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Prediction of postoperative seizure control by hippocampal event-related potentials

(1999) EPILEPSIA. 40(3). p.303-306
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Abstract
Purpose: In spite of unequivocal results of the pre-surgical evaluation, between 10 and 30% of patients with medial temporal lobe epilepsy (MTLE) do not become seizure free by temporal lobe surgery. Because event-related potentials (ERPs) recorded within the hippocampal formation have been shown to be sensitive to the epileptogenic process, we examined whether ERPs can help to improve the prediction of postoperative seizure control. Methods: We recorded ERPs to words from bilateral intra-hippocampal electrodes by using a visual word-recognition paradigm in 70 patients with unilateral hippocampal pathology and related these measurements to seizure outcome after temporal lobe surgery. Results: Words elicited N400 potentials, which were reduced in amplitude on repetition on the side contralateral to hippocampal sclerosis. This contralateral repetition effect, however, was significantly diminished in the group of patients who experienced seizure recurrence after the operation. Contralateral repetition effects thus permitted correct prediction of postoperative seizure control in 94% of all patients. Conclusions: Recording ERPs to words within the medial temporal lobes can improve the prediction of postoperative seizure control. Reduced repetition effects contralateral to the side of hippocampal sclerosis may indicate bilateral epileptogenicity.
Keywords
outcome, hippocampus, surgery, temporal lobe epilepsy, event-related potentials, TEMPORAL-LOBE EPILEPSY, EMISSION COMPUTED-TOMOGRAPHY, EEG, MEMORY, LOCALIZATION, PATTERNS, ATROPHY, SURGERY, FOCUS

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Chicago
Grunwald, Thomas, Klaus Lehnertz, Nico Pezer, Martin Kurthen, Dirk Van Roost, Johannes Schramm, and Christian E Elger. 1999. “Prediction of Postoperative Seizure Control by Hippocampal Event-related Potentials.” Epilepsia 40 (3): 303–306.
APA
Grunwald, T., Lehnertz, K., Pezer, N., Kurthen, M., Van Roost, D., Schramm, J., & Elger, C. E. (1999). Prediction of postoperative seizure control by hippocampal event-related potentials. EPILEPSIA, 40(3), 303–306.
Vancouver
1.
Grunwald T, Lehnertz K, Pezer N, Kurthen M, Van Roost D, Schramm J, et al. Prediction of postoperative seizure control by hippocampal event-related potentials. EPILEPSIA. 1999;40(3):303–6.
MLA
Grunwald, Thomas, Klaus Lehnertz, Nico Pezer, et al. “Prediction of Postoperative Seizure Control by Hippocampal Event-related Potentials.” EPILEPSIA 40.3 (1999): 303–306. Print.
@article{3100911,
  abstract     = {Purpose: In spite of unequivocal results of the pre-surgical evaluation, between 10 and 30% of patients with medial temporal lobe epilepsy (MTLE) do not become seizure free by temporal lobe surgery. Because event-related potentials (ERPs) recorded within the hippocampal formation have been shown to be sensitive to the epileptogenic process, we examined whether ERPs can help to improve the prediction of postoperative seizure control. 
Methods: We recorded ERPs to words from bilateral intra-hippocampal electrodes by using a visual word-recognition paradigm in 70 patients with unilateral hippocampal pathology and related these measurements to seizure outcome after temporal lobe surgery. 
Results: Words elicited N400 potentials, which were reduced in amplitude on repetition on the side contralateral to hippocampal sclerosis. This contralateral repetition effect, however, was significantly diminished in the group of patients who experienced seizure recurrence after the operation. Contralateral repetition effects thus permitted correct prediction of postoperative seizure control in 94% of all patients. 
Conclusions: Recording ERPs to words within the medial temporal lobes can improve the prediction of postoperative seizure control. Reduced repetition effects contralateral to the side of hippocampal sclerosis may indicate bilateral epileptogenicity.},
  author       = {Grunwald, Thomas and Lehnertz, Klaus and Pezer, Nico and Kurthen, Martin and Van Roost, Dirk and Schramm, Johannes and Elger, Christian E},
  issn         = {0013-9580},
  journal      = {EPILEPSIA},
  keywords     = {outcome,hippocampus,surgery,temporal lobe epilepsy,event-related potentials,TEMPORAL-LOBE EPILEPSY,EMISSION COMPUTED-TOMOGRAPHY,EEG,MEMORY,LOCALIZATION,PATTERNS,ATROPHY,SURGERY,FOCUS},
  language     = {eng},
  number       = {3},
  pages        = {303--306},
  title        = {Prediction of postoperative seizure control by hippocampal event-related potentials},
  url          = {http://dx.doi.org/10.1111/j.1528-1157.1999.tb00708.x},
  volume       = {40},
  year         = {1999},
}

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