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Dietary fat and the human gut microbiome

(2013)
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Abstract
The aim of this doctoral work was to investigate the effect of an increased level of fat in the Western diet on the composition and metabolic activity of the colon microbiota. Specific interest thereby went to two ‘fatty’ compounds: glycerol and the omega-6 polyunsaturated fatty acid linoleic acid. In vitro experiments were performed with various models of the human gut microbiota. In addition, a model of the colon epithelium was used to study the effect of glycerol fermentation on infection by Salmonella. Using these models, it was demonstrated that glycerol and linoleic acid may significantly impact microbial processes and species that are associated with human health. Glycerol fermentation was found to protect against pathogenic infection, while high levels of linoleic acid were considered a threat for the prevalence and activity of beneficial microbes. These detrimental effects were dependent on the presence of a simulated mucus layer. Overall, the results of this doctoral research demonstrate that an increased delivery of fat to the colon may significantly impact health-related microbial processes. These novel findings underpin the need for further in vivo research concerning the impact of colonic fat for human health.
Keywords
colon, Salmonella, Lactobacillus reuteri, gut bacteria, PUFA, linoleic acid, reuterin, glycerol, fat, mucus, host-microbe interaction, gut epithelium, infection

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Citation

Please use this url to cite or link to this publication:

MLA
De Weirdt, Rosemarie. Dietary Fat and the Human Gut Microbiome. Ghent University. Faculty of Bioscience Engineering, 2013.
APA
De Weirdt, R. (2013). Dietary fat and the human gut microbiome. Ghent University. Faculty of Bioscience Engineering, Ghent, Belgium.
Chicago author-date
De Weirdt, Rosemarie. 2013. “Dietary Fat and the Human Gut Microbiome.” Ghent, Belgium: Ghent University. Faculty of Bioscience Engineering.
Chicago author-date (all authors)
De Weirdt, Rosemarie. 2013. “Dietary Fat and the Human Gut Microbiome.” Ghent, Belgium: Ghent University. Faculty of Bioscience Engineering.
Vancouver
1.
De Weirdt R. Dietary fat and the human gut microbiome. [Ghent, Belgium]: Ghent University. Faculty of Bioscience Engineering; 2013.
IEEE
[1]
R. De Weirdt, “Dietary fat and the human gut microbiome,” Ghent University. Faculty of Bioscience Engineering, Ghent, Belgium, 2013.
@phdthesis{3103895,
  abstract     = {{The aim of this doctoral work was to investigate the effect of an increased level of fat in the Western diet on the composition and metabolic activity of the colon microbiota. Specific interest thereby went to two ‘fatty’ compounds: glycerol and the omega-6 polyunsaturated fatty acid linoleic acid. In vitro experiments were performed with various models of the human gut microbiota. In addition, a model of the colon epithelium was used to study the effect of glycerol fermentation on infection by Salmonella. Using these models, it was demonstrated that glycerol and linoleic acid may significantly impact microbial processes and species that are associated with human health. Glycerol fermentation was found to protect against pathogenic infection, while high levels of linoleic acid were considered a threat for the prevalence and activity of beneficial microbes. These detrimental effects were dependent on the presence of a simulated mucus layer. 
Overall, the results of this doctoral research demonstrate that an increased delivery of fat to the colon may significantly impact health-related microbial processes. These novel findings underpin the need for further in vivo research concerning the impact of colonic fat for human health.}},
  author       = {{De Weirdt, Rosemarie}},
  isbn         = {{9789059895867}},
  keywords     = {{colon,Salmonella,Lactobacillus reuteri,gut bacteria,PUFA,linoleic acid,reuterin,glycerol,fat,mucus,host-microbe interaction,gut epithelium,infection}},
  language     = {{eng}},
  pages        = {{VII, 183}},
  publisher    = {{Ghent University. Faculty of Bioscience Engineering}},
  school       = {{Ghent University}},
  title        = {{Dietary fat and the human gut microbiome}},
  year         = {{2013}},
}