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The use of cardiac biomarkers in veterinary medicine: the equine perspective

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Abstract
In human medicine, cardiac biomarkers, such as natriuretic peptides and troponins, are routinely used for the diagnosis, prognosis and monitoring of heart diseases. Similarly, these biomarkers are determined in small animals to differentiate non-cardiac from cardiac diseases. Knowledge about these biomarkers in horses is limited and requires further investigation. The first equine studies about atrial natriuretic peptide (ANP) and N-terminal ANP (NT-proANP) are promising, and show a clear correlation with atrial dimension size. Equine brain natriuretic peptides assays are still unavailable. The troponins, in particular troponin I, have been more extensively studied in horses, and their use for the diagnosis of myocardial damage has been fully demonstrated. They have replaced the less specific lactate dehydrogenase and creatine kinase isoenzymes, which makes the use of the last mentioned no longer legitimate. A final possible equine biomarker is aldosterone. Reference values in horses have been established. However, in only one study, a correlation between aldosterone and cardiac disease has been reported.
Keywords
CONGESTIVE-HEART-FAILURE, ATRIAL-NATRIURETIC-PEPTIDE, TROPONIN-I CONCENTRATION, MITRAL-VALVE DISEASE, SKELETAL-MUSCLE, ENDOCRINE HEART, PLASMA, HORSES, DOGS, ALDOSTERONE

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Citation

Please use this url to cite or link to this publication:

Chicago
Van Der Vekens, Nicky, Annelies Decloedt, Dominique De Clercq, Tinne Verheyen, and Gunther van Loon. 2012. “The Use of Cardiac Biomarkers in Veterinary Medicine: The Equine Perspective.” Vlaams Diergeneeskundig Tijdschrift 81 (6): 319–327.
APA
Van Der Vekens, N., Decloedt, A., De Clercq, D., Verheyen, T., & van Loon, G. (2012). The use of cardiac biomarkers in veterinary medicine: the equine perspective. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 81(6), 319–327.
Vancouver
1.
Van Der Vekens N, Decloedt A, De Clercq D, Verheyen T, van Loon G. The use of cardiac biomarkers in veterinary medicine: the equine perspective. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2012;81(6):319–27.
MLA
Van Der Vekens, Nicky, Annelies Decloedt, Dominique De Clercq, et al. “The Use of Cardiac Biomarkers in Veterinary Medicine: The Equine Perspective.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 81.6 (2012): 319–327. Print.
@article{3107392,
  abstract     = {In human medicine, cardiac biomarkers, such as natriuretic peptides and troponins, are routinely used for the diagnosis, prognosis and monitoring of heart diseases. Similarly, these biomarkers are determined in small animals to differentiate non-cardiac from cardiac diseases. Knowledge about these biomarkers in horses is limited and requires further investigation. The first equine studies about atrial natriuretic peptide (ANP) and N-terminal ANP (NT-proANP) are promising, and show a clear correlation with atrial dimension size. Equine brain natriuretic peptides assays are still unavailable. The troponins, in particular troponin I, have been more extensively studied in horses, and their use for the diagnosis of myocardial damage has been fully demonstrated. They have replaced the less specific lactate dehydrogenase and creatine kinase isoenzymes, which makes the use of the last mentioned no longer legitimate. A final possible equine biomarker is aldosterone. Reference values in horses have been established. However, in only one study, a correlation between aldosterone and cardiac disease has been reported.},
  author       = {Van Der Vekens, Nicky and Decloedt, Annelies and De Clercq, Dominique and Verheyen, Tinne and van Loon, Gunther},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  language     = {eng},
  number       = {6},
  pages        = {319--327},
  title        = {The use of cardiac biomarkers in veterinary medicine: the equine perspective},
  volume       = {81},
  year         = {2012},
}

Web of Science
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