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Recombinant human thyrotropin in thyroid cancer and hypopituitarism due to sella metastasis

(1999) THYROID. 9(12). p.1253-1256
Author
Organization
Abstract
We present a patient with thyroid cancer and hypopituitarism who required recombinant human thyrotropin (rhTSH) for I-131 Scanning with respect to subsequent therapy. The thyroid cancer had been unknown until central neurological symptoms developed, leading to the diagnosis of a huge metastasis to the sella that was the only manifestation of metastatic spread. The failure to generate endogenous thyrotropin (TSH) was overcome by the use of rhTSH for performing a I-131 test. Unfortunately, the I-131 uptake was not sufficient for therapy. This subject is the first reported case who required the application of rhTSH due to a single thyroid cancer metastasis in the sella region with secondary failure to generate endogenous TSH.
Keywords
I-131, PITUITARY, WITHDRAWAL, HORMONE, CARCINOMA

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Citation

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Chicago
Risse, Jörn H, Frank Grünwald, Hans Bender, Heinrich Schüller, Dirk Van Roost, and Hans-Jürgen Biersack. 1999. “Recombinant Human Thyrotropin in Thyroid Cancer and Hypopituitarism Due to Sella Metastasis.” Thyroid 9 (12): 1253–1256.
APA
Risse, J. H., Grünwald, F., Bender, H., Schüller, H., Van Roost, D., & Biersack, H.-J. (1999). Recombinant human thyrotropin in thyroid cancer and hypopituitarism due to sella metastasis. THYROID, 9(12), 1253–1256.
Vancouver
1.
Risse JH, Grünwald F, Bender H, Schüller H, Van Roost D, Biersack H-J. Recombinant human thyrotropin in thyroid cancer and hypopituitarism due to sella metastasis. THYROID. 1999;9(12):1253–6.
MLA
Risse, Jörn H et al. “Recombinant Human Thyrotropin in Thyroid Cancer and Hypopituitarism Due to Sella Metastasis.” THYROID 9.12 (1999): 1253–1256. Print.
@article{3100823,
  abstract     = {We present a patient with thyroid cancer and hypopituitarism who required recombinant human thyrotropin (rhTSH) for I-131 Scanning with respect to subsequent therapy. The thyroid cancer had been unknown until central neurological symptoms developed, leading to the diagnosis of a huge metastasis to the sella that was the only manifestation of metastatic spread. The failure to generate endogenous thyrotropin (TSH) was overcome by the use of rhTSH for performing a I-131 test. Unfortunately, the I-131 uptake was not sufficient for therapy. This subject is the first reported case who required the application of rhTSH due to a single thyroid cancer metastasis in the sella region with secondary failure to generate endogenous TSH.},
  author       = {Risse, J{\"o}rn H and Gr{\"u}nwald, Frank and Bender, Hans and Sch{\"u}ller, Heinrich and Van Roost, Dirk and Biersack, Hans-J{\"u}rgen},
  issn         = {1050-7256},
  journal      = {THYROID},
  language     = {eng},
  number       = {12},
  pages        = {1253--1256},
  title        = {Recombinant human thyrotropin in thyroid cancer and hypopituitarism due to sella metastasis},
  url          = {http://dx.doi.org/10.1089/thy.1999.9.1253},
  volume       = {9},
  year         = {1999},
}

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