis (sIBM), dermatomyositis (DIM), and control samples. CCR1-5 were localized to blood vessels in all samples. In addition, increased endothelial expression of CCR2A was observed in IIM. Subsets of inflammatory cells, identified as macrophages and T cells, in all three types of IN expressed CCR2A, CCR2B, CCR3, CCR4, and CCR5. In contrast to an earlier report, we found CCR2B to be the most prominent MCP-1 receptor on inflammatory cells in IIM, especially in PM and sIBM. Strong CCR4 expression was present on myonuclei of regenerating muscle fibers. The prominence of the CCR2 receptors further underlines the importance of the interaction with their ligand MCP-1 in the immunopathogenesis of IIM and puts CCR2B forward as a potential target for future therapeutic intervention.},
  author       = {De Paepe, Boel and De Bleecker, Jan},
  issn         = {0148-639X},
  journal      = {MUSCLE & NERVE},
  keywords     = {chemokines,idiopathic inflammatory myopathy,immunoblotting,immunofluorescence,inflammation,CHEMOATTRACTANT PROTEIN-1 RECEPTOR,CENTRAL-NERVOUS-SYSTEM,DIFFERENTIAL EXPRESSION,ARTHRITIS,ISOFORMS,MCP-1,CCR2,ANTAGONIST,REJECTION,RESPONSES},
  language     = {eng},
  location     = {Rotterdam, The Netherlands},
  number       = {5},
  pages        = {621--627},
  title        = {β-chemokine receptor expression in idiopathic inflammatory myopathies},
  volume       = {31},
  year         = {2005},
}

Web of Science
Times cited: