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In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus

(2011) PLOS ONE. 6(5).
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Abstract
The acquisition of mitochondria was a key event in eukaryote evolution. The aim of this study was to identify homologues of the components of the mitochondrial protein import machinery in the brown alga Ectocarpus and to use this information to investigate the evolutionary history of this fundamental cellular process. Detailed searches were carried out both for components of the protein import system and for related peptidases. Comparative and phylogenetic analyses were used to investigate the evolution of mitochondrial proteins during eukaryote diversification. Key observations include phylogenetic evidence for very ancient origins for many protein import components (Tim21, Tim50, for example) and indications of differences between the outer membrane receptors that recognize the mitochondrial targeting signals, suggesting replacement, rearrangement and/or emergence of new components across the major eukaryotic lineages. Overall, the mitochondrial protein import components analysed in this study confirmed a high level of conservation during evolution, indicating that most are derived from very ancient, ancestral proteins. Several of the protein import components identified in Ectocarpus, such as Tim21, Tim50 and metaxin, have also been found in other stramenopiles and this study suggests an early origin during the evolution of the eukaryotes.
Keywords
PROCESSING PEPTIDASE, YEAST MITOCHONDRIA, DISULFIDE BOND FORMATION, OUTER-MEMBRANE BIOGENESIS, AMINO-ACID-SEQUENCE, INNER-MEMBRANE, SACCHAROMYCES-CEREVISIAE, INTERMEMBRANE SPACE, SUBCELLULAR-LOCALIZATION, PRECURSOR PROTEINS

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Chicago
Delage, Ludovic, Catherine Leblanc, Pi Nyvall Collén, Bernhard Gschloessl, Marie-Pierre Oudot, Lieven Sterck, Julie Poulain, Jean-Marc Aury, and Mark J Cock. 2011. “In Silico Survey of the Mitochondrial Protein Uptake and Maturation Systems in the Brown Alga Ectocarpus Siliculosus.” Plos One 6 (5).
APA
Delage, L., Leblanc, C., Collén, P. N., Gschloessl, B., Oudot, M.-P., Sterck, L., Poulain, J., et al. (2011). In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus. PLOS ONE, 6(5).
Vancouver
1.
Delage L, Leblanc C, Collén PN, Gschloessl B, Oudot M-P, Sterck L, et al. In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus. PLOS ONE. 2011;6(5).
MLA
Delage, Ludovic, Catherine Leblanc, Pi Nyvall Collén, et al. “In Silico Survey of the Mitochondrial Protein Uptake and Maturation Systems in the Brown Alga Ectocarpus Siliculosus.” PLOS ONE 6.5 (2011): n. pag. Print.
@article{3098913,
  abstract     = {The acquisition of mitochondria was a key event in eukaryote evolution. The aim of this study was to identify homologues of the components of the mitochondrial protein import machinery in the brown alga Ectocarpus and to use this information to investigate the evolutionary history of this fundamental cellular process. Detailed searches were carried out both for components of the protein import system and for related peptidases. Comparative and phylogenetic analyses were used to investigate the evolution of mitochondrial proteins during eukaryote diversification. Key observations include phylogenetic evidence for very ancient origins for many protein import components (Tim21, Tim50, for example) and indications of differences between the outer membrane receptors that recognize the mitochondrial targeting signals, suggesting replacement, rearrangement and/or emergence of new components across the major eukaryotic lineages. Overall, the mitochondrial protein import components analysed in this study confirmed a high level of conservation during evolution, indicating that most are derived from very ancient, ancestral proteins. Several of the protein import components identified in Ectocarpus, such as Tim21, Tim50 and metaxin, have also been found in other stramenopiles and this study suggests an early origin during the evolution of the eukaryotes.},
  articleno    = {e19540},
  author       = {Delage, Ludovic and Leblanc, Catherine and Coll{\'e}n, Pi Nyvall and Gschloessl, Bernhard and Oudot, Marie-Pierre and Sterck, Lieven and Poulain, Julie and Aury, Jean-Marc and Cock, Mark J},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  language     = {eng},
  number       = {5},
  pages        = {18},
  title        = {In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus},
  url          = {http://dx.doi.org/10.1371/journal.pone.0019540},
  volume       = {6},
  year         = {2011},
}

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