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Normal and pathologic concentrations of uremic toxins

Flore Duranton, Gerald Cohen, RITA DE SMET, Mariano Rodriguez, Joachim Jankowski, Raymond Vanholder UGent and Angel Argiles (2012) JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 23(7). p.1258-1270
abstract
An updated review of the existing knowledge regarding uremic toxins facilitates the design of experimental studies. We performed a literature search and found 621 articles about uremic toxicity published after a 2003 review of this topic. Eighty-seven records provided serum or blood measurements of one or more solutes in patients with CKD. These records described 32 previously known uremic toxins and 56 newly reported solutes. The articles most frequently reported concentrations of beta 2-microglobulin, indoxyl sulfate, homocysteine, uric acid, and parathyroid hormone. We found most solutes (59%) in only one report. Compared with previous results, more recent articles reported higher uremic concentrations of many solutes, including carboxymethyllysine, cystatin C, and parathyroid hormone. However, five solutes had uremic concentrations less than 10% of the originally reported values. Furthermore, the uremic concentrations of four solutes did not exceed their respective normal concentrations, although they had been previously described as uremic retention solutes. In summary, this review extends the classification of uremic retention solutes and their normal and uremic concentrations, and it should aid the design of experiments to study the biologic effects of these solutes in CKD.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
BETA-TRACE PROTEIN, HEMODIALYSIS-PATIENTS, ENDOTHELIAL GROWTH-FACTOR, MOLECULAR-WEIGHT PROTEINS, ASYMMETRIC DIMETHYLARGININE ADMA, CHRONIC-RENAL-FAILURE, CHRONIC KIDNEY-DISEASE, P-CRESOL, GUANIDINO COMPOUNDS, INDOXYL SULFATE
journal title
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
J. Am. Soc. Nephrol.
volume
23
issue
7
pages
1258 - 1270
Web of Science type
Article
Web of Science id
000306026800019
JCR category
UROLOGY & NEPHROLOGY
JCR impact factor
8.987 (2012)
JCR rank
2/73 (2012)
JCR quartile
1 (2012)
ISSN
1046-6673
DOI
10.1681/ASN.2011121175
language
English
UGent publication?
yes
classification
A1
additional info
correction was published in J. Am. Soc. Nephrol. (2013) 24(12), 2127-2129; DOI 10.1681/ASN.2013090956
copyright statement
I have transferred the copyright for this publication to the publisher
id
3096956
handle
http://hdl.handle.net/1854/LU-3096956
date created
2013-01-17 16:14:32
date last changed
2016-12-19 15:39:04
@article{3096956,
  abstract     = {An updated review of the existing knowledge regarding uremic toxins facilitates the design of experimental studies. We performed a literature search and found 621 articles about uremic toxicity published after a 2003 review of this topic. Eighty-seven records provided serum or blood measurements of one or more solutes in patients with CKD. These records described 32 previously known uremic toxins and 56 newly reported solutes. The articles most frequently reported concentrations of beta 2-microglobulin, indoxyl sulfate, homocysteine, uric acid, and parathyroid hormone. We found most solutes (59\%) in only one report. Compared with previous results, more recent articles reported higher uremic concentrations of many solutes, including carboxymethyllysine, cystatin C, and parathyroid hormone. However, five solutes had uremic concentrations less than 10\% of the originally reported values. Furthermore, the uremic concentrations of four solutes did not exceed their respective normal concentrations, although they had been previously described as uremic retention solutes. In summary, this review extends the classification of uremic retention solutes and their normal and uremic concentrations, and it should aid the design of experiments to study the biologic effects of these solutes in CKD.},
  author       = {Duranton, Flore and Cohen, Gerald and DE SMET, RITA and Rodriguez, Mariano and Jankowski, Joachim and Vanholder, Raymond and Argiles, Angel},
  issn         = {1046-6673},
  journal      = {JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY},
  keyword      = {BETA-TRACE PROTEIN,HEMODIALYSIS-PATIENTS,ENDOTHELIAL GROWTH-FACTOR,MOLECULAR-WEIGHT PROTEINS,ASYMMETRIC DIMETHYLARGININE ADMA,CHRONIC-RENAL-FAILURE,CHRONIC KIDNEY-DISEASE,P-CRESOL,GUANIDINO COMPOUNDS,INDOXYL SULFATE},
  language     = {eng},
  number       = {7},
  pages        = {1258--1270},
  title        = {Normal and pathologic concentrations of uremic toxins},
  url          = {http://dx.doi.org/10.1681/ASN.2011121175},
  volume       = {23},
  year         = {2012},
}

Chicago
Duranton, Flore, Gerald Cohen, RITA DE SMET, Mariano Rodriguez, Joachim Jankowski, Raymond Vanholder, and Angel Argiles. 2012. “Normal and Pathologic Concentrations of Uremic Toxins.” Journal of the American Society of Nephrology 23 (7): 1258–1270.
APA
Duranton, F., Cohen, G., DE SMET, R., Rodriguez, M., Jankowski, J., Vanholder, R., & Argiles, A. (2012). Normal and pathologic concentrations of uremic toxins. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 23(7), 1258–1270.
Vancouver
1.
Duranton F, Cohen G, DE SMET R, Rodriguez M, Jankowski J, Vanholder R, et al. Normal and pathologic concentrations of uremic toxins. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2012;23(7):1258–70.
MLA
Duranton, Flore, Gerald Cohen, RITA DE SMET, et al. “Normal and Pathologic Concentrations of Uremic Toxins.” JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 23.7 (2012): 1258–1270. Print.