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N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis

Rob De Vreese (UGent) and Matthias D'hooghe (UGent)
Author
Organization
Abstract
The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Bronsted acids with NHCs has added a new dimension to the field of cooperative catalysis, enabling the stereoselective synthesis of functionalized pyrrolidin-2-ones as valuable scaffolds in heterocyclic chemistry. This Commentary will briefly highlight the concept of N-heterocyclic carbene/Bronsted acid cooperative catalysis as a new and powerful methodology in organic chemistry.
Keywords
CYCLIZATION, ALDEHYDES, BUTYROLACTONES, ORGANOCATALYSIS, CARBENE, STETTER REACTION, DIRECT ANNULATIONS, STEREOSELECTIVE-SYNTHESIS, SUBSTITUTED GAMMA-LACTAMS, stereoselectivity, N-heterocyclic carbenes, gamma-lactams, cooperative catalysis, Bronsted acids, UMPOLUNG

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Citation

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MLA
De Vreese, Rob, and Matthias D’hooghe. “N-Heterocyclic carbene/Brønsted Acid Cooperative Catalysis as a Powerful Tool in Organic Synthesis.” BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 8 (2012): 398–402. Print.
APA
De Vreese, R., & D’hooghe, M. (2012). N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 8, 398–402.
Chicago author-date
De Vreese, Rob, and Matthias D’hooghe. 2012. “N-Heterocyclic carbene/Brønsted Acid Cooperative Catalysis as a Powerful Tool in Organic Synthesis.” Beilstein Journal of Organic Chemistry 8: 398–402.
Chicago author-date (all authors)
De Vreese, Rob, and Matthias D’hooghe. 2012. “N-Heterocyclic carbene/Brønsted Acid Cooperative Catalysis as a Powerful Tool in Organic Synthesis.” Beilstein Journal of Organic Chemistry 8: 398–402.
Vancouver
1.
De Vreese R, D’hooghe M. N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY. 2012;8:398–402.
IEEE
[1]
R. De Vreese and M. D’hooghe, “N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis,” BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 8, pp. 398–402, 2012.
@article{3097479,
  abstract     = {The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Bronsted acids with NHCs has added a new dimension to the field of cooperative catalysis, enabling the stereoselective synthesis of functionalized pyrrolidin-2-ones as valuable scaffolds in heterocyclic chemistry. This Commentary will briefly highlight the concept of N-heterocyclic carbene/Bronsted acid cooperative catalysis as a new and powerful methodology in organic chemistry.},
  author       = {De Vreese, Rob and D'hooghe, Matthias},
  issn         = {1860-5397},
  journal      = {BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY},
  keywords     = {CYCLIZATION,ALDEHYDES,BUTYROLACTONES,ORGANOCATALYSIS,CARBENE,STETTER REACTION,DIRECT ANNULATIONS,STEREOSELECTIVE-SYNTHESIS,SUBSTITUTED GAMMA-LACTAMS,stereoselectivity,N-heterocyclic carbenes,gamma-lactams,cooperative catalysis,Bronsted acids,UMPOLUNG},
  language     = {eng},
  pages        = {398--402},
  title        = {N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis},
  url          = {http://dx.doi.org/10.3762/bjoc.8.43},
  volume       = {8},
  year         = {2012},
}

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