How do 'housekeeping' genes control organogenesis?: unexpected new findings on the role of housekeeping genes in cell and organ differentiation
- Author
- Hirokazu Tsukaya, Mary E Byrne, Gorou Horiguchi, Munetaka Sugiyama, Maria Van Lijsebettens (UGent) and Michael Lenhard
- Organization
- Abstract
- In recent years, an increasing number of mutations in what would appear to be 'housekeeping genes' have been identified as having unexpectedly specific defects in multicellular organogenesis. This is also the case for organogenesis in seed plants. Although it is not surprising that loss-of-function mutations in 'housekeeping' genes result in lethality or growth retardation, it is surprising when (1) the mutant phenotype results from the loss of function of a 'housekeeping' gene and (2) the mutant phenotype is specific. In this review, by defining housekeeping genes as those encoding proteins that work in basic metabolic and cellular functions, we discuss unexpected links between housekeeping genes and specific developmental processes. In a surprising number of cases housekeeping genes coding for enzymes or proteins with functions in basic cellular processes such as transcription, post-transcriptional modification, and translation affect plant development.
- Keywords
- Transcription, LEAF ADAXIAL IDENTITY, Translation, 3 '-end processing, Ribosome, Pre-mRNA splicing, RNAPII, Post-transcriptional modification, Housekeeping genes, Development, POLYADENYLATION FACTOR SUBUNIT, AFFECTS PLANT DEVELOPMENT, SEMI-DOMINANT MUTATION, FLOWERING-LOCUS-C, ARABIDOPSIS-THALIANA, RIBOSOMAL-PROTEINS, TRANSLATION REINITIATION, REPRODUCTIVE DEVELOPMENT, ASYMMETRIC-LEAVES2 GENE
Downloads
-
(...).pdf
- full text
- |
- UGent only
- |
- |
- 368.59 KB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-3107063
- MLA
- Tsukaya, Hirokazu, et al. “How Do ‘housekeeping’ Genes Control Organogenesis?: Unexpected New Findings on the Role of Housekeeping Genes in Cell and Organ Differentiation.” JOURNAL OF PLANT RESEARCH, vol. 126, no. 1, 2013, pp. 3–15, doi:10.1007/s10265-012-0518-2.
- APA
- Tsukaya, H., Byrne, M. E., Horiguchi, G., Sugiyama, M., Van Lijsebettens, M., & Lenhard, M. (2013). How do “housekeeping” genes control organogenesis?: unexpected new findings on the role of housekeeping genes in cell and organ differentiation. JOURNAL OF PLANT RESEARCH, 126(1), 3–15. https://doi.org/10.1007/s10265-012-0518-2
- Chicago author-date
- Tsukaya, Hirokazu, Mary E Byrne, Gorou Horiguchi, Munetaka Sugiyama, Maria Van Lijsebettens, and Michael Lenhard. 2013. “How Do ‘housekeeping’ Genes Control Organogenesis?: Unexpected New Findings on the Role of Housekeeping Genes in Cell and Organ Differentiation.” JOURNAL OF PLANT RESEARCH 126 (1): 3–15. https://doi.org/10.1007/s10265-012-0518-2.
- Chicago author-date (all authors)
- Tsukaya, Hirokazu, Mary E Byrne, Gorou Horiguchi, Munetaka Sugiyama, Maria Van Lijsebettens, and Michael Lenhard. 2013. “How Do ‘housekeeping’ Genes Control Organogenesis?: Unexpected New Findings on the Role of Housekeeping Genes in Cell and Organ Differentiation.” JOURNAL OF PLANT RESEARCH 126 (1): 3–15. doi:10.1007/s10265-012-0518-2.
- Vancouver
- 1.Tsukaya H, Byrne ME, Horiguchi G, Sugiyama M, Van Lijsebettens M, Lenhard M. How do “housekeeping” genes control organogenesis?: unexpected new findings on the role of housekeeping genes in cell and organ differentiation. JOURNAL OF PLANT RESEARCH. 2013;126(1):3–15.
- IEEE
- [1]H. Tsukaya, M. E. Byrne, G. Horiguchi, M. Sugiyama, M. Van Lijsebettens, and M. Lenhard, “How do ‘housekeeping’ genes control organogenesis?: unexpected new findings on the role of housekeeping genes in cell and organ differentiation,” JOURNAL OF PLANT RESEARCH, vol. 126, no. 1, pp. 3–15, 2013.
@article{3107063, abstract = {{In recent years, an increasing number of mutations in what would appear to be 'housekeeping genes' have been identified as having unexpectedly specific defects in multicellular organogenesis. This is also the case for organogenesis in seed plants. Although it is not surprising that loss-of-function mutations in 'housekeeping' genes result in lethality or growth retardation, it is surprising when (1) the mutant phenotype results from the loss of function of a 'housekeeping' gene and (2) the mutant phenotype is specific. In this review, by defining housekeeping genes as those encoding proteins that work in basic metabolic and cellular functions, we discuss unexpected links between housekeeping genes and specific developmental processes. In a surprising number of cases housekeeping genes coding for enzymes or proteins with functions in basic cellular processes such as transcription, post-transcriptional modification, and translation affect plant development.}}, author = {{Tsukaya, Hirokazu and Byrne, Mary E and Horiguchi, Gorou and Sugiyama, Munetaka and Van Lijsebettens, Maria and Lenhard, Michael}}, issn = {{0918-9440}}, journal = {{JOURNAL OF PLANT RESEARCH}}, keywords = {{Transcription,LEAF ADAXIAL IDENTITY,Translation,3 '-end processing,Ribosome,Pre-mRNA splicing,RNAPII,Post-transcriptional modification,Housekeeping genes,Development,POLYADENYLATION FACTOR SUBUNIT,AFFECTS PLANT DEVELOPMENT,SEMI-DOMINANT MUTATION,FLOWERING-LOCUS-C,ARABIDOPSIS-THALIANA,RIBOSOMAL-PROTEINS,TRANSLATION REINITIATION,REPRODUCTIVE DEVELOPMENT,ASYMMETRIC-LEAVES2 GENE}}, language = {{eng}}, number = {{1}}, pages = {{3--15}}, title = {{How do 'housekeeping' genes control organogenesis?: unexpected new findings on the role of housekeeping genes in cell and organ differentiation}}, url = {{http://doi.org/10.1007/s10265-012-0518-2}}, volume = {{126}}, year = {{2013}}, }
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: