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Chlamydial biology and its associated virulence blockers

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Abstract
Chlamydiales are obligate intracellular parasites of eukaryotic cells. They can be distinguished from other Gram-negative bacteria through their characteristic developmental cycle, in addition to special biochemical and physical adaptations to subvert the eukaryotic host cell. The host spectrum includes humans and other mammals, fish, birds, reptiles, insects and even amoeba, causing a plethora of diseases. The first part of this review focuses on the specific chlamydial infection biology and metabolism. As resistance to classical antibiotics is emerging among Chlamydiae as well, the second part elaborates on specific compounds and tools to block chlamydial virulence traits, such as adhesion and internalization, Type III secretion and modulation of gene expression.
Keywords
infection biology, chlamydia, Antibiotic resistance, virulence, OUTER-MEMBRANE PROTEIN, virulence blockers, III SECRETION SYSTEM, QUORUM-SENSING INHIBITORS, GRAM-NEGATIVE BACTERIA, HUMAN EPITHELIAL-CELLS, NUCLEOTIDE TRANSPORT PROTEINS, TARGETING BACTERIAL VIRULENCE, SPONGE CAMINUS-SPHAEROCONIA, TRACHOMATIS OMCB PROTEIN, SMALL-MOLECULE INHIBITORS

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Chicago
Beeckman, Delphine Sylvie Anne, Leentje De Puysseleyr, Kristien De Puysseleyr, and Daisy Vanrompay. 2014. “Chlamydial Biology and Its Associated Virulence Blockers.” Critical Reviews in Microbiology 40 (4): 313–328.
APA
Beeckman, D. S. A., De Puysseleyr, L., De Puysseleyr, K., & Vanrompay, D. (2014). Chlamydial biology and its associated virulence blockers. CRITICAL REVIEWS IN MICROBIOLOGY, 40(4), 313–328.
Vancouver
1.
Beeckman DSA, De Puysseleyr L, De Puysseleyr K, Vanrompay D. Chlamydial biology and its associated virulence blockers. CRITICAL REVIEWS IN MICROBIOLOGY. 2014;40(4):313–28.
MLA
Beeckman, Delphine Sylvie Anne, Leentje De Puysseleyr, Kristien De Puysseleyr, et al. “Chlamydial Biology and Its Associated Virulence Blockers.” CRITICAL REVIEWS IN MICROBIOLOGY 40.4 (2014): 313–328. Print.
@article{3105451,
  abstract     = {Chlamydiales are obligate intracellular parasites of eukaryotic cells. They can be distinguished from other Gram-negative bacteria through their characteristic developmental cycle, in addition to special biochemical and physical adaptations to subvert the eukaryotic host cell. The host spectrum includes humans and other mammals, fish, birds, reptiles, insects and even amoeba, causing a plethora of diseases. The first part of this review focuses on the specific chlamydial infection biology and metabolism. As resistance to classical antibiotics is emerging among Chlamydiae as well, the second part elaborates on specific compounds and tools to block chlamydial virulence traits, such as adhesion and internalization, Type III secretion and modulation of gene expression.},
  author       = {Beeckman, Delphine Sylvie Anne and De Puysseleyr, Leentje and De Puysseleyr, Kristien and Vanrompay, Daisy},
  issn         = {1040-841X},
  journal      = {CRITICAL REVIEWS IN MICROBIOLOGY},
  keywords     = {infection biology,chlamydia,Antibiotic resistance,virulence,OUTER-MEMBRANE PROTEIN,virulence blockers,III SECRETION SYSTEM,QUORUM-SENSING INHIBITORS,GRAM-NEGATIVE BACTERIA,HUMAN EPITHELIAL-CELLS,NUCLEOTIDE TRANSPORT PROTEINS,TARGETING BACTERIAL VIRULENCE,SPONGE CAMINUS-SPHAEROCONIA,TRACHOMATIS OMCB PROTEIN,SMALL-MOLECULE INHIBITORS},
  language     = {eng},
  number       = {4},
  pages        = {313--328},
  title        = {Chlamydial biology and its associated virulence blockers},
  url          = {http://dx.doi.org/10.3109/1040841X.2012.726210},
  volume       = {40},
  year         = {2014},
}

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