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Lymphocytic hypophysitis: non-invasive diagnosis and treatment by high dose methylprednisolone pulse therapy?

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Abstract
Criteria for the non-invasive diagnosis of lymphocytic hypophysitis (LyHy) and the results of the first prospective trial of high dose methylprednisolone pulse therapy (HDMPT) in nine patients are presented. In three patients, the diagnosis was established histologically, and in the others by clinical and endocrinological assessment, MRI, CSF examination, and measurement of thyroglobulin autoantibody concentration. After HDMPT, adenopituitary function improved in four of the nine patients and diabetes insipidus ceased or improved in all four concerned patients. The MRI findings improved in seven patients. LyHy has to be considered in the differential diagnosis of sellar lesions. The presumptive non-invasive diagnosis of LyHy seems possible in a high proportion of patients. HDMPT may result in the improvement of clinical, endocrinological, and MRI findings.
Keywords
pulse therapy, HYPOPITUITARISM, high dose methylprednisolone, lymphocytic hypophysitis, INVOLVEMENT, PITUITARY, CAVERNOUS SINUS

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Chicago
Kristof, Rudolf A, Dirk Van Roost, Dietrich Klingmüller, Wolfram Springer, and Johannes Schramm. 1999. “Lymphocytic Hypophysitis: Non-invasive Diagnosis and Treatment by High Dose Methylprednisolone Pulse Therapy?” Journal of Neurology Neurosurgery and Psychiatry 67 (3): 398–402.
APA
Kristof, R. A., Van Roost, D., Klingmüller, D., Springer, W., & Schramm, J. (1999). Lymphocytic hypophysitis: non-invasive diagnosis and treatment by high dose methylprednisolone pulse therapy? JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 67(3), 398–402.
Vancouver
1.
Kristof RA, Van Roost D, Klingmüller D, Springer W, Schramm J. Lymphocytic hypophysitis: non-invasive diagnosis and treatment by high dose methylprednisolone pulse therapy? JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 1999;67(3):398–402.
MLA
Kristof, Rudolf A, Dirk Van Roost, Dietrich Klingmüller, et al. “Lymphocytic Hypophysitis: Non-invasive Diagnosis and Treatment by High Dose Methylprednisolone Pulse Therapy?” JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 67.3 (1999): 398–402. Print.
@article{3100864,
  abstract     = {Criteria for the non-invasive diagnosis of lymphocytic hypophysitis (LyHy) and the results of the first prospective trial of high dose methylprednisolone pulse therapy (HDMPT) in nine patients are presented. In three patients, the diagnosis was established histologically, and in the others by clinical and endocrinological assessment, MRI, CSF examination, and measurement of thyroglobulin autoantibody concentration. After HDMPT, adenopituitary function improved in four of the nine patients and diabetes insipidus ceased or improved in all four concerned patients. The MRI findings improved in seven patients. LyHy has to be considered in the differential diagnosis of sellar lesions. The presumptive non-invasive diagnosis of LyHy seems possible in a high proportion of patients. HDMPT may result in the improvement of clinical, endocrinological, and MRI findings.},
  author       = {Kristof, Rudolf A and Van Roost, Dirk and Klingmüller, Dietrich and Springer, Wolfram and Schramm, Johannes},
  issn         = {0022-3050},
  journal      = {JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY},
  keywords     = {pulse therapy,HYPOPITUITARISM,high dose methylprednisolone,lymphocytic hypophysitis,INVOLVEMENT,PITUITARY,CAVERNOUS SINUS},
  language     = {eng},
  number       = {3},
  pages        = {398--402},
  title        = {Lymphocytic hypophysitis: non-invasive diagnosis and treatment by high dose methylprednisolone pulse therapy?},
  url          = {http://dx.doi.org/10.1136/jnnp.67.3.398},
  volume       = {67},
  year         = {1999},
}

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