Ghent University Academic Bibliography

Advanced

Automatic generation of a plan optimization volume for tangential field breast cancer radiation therapy

Koen Van Vaerenbergh, Werner De Gersem UGent, Luc Vakaet UGent, MARC COGHE, Tom Boterberg UGent, MARIE-ELISABETH BAKKER, CRISTINA DERIE, WOUTER WILLAERT, Patricia Seij, WIM DUTHOY, et al. (2005) STRAHLENTHERAPIE UND ONKOLOGIE. 181(2). p.82-88
abstract
Background and Purpose: Dose homogeneity is one of the objectives during computer planning of postoperative radiotherapy of the conserved breast. For three-dimensional (3-D) optimization of the dose distribution using serial CT scan images, suitable volumes have to be delineated. The purpose of this study was to develop a computer-generated delineation of a plan optimization volume (POV) and an irradiated volume (IV) and to automate their use in a fast dose homogeneity optimization engine. Patients and Methods: Simulation was performed according to our standard procedure which involves the positioning of a lead collar around the palpable breast to facilitate the definition of gantry angle, collimator angle and field aperture for tangential wedged photon beams. In a change to the standard procedure an anterolateral radiograph was taken with its axis orthogonal to the central plane of the two tangential half-beams. Images from a serial CT scan were acquired in treatment position, and the geometric data of the three simulated beams were used by a computer program to generate the POV and IV. For each patient, weights of wedged and unwedged beams were optimized by either human heuristics using only the central slice (2-D), the whole set of CT slices (3-D), or by a computer algorithm using the POV, IV and Lung volume with constrained matrix inversion (CMI) as optimization method. The resulting dose distributions were compared. Results: The total planning procedure took, on average, 44 min of which < 7 min were needed for human interactions, compared to about 52 min for the standard planning at Ghent University Hospital, Belgium. The simulation time is increased by 2-3 min. The method provides 3-D information of the dose distribution. Dose homogeneity and minimum dose inside the POV and maximum dose inside the IV were not significantly different for the three optimization techniques. Conclusion: This automated planning method is capable of replacing the contouring of the clinical target volume as well as the trial-and-error procedure of assigning weights of wedged and unwedged beams by an experienced planner.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
automated generation, breast cancer, plan optimization, INTENSITY-MODULATED RADIOTHERAPY, INTACT BREAST, CONFORMAL RADIOTHERAPY, IRRADIATION, IMRT, ELECTRON, DELIVERY
journal title
STRAHLENTHERAPIE UND ONKOLOGIE
Strahlenther. Onkol.
volume
181
issue
2
pages
82 - 88
Web of Science type
Article
Web of Science id
000227775900003
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
3.49 (2005)
JCR rank
11/84 (2005)
JCR quartile
1 (2005)
ISSN
0179-7158
DOI
10.1007/s00066-005-1310-1
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
310660
handle
http://hdl.handle.net/1854/LU-310660
date created
2005-06-03 14:18:00
date last changed
2016-12-19 15:42:30
@article{310660,
  abstract     = {Background and Purpose: Dose homogeneity is one of the objectives during computer planning of postoperative radiotherapy of the conserved breast. For three-dimensional (3-D) optimization of the dose distribution using serial CT scan images, suitable volumes have to be delineated. The purpose of this study was to develop a computer-generated delineation of a plan optimization volume (POV) and an irradiated volume (IV) and to automate their use in a fast dose homogeneity optimization engine. 
Patients and Methods: Simulation was performed according to our standard procedure which involves the positioning of a lead collar around the palpable breast to facilitate the definition of gantry angle, collimator angle and field aperture for tangential wedged photon beams. In a change to the standard procedure an anterolateral radiograph was taken with its axis orthogonal to the central plane of the two tangential half-beams. Images from a serial CT scan were acquired in treatment position, and the geometric data of the three simulated beams were used by a computer program to generate the POV and IV. For each patient, weights of wedged and unwedged beams were optimized by either human heuristics using only the central slice (2-D), the whole set of CT slices (3-D), or by a computer algorithm using the POV, IV and Lung volume with constrained matrix inversion (CMI) as optimization method. The resulting dose distributions were compared. 
Results: The total planning procedure took, on average, 44 min of which {\textlangle} 7 min were needed for human interactions, compared to about 52 min for the standard planning at Ghent University Hospital, Belgium. The simulation time is increased by 2-3 min. The method provides 3-D information of the dose distribution. Dose homogeneity and minimum dose inside the POV and maximum dose inside the IV were not significantly different for the three optimization techniques. 
Conclusion: This automated planning method is capable of replacing the contouring of the clinical target volume as well as the trial-and-error procedure of assigning weights of wedged and unwedged beams by an experienced planner.},
  author       = {Van Vaerenbergh, Koen and De Gersem, Werner and Vakaet, Luc and COGHE, MARC and Boterberg, Tom and BAKKER, MARIE-ELISABETH and DERIE, CRISTINA and WILLAERT, WOUTER and Seij, Patricia and DUTHOY, WIM and De Wagter, Carlos and De Neve, Wilfried},
  issn         = {0179-7158},
  journal      = {STRAHLENTHERAPIE UND ONKOLOGIE},
  keyword      = {automated generation,breast cancer,plan optimization,INTENSITY-MODULATED RADIOTHERAPY,INTACT BREAST,CONFORMAL RADIOTHERAPY,IRRADIATION,IMRT,ELECTRON,DELIVERY},
  language     = {eng},
  number       = {2},
  pages        = {82--88},
  title        = {Automatic generation of a plan optimization volume for tangential field breast cancer radiation therapy},
  url          = {http://dx.doi.org/10.1007/s00066-005-1310-1},
  volume       = {181},
  year         = {2005},
}

Chicago
Van Vaerenbergh, Koen, Werner De Gersem, Luc Vakaet, MARC COGHE, Tom Boterberg, MARIE-ELISABETH BAKKER, CRISTINA DERIE, et al. 2005. “Automatic Generation of a Plan Optimization Volume for Tangential Field Breast Cancer Radiation Therapy.” Strahlentherapie Und Onkologie 181 (2): 82–88.
APA
Van Vaerenbergh, K., De Gersem, W., Vakaet, L., COGHE, M., Boterberg, T., BAKKER, M.-E., DERIE, C., et al. (2005). Automatic generation of a plan optimization volume for tangential field breast cancer radiation therapy. STRAHLENTHERAPIE UND ONKOLOGIE, 181(2), 82–88.
Vancouver
1.
Van Vaerenbergh K, De Gersem W, Vakaet L, COGHE M, Boterberg T, BAKKER M-E, et al. Automatic generation of a plan optimization volume for tangential field breast cancer radiation therapy. STRAHLENTHERAPIE UND ONKOLOGIE. 2005;181(2):82–8.
MLA
Van Vaerenbergh, Koen, Werner De Gersem, Luc Vakaet, et al. “Automatic Generation of a Plan Optimization Volume for Tangential Field Breast Cancer Radiation Therapy.” STRAHLENTHERAPIE UND ONKOLOGIE 181.2 (2005): 82–88. Print.