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Intervertebral disk width in dogs with and without clinical signs of disk associated cervical spondylomyelopathy

Steven De Decker, Ingrid Gielen UGent, Luc Duchateau UGent, Holger A Volk and Luc Van Ham UGent (2012) BMC VETERINARY RESEARCH. 8.
abstract
Background: Disk-associated cervical spondylomyelopathy (DA-CSM) is a multifactorial neurological disorder in which progressive caudal cervical spinal cord compression is mainly caused by one or more intervertebral disk protrusions. The Doberman pinscher breed seems predisposed for this condition. The underlying cause and pathophysiology of DA-CSM are currently unknown. Recently, wider intervertebral disks have been put forward as a risk factor for development of clinically relevant DA-CSM. However, little is known about other factors affecting intervertebral disk width. Therefore the aim of this study was to assess the association between intervertebral disk width, measured on magnetic resonance imaging (MRI), and clinical status, age, gender and intervertebral disk location in dogs with and without clinical signs of DA-CSM. Methods: Doberman pinschers with clinical signs of DA-CSM (N=17), clinically normal Doberman pinschers (N=20), and clinically normal English Foxhounds (N=17), underwent MRI of the cervical vertebral column. On sagittal T2-weighted images, intervertebral disk width was measured from C2-C3 to C6-C7. Intra -and interobserver agreement were assessed on a subset of 20 of the 54 imaging studies. Results: Intervertebral disk width was not significantly different between Doberman pinschers with clinical signs of DA-CSM, clinically normal Doberman pinschers or clinically normal English Foxhounds (p=0.43). Intervertebral disk width was positively associated with increasing age (p=0.029). Each monthly increase in age resulted in an increase of disk width by 0.0057mm. Intervertebral disk width was not significantly affected by gender (p=0.056), but was significantly influenced by intervertebral disk location (p <0.0001). The assessed measurements were associated with a good intra -and interobserver agreement. Conclusions: The present study does not provide evidence that wider intervertebral disks are associated with clinical status in dogs with and without DA-CSM. Instead, it seems that cervical intervertebral disk width in dogs is positively associated with increase in age.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
INTRAOBSERVER, INTEROBSERVER, DEGENERATION, AGE, SPINE, BODY RATIOS, DOBERMAN-PINSCHERS, WOBBLER-SYNDROME, Intervertebral disk, Morphometry, Magnetic resonance imaging, Cervical spondylomyelopathy, Wobbler syndrome, FOXHOUNDS, AGREEMENT
journal title
BMC VETERINARY RESEARCH
BMC Vet. Res.
volume
8
article number
126
pages
6 pages
Web of Science type
Article
Web of Science id
000307250800001
JCR category
VETERINARY SCIENCES
JCR impact factor
1.861 (2012)
JCR rank
18/142 (2012)
JCR quartile
1 (2012)
ISSN
1746-6148
DOI
10.1186/1746-6148-8-126
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
3091167
handle
http://hdl.handle.net/1854/LU-3091167
date created
2013-01-11 16:14:04
date last changed
2016-12-21 15:42:06
@article{3091167,
  abstract     = {Background: Disk-associated cervical spondylomyelopathy (DA-CSM) is a multifactorial neurological disorder in which progressive caudal cervical spinal cord compression is mainly caused by one or more intervertebral disk protrusions. The Doberman pinscher breed seems predisposed for this condition. The underlying cause and pathophysiology of DA-CSM are currently unknown. Recently, wider intervertebral disks have been put forward as a risk factor for development of clinically relevant DA-CSM. However, little is known about other factors affecting intervertebral disk width. Therefore the aim of this study was to assess the association between intervertebral disk width, measured on magnetic resonance imaging (MRI), and clinical status, age, gender and intervertebral disk location in dogs with and without clinical signs of DA-CSM. 
Methods: Doberman pinschers with clinical signs of DA-CSM (N=17), clinically normal Doberman pinschers (N=20), and clinically normal English Foxhounds (N=17), underwent MRI of the cervical vertebral column. 
On sagittal T2-weighted images, intervertebral disk width was measured from C2-C3 to C6-C7. Intra -and interobserver agreement were assessed on a subset of 20 of the 54 imaging studies. 
Results: Intervertebral disk width was not significantly different between Doberman pinschers with clinical signs of DA-CSM, clinically normal Doberman pinschers or clinically normal English Foxhounds (p=0.43). Intervertebral disk width was positively associated with increasing age (p=0.029). Each monthly increase in age resulted in an increase of disk width by 0.0057mm. Intervertebral disk width was not significantly affected by gender (p=0.056), but was significantly influenced by intervertebral disk location (p {\textlangle}0.0001). The assessed measurements were associated with a good intra -and interobserver agreement. 
Conclusions: The present study does not provide evidence that wider intervertebral disks are associated with clinical status in dogs with and without DA-CSM. Instead, it seems that cervical intervertebral disk width in dogs is positively associated with increase in age.},
  articleno    = {126},
  author       = {De Decker, Steven and Gielen, Ingrid and Duchateau, Luc and Volk, Holger A and Van Ham, Luc},
  issn         = {1746-6148},
  journal      = {BMC VETERINARY RESEARCH},
  keyword      = {INTRAOBSERVER,INTEROBSERVER,DEGENERATION,AGE,SPINE,BODY RATIOS,DOBERMAN-PINSCHERS,WOBBLER-SYNDROME,Intervertebral disk,Morphometry,Magnetic resonance imaging,Cervical spondylomyelopathy,Wobbler syndrome,FOXHOUNDS,AGREEMENT},
  language     = {eng},
  pages        = {6},
  title        = {Intervertebral disk width in dogs with and without clinical signs of disk associated cervical spondylomyelopathy},
  url          = {http://dx.doi.org/10.1186/1746-6148-8-126},
  volume       = {8},
  year         = {2012},
}

Chicago
De Decker, Steven, Ingrid Gielen, Luc Duchateau, Holger A Volk, and Luc Van Ham. 2012. “Intervertebral Disk Width in Dogs with and Without Clinical Signs of Disk Associated Cervical Spondylomyelopathy.” Bmc Veterinary Research 8.
APA
De Decker, Steven, Gielen, I., Duchateau, L., Volk, H. A., & Van Ham, L. (2012). Intervertebral disk width in dogs with and without clinical signs of disk associated cervical spondylomyelopathy. BMC VETERINARY RESEARCH, 8.
Vancouver
1.
De Decker S, Gielen I, Duchateau L, Volk HA, Van Ham L. Intervertebral disk width in dogs with and without clinical signs of disk associated cervical spondylomyelopathy. BMC VETERINARY RESEARCH. 2012;8.
MLA
De Decker, Steven, Ingrid Gielen, Luc Duchateau, et al. “Intervertebral Disk Width in Dogs with and Without Clinical Signs of Disk Associated Cervical Spondylomyelopathy.” BMC VETERINARY RESEARCH 8 (2012): n. pag. Print.