Advanced search
1 file | 363.21 KB

Limbic P300s in temporal lobe epilepsy with and without Ammon's horn sclerosis

(1999) EUROPEAN JOURNAL OF NEUROSCIENCE. 11(6). p.1899-1906
Author
Organization
Abstract
Limbic P300 potentials can be recorded within the mesial temporal robes of patients with temporal lobe epilepsy (TLE). To delineate possible mechanisms of their generation and pathological alteration, we analysed limbic P300s in 55 TLE patients with and 29 without Ammon's horn sclerosis (AHS) and correlated their amplitudes with neuronal cell counts in 30 histopathological specimens. Limbic P300 amplitudes were reduced on the side of the epileptogenic focus only in patients with AHS. Moreover, in AHS patients, limbic P300 latencies were prolonged bilaterally; and in patients with left-sided AHS, amplitudes were reduced bilaterally. Both findings suggest bilateral functional deficits in TLE with unilateral AHS. Limbic P300 areas correlated significantly with neuronal densities of dentate gyrus granule cells but not hippocampal pyramidal cells in the CA1-4 (cornu ammonia) subfields. This finding points to a potential mechanism for the bilateral effects of unilateral AHS as both dentate gyri exhibit strong reciprocal contralateral connectivity.
Keywords
P300 species : humans, temporal lobe epilepsy, hippocampus, event-related potentials, HUMAN HIPPOCAMPAL-FORMATION, EVENT-RELATED POTENTIALS, INTRACEREBRAL POTENTIALS, VISUAL-STIMULI, DENTATE GYRUS, RARE TARGET, PRESURGICAL EVALUATION, COGNITIVE POTENTIALS, SURGICAL PATHOLOGY, BASKET CELLS

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 363.21 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Grunwald, Thomas, Heinz Beck, Klaus Lehnertz, Ingmar Blümcke, Nico Pezer, Marta Kutas, Martin Kurthen, et al. 1999. “Limbic P300s in Temporal Lobe Epilepsy with and Without Ammon’s Horn Sclerosis.” European Journal of Neuroscience 11 (6): 1899–1906.
APA
Grunwald, T., Beck, H., Lehnertz, K., Blümcke, I., Pezer, N., Kutas, M., Kurthen, M., et al. (1999). Limbic P300s in temporal lobe epilepsy with and without Ammon’s horn sclerosis. EUROPEAN JOURNAL OF NEUROSCIENCE, 11(6), 1899–1906.
Vancouver
1.
Grunwald T, Beck H, Lehnertz K, Blümcke I, Pezer N, Kutas M, et al. Limbic P300s in temporal lobe epilepsy with and without Ammon’s horn sclerosis. EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(6):1899–906.
MLA
Grunwald, Thomas, Heinz Beck, Klaus Lehnertz, et al. “Limbic P300s in Temporal Lobe Epilepsy with and Without Ammon’s Horn Sclerosis.” EUROPEAN JOURNAL OF NEUROSCIENCE 11.6 (1999): 1899–1906. Print.
@article{3100874,
  abstract     = {Limbic P300 potentials can be recorded within the mesial temporal robes of patients with temporal lobe epilepsy (TLE). To delineate possible mechanisms of their generation and pathological alteration, we analysed limbic P300s in 55 TLE patients with and 29 without Ammon's horn sclerosis (AHS) and correlated their amplitudes with neuronal cell counts in 30 histopathological specimens. Limbic P300 amplitudes were reduced on the side of the epileptogenic focus only in patients with AHS. Moreover, in AHS patients, limbic P300 latencies were prolonged bilaterally; and in patients with left-sided AHS, amplitudes were reduced bilaterally. Both findings suggest bilateral functional deficits in TLE with unilateral AHS. Limbic P300 areas correlated significantly with neuronal densities of dentate gyrus granule cells but not hippocampal pyramidal cells in the CA1-4 (cornu ammonia) subfields. This finding points to a potential mechanism for the bilateral effects of unilateral AHS as both dentate gyri exhibit strong reciprocal contralateral connectivity.},
  author       = {Grunwald, Thomas and Beck, Heinz and Lehnertz, Klaus and Blümcke, Ingmar and Pezer, Nico and Kutas, Marta and Kurthen, Martin and Karakas, HM and Van Roost, Dirk and Wiestler, Otmar D and Elger, Christian E},
  issn         = {0953-816X},
  journal      = {EUROPEAN JOURNAL OF NEUROSCIENCE},
  keywords     = {P300 species : humans,temporal lobe epilepsy,hippocampus,event-related potentials,HUMAN HIPPOCAMPAL-FORMATION,EVENT-RELATED POTENTIALS,INTRACEREBRAL POTENTIALS,VISUAL-STIMULI,DENTATE GYRUS,RARE TARGET,PRESURGICAL EVALUATION,COGNITIVE POTENTIALS,SURGICAL PATHOLOGY,BASKET CELLS},
  language     = {eng},
  number       = {6},
  pages        = {1899--1906},
  title        = {Limbic P300s in temporal lobe epilepsy with and without Ammon's horn sclerosis},
  url          = {http://dx.doi.org/10.1046/j.1460-9568.1999.00613.x},
  volume       = {11},
  year         = {1999},
}

Altmetric
View in Altmetric
Web of Science
Times cited: